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South African Journal of Chemistry

versión On-line ISSN 1996-840X


NAIDU, K. Reddimohan et al. A facile catalyst-free Pudovik reaction for the synthesis of α-amino phosphonates. S.Afr.j.chem. (Online) [online]. 2009, vol.62, pp. 185-188. ISSN 1996-840X.

Some imines were synthesized by the reaction of 5-amino 1-naphthol with substituted aromatic aldehydes in ethanol under reflux conditions. Dialkyl phosphites underwent addition with aromatic imines to give novel α-amino phosphonates. All the title compounds were characterized by elemental analysis, IR, 1H, 13C, 31P NMR and mass spectral data. All the newly-synthesized compounds (4a-j) exhibited moderate antibacterial and antifungal activity.

Palabras clave : 5-Amino-1-naphthol; imines; dialkyl phosphite; α-amino phosphonates; antimicrobial activity.

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