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South African Dental Journal
On-line version ISSN 0375-1562Print version ISSN 0011-8516
Abstract
PEER, F; CHOONARA, YE and KUMAR, P. A Review of Chemical Approaches Inherent to Endodontic Disinfection Protocols: Part 1. S. Afr. dent. j. [online]. 2025, vol.80, n.7, pp.352-362. ISSN 0375-1562. https://doi.org/10.17159/sadj.v80i07.21987.
OBJECTIVES: Endodontic treatment is a common dental procedure. This review paper discusses chemical endodontic disinfection protocols, including types of irrigation solutions, solution activation techniques, and intracanal medicaments. This comprehensive review is structured in two parts: Part one will examine the various types of endodontic irrigation solutions, while Part two will focus on adjunctive strategies to optimise irrigation efficacy, review the use of intracanal medicaments, and provide perspectives on future directions in endodontic therapy MATERIALS AND METHODS: Scientific platforms such as Pubmed and Google Scholar were (re)searched using the keywords: endodontics, endodontic disinfection, root canal disinfection, endodontic chemical debridement, endodontic irrigation, endodontic solutions, endodontic irrigant activation, and intracanal medicaments. Relevant articles were identified, screened, reviewed, and discussed RESULTS: Sodium hypochlorite irrigation supplemented with EDTA remains the most popular, effective and economical protocol for endodontic disinfection CONCLUSIONS: Despite advancements in the field, no single ideal irrigant is available and sodium hypochlorite in combination with EDTA, is the gold standard for endodontic irrigation. Lately, there has been a shift toward developing biocompatible disinfection protocols. Materials such as ozonated oils, morinda citrifolia juice, photo-activated disinfection, nitric oxide-releasing nano matrix, and nanoparticles have been suggested, but further research on their effectiveness is still required RUNNING TITLE: Chemical Approaches for Endodontic Disinfection Protocols
Keywords : Endodontics; chemical disinfection; endodontic irrigation.












