Resumo

BROWNE, B; KHUMALO, A  e  TOOKE, L. Similar mortality rates for early and late group B streptococcal disease among newborns at Groote Schuur Hospital in Cape Town. S. Afr. j. child health [online]. 2024, vol.18, n.3, pp.128-132. ISSN 1999-7671.  https://doi.org/10.7196/sajch.2024.v18i3.1767.

BACKGROUND: Invasive group B streptococcal disease (iGBS) is an important cause of morbidity and mortality in newborns globally and is more common in Sub-Saharan Africa and South Africa. Few studies describe newborn iGBS cases in the Western Cape, leaving limited data to guide local prevention and treatment strategies OBJECTIVE: To describe all cases of newborn iGBS at Groote Schuur Hospital (GSH), Western Cape, between January 2015 and December 2020 METHODS: A retrospective review was conducted of all blood or cerebrospinal fluid-positive cases of newborn iGBS between January 2015 and December 2020 RESULTS: Thirty-five cases of iGBS were included in the study, 51% with early-onset disease (EoD) and 49% with late-onset disease (LoD). The median gestational age at birth was 27 and 31.5 weeks in the LoD and EoD groups, respectively. The median birth weight was 900 g and 1 812 g in the LoD and EoD groups, respectively. Meningitis was more common in the LoD group and pneumonia was more common in the EoD group. The overall mortality rate was 23%, with similar mortality rates in the EoD and LoD groups (22% and 24%, respectively). Invasive GBS disease accounted for a cumulative 274 intensive care unit days during the study period CONCLUSION: Invasive GBS disease in newborns at GSH is associated with a high mortality rate, with this study showing similar mortality rates between the EoD and LoD groups

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