SciELO - Scientific Electronic Library Online

SciELO - Scientific Electronic Library Online

Article References

OWEN, E P et al. Complement component C5 and C6 mutation screening indicated in meningococcal disease in South Africa. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.6, pp.525-527. ISSN 2078-5135.

    1. National Institute for Communicable Diseases (NICD). Communicable Disease Surveillance Bulletin 2006, 2007, 2008, 2009 and 2010. (accessed 11 April 201). [ Links ]

    2. von Gottberg A, du Plessis M, Cohen C, et al Emergence of endemic serogroup W135 meningococcal disease associated with a high mortality rate in South Africa. Clin Infect Dis 2008;46:377-386. [] [ Links ]

    3. Orren A, Potter PC, Cooper R, du Toit E. Deficiency of the sixth component of complement and susceptibility to Neisseria meningitidis infections. Studies in ten families and five isolated cases.Immunology 1987;62:249-253. [ Links ]

    4. Wurzner R, Orren A, Potter P, et al Functionally active complement proteins C6 and C7 detected in C6- and C7-deficient individuals. Clin Exp Immunol 1991;83:430-437. [] [ Links ]

    5. Hobart MJ, Fernie BA, Fijen KAPM, Orren A. The molecular bases of C6 deficiency in the Western Cape, South Africa. Hum Genetics 1998;103:506-512. [] [ Links ]

    6. Nishizaka H, Horiuchi T, Zhu ZB, et al. Molecular bases for inherited human complement component C6 deficiency in two unrelated individuals. J Immunology 1996;156:2309-2315. [ Links ]

    7. Zhu ZB, Totemchokchyakarn K, Atkinson TP, Volanakis JE. Molecular defects leading to human complement component C6 deficiency in an African-American family. Clin Exp Immunol 1998;111:91-96. [] [ Links ]

    8. Orren A, Owen EP, Potter PC, Leisegang F, Morgan BP, Wurzner R. Complement component 5 deficiency (C5D) in South Africa. Molecular Immunology 2011;48:1863. [ Links ]

    9. Figueroa JE, Densen P. Infectious diseases associated with complement deficiencies. Clin Microbiol 1991;4:359-395 [ Links ]

    10. Orren A, Owen EP, Henderson HE, et al Complete deficiency of the sixth complement component (C6Q0), susceptibility to Neisseria meningitidis infections, and analysis of the frequencies of C6Q0 gene defects in South Africans. Clinical and Experimental Immunology 2012;167:459-471.[http://] [ Links ]

    11. Wang X, Fleischer DT, Whitehead WT, et al. Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families. J Immunol 1995;154:5464-5471. [ Links ]

    12. Parham KL, Roberts A, Thomas A, et al. Prevalence of mutations leading to complete C6 deficiency (C6Q0) in the Western Cape, South Africa and detection of novel mutations leading to C6Q0 in an Irish family. Mol Immunol 2007;44:2756-2760. [ Links ]

    13. Wurzner R, Xu H, Franzke A, Schulze M, Peters JH, Gotze O. Blood dendritic cells carry terminal complement complexes on their cell surface as detected by newly developed neoepitope-specific monoclonal antibodies. Immunology 1991;74:132-138. [PMID 1718850] [ Links ]

    14. Lopez-Lera A, Garrido S, de la Cruz RM, Fontan G, Lopez-Trascasa M. Molecular Immunology Molecular characterization of three new mutations causing C5 deficiency in two non-related families. Mol Immunol 2009;46:2340-2347. [ Links ]

    15. Aguilar-Ramireza P, Reis ES, Floridoa MPC, et al. Skipping of exon 30 in C5 gene results in complete human C5 deficiency and demonstrates the importance of C5d and CUB domains for stability. Mol Immunol 2009;46:2116-2123. [] [ Links ]

    16. Statistics South Africa. Census 2001. Pretoria, Statistics South Africa, 2003. (accessed 11 April 2012). [ Links ]

    17. Coulson GB, von Gottberg A, du Plessis M, Smith AM, de Gouvia L, Klugman KP. Meningococcal disease in South Africa, 1999 - 2002. Emerging Infect Diseases 2007;13:273-278. [] [ Links ]

    18. Kedibone MM, du Plessis M, von Gottberg A, et al. Distribution of factor H binding protein beyond serogroup B: Variation among five serogroups of invasive Neisseria meningitidis in South Africa. Vaccine 2011;29:2187-2192. [] [ Links ]