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African Journal of Laboratory Medicine

On-line version ISSN 2225-2010
Print version ISSN 2225-2002

Afr. J. Lab. Med. vol.10 n.1 Addis Ababa  2021

http://dx.doi.org/10.4102/ajlm.v10i1.1471 

SCIENTIFIC LETTER

 

Post-mortem diagnosis of COVID-19

 

 

Rujittika MungmungpuntipantipI; Viroj WiwanitkitII

IPrivate Practice, Bangkok, Thailand
IIDepartment of Community Medicine, DY Patil University, Pune, India

Correspondence

 

 

We would like to share our impression on the report 'Postmortem diagnosis of COVID-19: Antemortem challenges of three cases at the 37 Military Hospital, Accra, Ghana'.1 Attoh et al. concluded that 'The outcome of COVID-19 testing is dependent on the sample type and accuracy of sampling amongst other factors'1 and suggested that 'more autopsies are required to fully understand the pathogenesis of this disease in Ghanaians'.1 Indeed, post-mortem diagnosis of coronavirus disease 2019 (COVID-19) is possible and there are many reports of the existence of pathogenic viruses in autopsy specimens.2,3 Autopsy is also very useful for understanding the pathogenesis of this new disease. However, it must be performed with high caution. While there are no confirmed cases of the pathogen being spread from deceased patients, infection of forensic pathology workers has been reported.4 More autopsies might be recommended, but adequate biosafety and biosecurity, and other infection control precautions must be in place for these to occur.

 

Response from Attoh et al.

In our article we did not go into details on the methodology. Although COVID-19 is a category 3 infectious agent, negative pressure systems are unavailable in our country. Therefore, a few modifications were made.

Post-mortems were performed using World Health Organization's interim guidance for infection prevention and control for the safe management of a dead body in the context of COVID-19.5 The structural design of the autopsy suites used lacked negative pressure systems with filters. As a result, extractors were fitted to provide unidirectional airflow away from the anatomical pathology team into the atmosphere as an appropriate technology. Also, members of the anatomical pathology team were carefully selected to exclude those with chronic health conditions such as diabetes mellitus, and cardiovascular and respiratory diseases.

It is interesting to note that none of the forensic pathologists nor the anatomical pathology technicians involved in the study have shown COVID-19 symptoms up to today.

 

Acknowledgements

Competing interests

The authors have declared that no competing interests exist.

Authors' contributions

R.M. and V.W. have equal contributions in giving ideas, drafting, analysing, writing and giving final approval for this submission.

Ethical considerations

This article followed all ethical standards for research without direct contact with human or animal subjects.

Sources of support

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Data availability statement

Data sharing is not applicable to this article as no new data were created or analysed in this study.

Disclaimer

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of any affiliated agency of the authors.

 

References

1. Attoh SA, Hobenu F, Edusei L, et al. Postmortem diagnosis of COVID-19: Antemortem challenges of three cases at the 37 Military Hospital, Accra, Ghana. Afr J Lab Med. 2020 Nov 3;9(1):a1290. https://doi.org/10.4102/ajlm.v9i1.1290        [ Links ]

2. Sawant OB, Singh S, Wright 3rd, RE, et al. Prevalence of SARS-CoV-2 in human post-mortem ocular tissues. Ocul Surf. 2020;Nov 8;S1542-0124(20)30168-3.         [ Links ]

3. Zijlstra JG, Van Meurs M, Moser J. Post-mortem diagnostics in COVID-19 AKI, more often but timely. J Am Soc Nephrol. 2021;32(1):255. https://doi.org/10.1681/ASN.2020091263        [ Links ]

4. Sriwijitalai W, Wiwanitkit V. COVID-19 in forensic medicine unit personnel: Observation from Thailand. J Forensic Leg Med. 2020 May;72:101964. https://doi.org/10.1016/j.jflm.2020.101964        [ Links ]

5. World Health Organization (WHO). Infection prevention and control for the safe management of a dead body in the context of COVID-19: Interim guidance [homepage on the Internet]. World Health Organization, 2020; p. 6. WHO reference number: WHO/2019-nCoV/IPC_DBMgmt/2020.2. Available from: https://www.who.int/publications/i/item/infection-prevention-and-control-for-the-safe-management-of-a-dead-body-in-the-context-of-covid-19-interim-guidance        [ Links ]

 

 

Correspondence:
Rujittika Mungmungpuntipantip
rujittika@gmail.com

Received: 26 Nov. 2020
Accepted: 23 Dec. 2020
Published: 24 Mar. 2021

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