Resumo

BUNN, BK; GWENGU, P  e  NELWAMONDO, D. Spindle cell carcinoma of the lower lip: A case report and review of the literature. S. Afr. dent. j. [online]. 2024, vol.79, n.5, pp.276-280. ISSN 0375-1562.  https://doi.org/10.17159/sadj.v79i05.18054.

BACKGROUND: To document the lip as an unusual site of clinical presentation of spindle cell carcinoma and to conduct a review of the literature. METHODS: A 66-year-old male patient presented with an ulcerated lesion of the lower lip. Morphological examination and immunohistochemical profiling of the lesion were performed. RESULTS: Histopathological examination showed a high-grade spindle cell neoplasm. Pleomorphic fusiform cells with cytological and nuclear atypia were predominant together with conspicuous perineural infiltration. A small focus of overlying stratified squamous parakeratinising epithelium was identified in a section of the lesion. Co-expression of cytokeratin and mesenchymal markers confirms the epithelial-mesenchymal transition which is inherent to this lesion. CONCLUSION: Spindle cell carcinoma (sarcomatoid carcinoma) is a rare variant of squamous cell carcinoma with an infrequent occurrence on the lower lip. The objective in reporting this case is to raise the clinicopathological awareness of this unconventional variant of squamous cell carcinoma to expedite diagnostic and therapeutic intervention. STATEMENT OF CLINICAL RELEVANCE: The documentation of a rare form of oral squamous cell carcinoma at an unusual site allows for expeditious diagnostic and therapeutic intervention.

Palavras-chave : Spindle cell carcinoma; squamous cell carcinoma; sarcomatoid carcinoma; epithelial-mesenchymal transition.

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