Abstract

BHIMMA, R; NAICKER, E  and  MZIMELA, B W. Neonatal HIV-associated nephropathy. S. Afr. j. child health [online]. 2018, vol.12, n.1, pp.38-40. ISSN 1999-7671.  https://doi.org/10.7196/sajch.2018.v12i1.1437.

Human immunodeficiency virus (HIV)-related nephropathy is a significant cause of morbidity and mortality in HIV-1 seropositive children in Africa that presents at any age. To date the youngest patient reported in the literature was from our centre, presenting at 4 months of age. We present here a neonate born to an HIV-1 infected mother on combined anti-retroviral therapy (cART), who had vertical transmission of the virus and presented with congenital nephrotic syndrome at three weeks of life. The child was confirmed to have HIV-1 infection at 6 weeks. Kidney biopsy showed features consistent with HIV-associated nephropathy. On commencement of cART and angiotensin converting enzyme antagonist treatment, there was a substantial decrease in proteinuria. To the best of our knowledge, this is the first report of HIV-associated nephropathy presenting as congenital nephrotic syndrome.

        · text in English     · English ( pdf )