SciELO - Scientific Electronic Library Online

 
vol.15 número1The experiences of teleradiology end users regarding role extension in a rural district of the North West province: A qualitative analysisModelling cost benefit of community-oriented primary care in rural South Africa índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Em processo de indexaçãoSimilares em Google

Compartilhar


African Journal of Primary Health Care & Family Medicine

versão On-line ISSN 2071-2936
versão impressa ISSN 2071-2928

Afr. j. prim. health care fam. med. (Online) vol.15 no.1 Cape Town  2023

http://dx.doi.org/10.4102/phcfm.v15i1.3777 

REVIEW ARTICLE

 

Facilitators and barriers to in vitro diagnostics implementation in resource-limited settings: A scoping review

 

 

Monica Ansu-MensahI, II; Desmond KuupielI, III; Emmanuel A. AsiamahI, IV, V; Themba G. GinindzaI, IV

IDepartment of Public Health Medicine, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
IIThe University Clinic, Sunyani Technical University, Sunyani, Ghana
IIIFaculty of Health Sciences, Durban University of Technology, Durban, South Africa
IVCentre for Infectious Diseases Epidemiology Research Unit (CIDERU), College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
VDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana

Correspondence

 

 


ABSTRACT

BACKGROUND: The World Health Organization (WHO) developed the model list of essential in vitro diagnostics (EDL) to guide countries to develop and update point-of-care (POC) per their disease priorities. The EDL includes POC diagnostic tests for use in health facilities without laboratories; however, their implementation might face several challenges in low- and middle-income countries (LMICs
AIM: To identify facilitators and barriers to POC testing service implementations in the primary health care facilities in the LMICs
SETTING: Low- and middle-income countries
METHODS: This scoping review was guided by Arksey and O'Malley's methodological framework. A comprehensive keyword search for literature was conducted in Google Scholar, EBSCOhost, PubMed, Web of Science and ScienceDirect using the Boolean terms ('AND' and 'OR'), as well as Medical Subject Headings. The study considered published articles in the English language from 2016 to 2021 and was limited to qualitative, quantitative and mixed-method studies. Two reviewers independently screened the articles at the abstract and full-text screening phases guided by the eligibility criteria. Data were analysed qualitatively and quantitatively
RESULTS: Of the 57 studies identified through literature searches, 16 met this study's eligibility criteria. Of the 16 studies, 7 reported on both facilitators and barriers; and the remainder reported on only barriers to POC test implementation such as inadequate funding, insufficient human resource, stigmatisation, et cetera
CONCLUSION: The study demonstrated a wide research gap in facilitators and barriers, especially in the general POC diagnostic test for use in health facilities without laboratories in the LMICs. Extensive research in POC testing service is recommended to improve service delivery
CONTRIBUTION: This study's findings contribute to a few works of literature on existing evidence of POC testing

Keywords: facilitators; barriers; essential in vitro diagnostics; primary healthcare facilities; LMICs.


 

 

Introduction

The battle against communicable and noncommunicable diseases (NCDs) has recently become the highest priority in the low- and middle-income countries (LMICs), especially in the World Health Organization (WHO) Africa Region.1,2,3,4,5 The majority of the top 10 causes of death occurring in sub-Saharan Africa (SSA) are from communicable diseases.3 Mention could be made of malaria, human immunodeficiency virus (HIV) and tuberculosis (TB) death.4 The WHO global malaria report for the year 2020 showed 241 million cases and 62 700 deaths, out of which 95% of the cases and 96% of deaths occurred in the WHO Africa Region. Again, about 10m cases and 1.5m deaths are recorded every year for TB with the larger proportion occurring in the LMICs.6 Sub-Saharan Africa has over the past decade experienced a surge in diabetes and hypertension among these countries with 80% premature deaths from NCDs.1 In an attempt to combat the disease burdens, the Sustainable Development Goals (SDGs) seek to ensure healthy lives and promote well-being at all ages by 2030.7 This partly necessitated the introduction of the WHO model list of essential in vitro diagnostics (EDL), as the basis for strengthening diagnostic testing capacity and increasing access to in vitro diagnostics (IVDs). The EDL offers guidance to countries on methods to develop, update and prioritise the IVDs.8 The WHO's EDL provides a range of tests for general and disease-specific IVDs mostly in point-of-care (POC) form for use in healthcare facilities with or without laboratories.8 Tier 1 facilities refer to primary care settings with healthcare professionals but no trained laboratory personnel, self-testing or low resource settings.8,9,10,11,12 Point-of-care diagnostics refer to advanced technological-based medical devices for testing, screening and monitoring diseases in services near patients or clients.13,14 Point-of-care diagnostics have shown to be a useful tool for improving disease diagnosis and treatment globally.15,16 Evidence showed POC testing has improved antenatal HIV screening in sub-Sahara Africa.3 In resource-limited settings, POC technologies have become reliable and very important by providing healthcare providers with the easiest, most convenient and most accurate way of decision-making on diagnosis and treatment.3,14,17,18,19,20,21,22,23 The quality of POC for limited-resource settings according to the WHO should be designed to meet the following benchmarks: affordable, sensitive, specific, user-friendly, rapid or robust, equipment-free, and delivered to those who need it (ASSURED).8,24,25,26,27

Despite the benefits derived from POC testing, there are challenges with its implementation, which hinder accessibility for many patients in the LMICs.28,29 Implementation and sustainability of POC testing in resource-limited settings are feasible when potential barriers are addressed.30 Barriers to POC testing implementation may include challenges making POC testing service implementation difficult. Examples of these include low availability, low stock levels, procurement issues, poor supply chain management, funding, human resource capacity and many others.21,24,27,31,32,33 Facilitators of POC testing are motivators or factors which contribute to POC testing implementation. For instance, effective regulations on quality and training enable the successful implementation of POC testing in healthcare facilities.34

A wide research gap in the general POC test for use in a health facility without laboratories suggests presumptive treatment and poor health outcomes in many LMICs. Therefore, the need to investigate the barriers and facilitators of POC test implementation of general POC diagnostic testing services is of utmost importance.

 

Methods

We adopted Arksey and O'Malley's framework as a guide to conduct this scoping review. The preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews checklist were used to report this study.35

Identifying the research question

The research question for this study was: To date, what evidence exists on facilitators and barriers to implementation of the WHO EDL for use in tier one healthcare facilities in LMICs? Table 1 shows the framework (population, content and context [PCC]) used to determine the suitability of the review question.

 

 

Literature search

With a date limitation of 2016-2021, we searched five electronic databases (Google Scholar, Academic Search Complete via EBSCOhost, PubMed, Web of Science and ScienceDirect) for relevant studies (Appendix 1). We used a combination of the following keywords: 'facilitator', OR 'enablers' AND 'barriers' AND 'point-of-care testing services', AND 'point-of-care diagnostics services', AND 'in vitro diagnostics', AND 'implementation', AND 'lower-and-middle income countries' OR 'LMICs'. Medical subject headings were applied in the search strategy. Limitations on language and study design were removed.

Eligibility criteria

Articles published only in the English language were included subject to the eligibility criteria. Such articles also had to be written in at least one of the LMICs on facilitators and barriers and focus on either POC testing services or in vitro diagnostics in primary health care (PHC) facilities. This review was limited to primary study designs (qualitative, quantitative and mixed-methods study). We excluded all articles published before the year 2016.

Study selection

The databases' search and the title screening were conducted using the eligibility criteria. A clean library was shared with the review team after all duplicates were removed. Two authors independently screened abstracts and full articles using tools pilot-tested by the review team. The review team discussed all discrepancies that arose at the abstract screening stage between these two authors until a consensus was reached. Then, the last two authors addressed the discrepancies during the full-text screening phase.

Charting the data

We extracted the following: author and publication year, the country where the study was conducted, study design, study setting, study population, type of POC test, type of barrier of POC diagnostics testing, facilitators to POC testing implementation, type of general IVDs test, and type of disease-specific diagnostic test. We also extracted the findings relevant to answering the review question using a deductive approach. To ensure the credibility and accuracy of the study finds, Monica Ansu-Mensah and Desmond Kuupiel independently abstracted the data with TGG: Themba G. Ginindza acting as the arbitrator.

Collating and summarising the results

Thematic analysis was conducted following the data extraction. The data were collated into themes and a summary of the study outcomes was reported in a narrative form.

Ethical considerations

This article followed all ethical standards for research without direct contact with human or animal subjects.

 

Results

Of the 72 eligible articles obtained from the databases search, 16 duplicates were removed. Out of the remaining 57 articles screened, 32 were excluded at the abstract screening stage. A further 25 articles were removed during the full-text screening phase. Finally, 16 articles remained for data extraction and analysis. The reasons for exclusion following the full-text screening were the following: five were review papers24,38,39,40,41; two were conducted in high-income countries42,43; one article focused on a POC test not included in the WHO EDL44; and one reported on a POC test for health facilities with laboratories45 (Figure 1).

 

 

Characteristics of the included studies

Out of the 16 included articles for this study, five (31%) reported from South Africa,46,47,48,49,50 three (19%)4,27,51,52,53,54 reported from Kenya and Ghana respectively, one (6%) each was conducted in Papua New Guinea (PNG),55 Burkina Faso,4 Malawi,56 there were two multi-country studies (Zambia and Malawi),57 and (Brazil, Bulgaria, China, Macedonia, Malaysia, Peru, Serbia, South Africa, Turkey, Burma, Egypt, Georgia, India, Indonesia, Kenya, Nigeria, Pakistan, PNG, Vietnam, Cambodia, Mali, Uganda and Zimbabwe).58 Of the 16 included articles, 63% (n = 10) were qualitative studies4,47,48,51,52,53,56,57,58,59; 25% (n = 4) were cross-sectional surveys27,46,48,54; and approximately 6% (n = 1) each was a mixed-method55 and an experimental study49 (Table 2).

 

Study findings

Of the 16 included studies, 7 studies reported on both facilitators and barriers to POC testing implementation.47,51,52,55,56,59 The remaining 9 reported on different challenges with POC testing implementation (Table 3).4,27,46,48,53,54,57,58

Point-of-care test for use in health facilities without laboratories

Of the 16 included studies, only two studies reported on five types of general POC tests: blood typing, haemoglobin, urinalysis, glucose and urine pregnancy test among the numerous general IVDs for use in health facilities without laboratories.27,54 Six types of disease-specific IVDs were documented by 10 studies,27,46,47,50,51,52,53,56,57,59 and one study did not specify the type of IVD47 See (Figure 2).

 

 

Barriers to point-of-care test implementation

Although some barriers were country-specific, other countries in the included studies reported similar barriers. Human resource issues, such as the increased workload of healthcare professionals46,48,51,52,58 and inadequate human resources,54,56 were reported as major barriers to POC test implementation by some included studies. Again, the low availability of POC tests or inadequate resources were cited as other barriers to the implementation of POC testing services by some studies.48,51,54,55,57 Chamane et al. study from South Africa, Reipold et al. study on 23 LMICs, and Maddox et al. study from Malawi documented a lack of policy guidelines to regulate POC test implementation.46,56,58 Furthermore, insufficient funding to support staff training and procurement of logistics and supplies were unveiled by both Reipold et al. study from 23 countries in the LMICs and Maddox et al. study from Malawi. It is well noted that participation enhances commitment; a study from South Africa and Kenya reported lack of leadership and staff involvement in POC implementation as a barrier.46,52 Unlike the former, low patient awareness was the challenge with the POC test implementation.49,58 Chamane et al. also documented the absence of a POC testing curriculum as well as the lack of training and continuous professional development for healthcare workers as some of the implementation challenges. Although workflow disruption and increased administrative burden should have been seen as common barriers to POC testing implementation, these were reported by Van Hecke et al.48 and Bocoum et al.,59 respectively, from South Africa. According to a study from Ghana by Palmer et al., poor communication and lack of trust between groups were seen as barriers to POC test implementation.4 Lack of counseling, pain and 'I do not want to know' were the barriers presented by Rao et al. study from South Africa, which hinder the implementation of HIV POC testing services.50 Finally, Macharia et al. reported in Kenya that fear of disclosure, HIV stigma and confidentiality are the main barriers to POC implementation.53

Facilitators to point-of-care test implementation

Among the included studies, Reddy et al., Bocoum et al., Rao et al. and Maddox et al. reported that the high acceptability of the POC test is a major facilitator for its implementation.47,50,56 According to Rao et al. and Wexler et al., POC test implementation is influenced by its rapid result which renders a short waiting time for patients.50,52 Moreover, according to Mohamed et al., proper coordination among stakeholders, adequate supply of consumables and frequent refresher courses for providers enable POC test implementation in the LMICs.55 Similar to Mohamed et al. study, Wexler et al. reported provider expertise and enthusiasm as enablers of POC test implementation.51 Of all the studies, peculiar reports such as easy assessment of disease progression47 and patient motivation51 were part of the facilitators of POC test implementation by Reddy et al. and Wexler respectfully. Furthermore, Bocoum et al. from Burkina Faso documented the political environment and easy use of the POC test as facilitators for its implementation.59

 

Discussion

This study was carried out to describe existing literature on barriers and facilitators to diagnostic POC testing implementation at health facilities without laboratories in LMICs. We found 16 studies from 27 countries reporting on POC diagnostics in LMICs. These 27 countries include Brazil, Bulgaria, Burkina Faso, Burma, Cambodia, China, Egypt, Georgia, Ghana, India, Indonesia, Kenya, Macedonia, Malawi, Malaysia, Mali, Nigeria, Pakistan, Papua New Guinea, Peru, Serbia, South Africa, Turkey, Uganda, Vietnam, Zambia and Zimbabwe. The study result indicated fewer (37%) reports on the facilitators to POC diagnostics46,47,49,50,51,54 than barriers (63%).4,27,45,47,48,52,53,56,57,58 We discovered limited literature reporting on both facilitators and barriers to POC diagnostics test implementation in the LMICs, especially concerning general POC diagnostic tests for using health facilities without laboratories.

Existing literature on POC testing services implementation focused on demand-side barriers and facilitators of POC testing in advanced countries. These studies revealed patients' acceptability and healthcare professional use of POC tests in clinical medicine in PHC facilities.32,36

POC testing is a vital component of the health system concerning accurate diagnosis, monitoring and screening. Though the WHO does not give specifications on the minimal performance for different POC tests, it is recommended that the safety and performance that meet quality standards should be considered by the WHO ASSURED.25,27,33,44 Again, the WHO recommends a country-specific design of IVDs that meet each country's epidemiological burden.9,10 It is, therefore, imperative to investigate through primary research the barriers and facilitators to implementing diagnostic POC testing in resource-limited settings in LMICs. In addition, to achieve the SDG 3.8 (universal health coverage) target, it is very necessary to explore facilitators to POC diagnostic testing in the resource-limited settings in the LMICs since it has a strong bearing on the improvement and strengthening of the healthcare system in diagnosis, monitoring and treatment. Though studies were found in 27 LMICs, evidence was found from only six studies with regards to facilitators, which include coordination, adequate supply of consumables, refresher training programmes, enhanced patients' motivation, provider enthusiasm and expertise, political environment and high acceptability. Notwithstanding, included studies revealed that low availability of POC tests concern about confidentiality, policy guidelines, inadequate funding to support staff training, poor supply chain management, poor communication, lack of staff involvement and leadership participation in POC management programmes, and absence of continuous professional development were major barriers to POC testing services implementation in the rural areas. Again, out of the 18 existing POC diagnostic tests recommended by the WHO for use in health facilities without laboratories, no studies were found on POC tests such as CD4 cell enumeration, ketones, albumin, bilirubin and white blood lactate.

Implication for practice

The study findings imply that all rural areas in the LMICs have various challenges impeding POC testing implementation and its sustainability, which render quality of care below standard. The low availability of POC tests might have contributed to poor accessibility in the resource-limited settings in LMICs. This challenge may also result in referrals and the distraction of workflow. Thus, patients travel from their local communities to bigger facilities for some POC tests not available in their healthcare setting. It also implies more spending because of travel costs and sometimes additional costs on healthcare aside subjecting patients to more risk on the travel route. Moreover, low availability will imply that presumptive treatment, wrongful diagnosis and poor health outcomes will be high. Again, barriers such as the absence of training of staff and lack of staff involvement in POC management programmes may deny healthcare providers the professional skills in counseling and handling confidential information. Conversely, patients' trust in health workers on confidential matters will be jeopardised. Human resource challenges might have resulted from inadequate funding to support the training of staff, which, consequently, might have contributed to a high workload of staff, poor supply chain management and an increase in administrative burden. We, therefore, recommend further studies to evaluate potential solutions to address the barriers to the POC diagnostic test implementation in resource-limited settings towards optimising the well-being of the individual and achieving SDG 3.8 (universal health coverage).

Implication for research

The study shows limited primary research investigating the WHO EDL and POC test services in the LMICs. A sustainable POC test service will enhance accurate diagnosis and the improved well-being of individuals. Therefore, more primary research focusing on POC test implementation is recommended to explore the various facilitators of POC testing that increase service accessibility, especially in remote areas. We also recommend enhanced research to understand the challenges to POC testing implementation, particularly in the POC tests such as CD4 cell enumeration, albumin, ketones, bilirubin and white blood lactate, and thereby find potential solutions to those barriers.

Strengths and limitations

A scoping review allows the inclusion of various study designs and enables the researcher to systematically search for and choose relevant literature to describe the evidence on a study topic. In this regard, we were able to search for relevant literature and give insight into facilitators and barriers to POC test services in the LMICs. This study also allowed us to establish literature gaps which will be useful to update forthcoming research. Earnestly, this study is the first of its kind to identify literature aiming at the WHO EDL and POC test service implementation in the resource-limited settings in the LMICs. Despite the numerous strengths, the study has many limitations. The study might have missed some relevant literature because few databases were employed for data searching. Moreover, the study was limited to PHC in the LMICs. Therefore, relevant studies might have been published in other facilities and advanced countries. Again, the study was limited to only articles published on the WHO EDL POC diagnostic test, which does not allow a review of other POC tests. Notwithstanding, the study is still important to guide future research.

 

Conclusion

The study presented limited evidence of publication on the implementation of the general POC test for use in a resource-limited setting in the LMICs. It shows a research gap in general POC diagnostic tests for using health facilities without laboratories in the LMICs. Low availability of POC tests, funding and inadequate human resources remain as barriers to POC testing service implementation. It is, therefore, necessary to scale up POC testing service, particularly across rural areas of LMICs towards improving the service delivery.

 

Acknowledgements

We owe a debt of gratitude to the Health Economics and HIV/AIDS Research Division Scholarship, the Swedish International Development Cooperation Agency, and the staff of the Faculty of Health Sciences, University of KwaZulu-Natal, South Africa, for their diverse support.

Competing interests

The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.

Authors' contributions

M.A-M. and D.K. conceptualised and designed this study. M.A-M. and E.A.A. contributed to the database search and article screening. M.A-M. and D.K. contributed to the design and data extraction, as well as the data synthesis. M.A-M. wrote the manuscript. E.A.A. contributed to the writing of the manuscript. T.G.G. critically reviewed and revised the manuscript. All authors approved the final version of the manuscript.

Funding information

This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

Data availability

The authors confirm that the data supporting the findings of this study are available within the article.

Disclaimer

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of any affiliated agency of the authors.

 

References

1. Bigna JJ, Noubiap JJ. The rising burden of non-communicable diseases in sub-Saharan Africa. Lancet Glob Health. 2019;7(10):e1295-e1296. https://doi.org/10.1016/S2214-109X(19)30370-5        [ Links ]

2. Erice C. New insights into microvascular injury to inform enhanced diagnostics and therapeutics for severe malaria. Virulence. 2019;10(1):1034-1046. https://doi.org/10.1080/21505594.2019.1696621        [ Links ]

3. Young N, Achieng F, Desai M, et al. Integrated point-of-care testing (POCT) for HIV, syphilis, malaria, and anaemia at antenatal facilities in western Kenya: A qualitative study exploring end-users' perspectives of appropriateness, acceptability, and feasibility. BMC Heal Serv Res. 2019;19(1):1-15. https://doi.org/10.1186/s12913-018-3844-9        [ Links ]

4. Palmer T, Aiyenigba AO, Bates I, et al. Improving the effectiveness of point of care tests for malaria and anaemia: A qualitative study across three Ghanaian antenatal clinics. BMC Heal Serv Res. 2020;20(1):1-13. https://doi.org/10.1186/s12913-020-05274-7        [ Links ]

5. Alonso S, Chaccour CJ, Elobolobo E, et al. The economic burden of malaria on households and the health system in a high transmission district of Mozambique. Malar J. 2019;18(1):1-10. https://doi.org/10.1186/s12936-019-2995-4        [ Links ]

6. Togun T. Childhood tuberculosis in high burden settings. EBioMed. 2021;63:103181. https://doi.org/10.1016/j.ebiom.2020.103181        [ Links ]

7. Kumar S, Kumar N, Vivekadhish S. Millennium development goals (MDGs) to sustainable development goals (SDGs): Addressing unfinished agenda and strengthening sustainable development and partnership. Indian J Community Med. 2016;41(1):1-4. https://doi.org/10.4103/0970-0218.170955        [ Links ]

8. World Health Organization. Selection of essential in vitro diagnostics at country level using the WHO model list of essential in vitro diagnostics to develop and update a national list of essential in vitro diagnostics. Geneva: World Health Organization; 2021.         [ Links ]

9. World Health Organization. Second WHO model list of essential in vitro diagnostics. Geneva: World Health Organization; 2019. Available from https://www.who.int/publications/i/item/WHO-MVP-EMP-2019.05        [ Links ]

10. World Health Organization. First WHO Model List of Essential In Vitro Diagnostics. Geneva: World Health Organization; 2019. Available from https://www.who.int/publications/i/item/9789241210263        [ Links ]

11. World Health Organization. The selection and use of essential in vitro diagnostics - TRS 1031. Geneva: World Health Organization; 2021.         [ Links ]

12. World Health Organization. The selection and use of essential in vitro diagnostics: WHO Technical Report Series; 1022. Geneva: World Health Organization; 2019.         [ Links ]

13. Larsson A, Greig-pylypcsuk R, Huisman A. The state of point-of-care testing: A European perspective. Ups J Med Sci. 2015;120(1):1-10. https://doi.org/10.3109/03009734.2015.1006347        [ Links ]

14. Kuupiel D, Bawontuo V, Mashamba-Thompson TP. Improving the accessibility and efficiency of point-of-care diagnostics services in low- and middle-income countries: Lean and agile supply chain management. MDPI Diagnos. 2017;7(4):58. https://doi.org/10.3390/diagnostics7040058        [ Links ]

15. Mcgann PT, Hoppe C. The pressing need for point-of-care diagnostics for sickle cell disease: A review of current and future technologies. Blood Cells Mol Dis. 2017;67:104-113. https://doi.org/10.1016/j.bcmd.2017.08.010        [ Links ]

16. Mcfall SM, Maiga M, Glucksberg M, et al. Supporting diagnosis and management of HIV/AIDS patients through point-of-care technology development. HHS Public Access. 2020;11:9-15. https://doi.org/10.1016/j.cobme.2019.08.009        [ Links ]

17. Mcfall SM, Maiga M, Glucksberg MR, et al. C-THAN: A new research center for the development of point-of-care technology for HIV/AIDS. HHS Public Access. 2019;2(2):1-5. https://doi.org/10.15641/ghi.v2i2.822        [ Links ]

18. Sandbulte MR, Gautney BJ, Maloba M, et al. Infant HIV testing at birth using point-of-care and conventional HIV DNA PCR: An implementation feasibility pilot study in Kenya. Pilot Feasibility Stud. 2019;5(1):1-10. https://doi.org/10.1186/s40814-019-0402-0        [ Links ]

19. Sullivan SO, Ali S, Jiang X, et al. Developments in transduction, connectivity and AI/machine learning for point-of-care testing. Sensors. 2019;19(8):1917. https://doi.org/10.3390/s19081917        [ Links ]

20. Muchungusi C, Rasti R, Nanjebe D, et al. Health care workers' perceptions of point-of-care testing in a low-income country - A qualitative study in Southwestern Uganda. PLoS One. 2017;12(7):e0182005.         [ Links ]

21. Maluleke K, Dlangalala T, Musekiwa A, et al. A scoping review protocol for supply chain management systems for point of care diagnostics services: Optimising COVID-19 testing capacity in resource-limited settings. Diagnostics 2021;11(12):2299. https://doi.org/10.3390/diagnostics11122299        [ Links ]

22. Potter S. The use of point of care ultrasound in hand surgery. J Hand Surg Am. 2021;46(7):602-607. https://doi.org/10.1016/j.jhsa.2021.02.004        [ Links ]

23. Eley CV, Sharma A, Lecky DM, et al. Qualitative study to explore the views of general practice staff on the use of point-of-care reactive protein testing for the management of lower respiratory tract infections in routine general practice in England. BMJ Open. 2018;8(10):e023925. https://doi.org/10.1136/bmjopen-2018-023925        [ Links ]

24. Mashamba-Thompson TP, Jama NA, Sartorius B, et al. Implementation of point-of-care diagnostics in rural primary healthcare clinics in South Africa: Perspectives of key stakeholders. MDPI Diagn. 2017;8(3):1-12. https://doi.org/10.3390/diagnostics7010003        [ Links ]

25. Smith S, Korvink JG, Mager D, et al. The potential of paper-based diagnostics to meet the ASSURED criteria. R Soc Chem. 2018;8:34012-34034. https://doi.org/10.1039/C8RA06132G        [ Links ]

26. Pandey CM, Augustine S, Kumar S, et al. Microfluidics based point-of-care diagnostics. Biotechnol J. 2018;13(1):1-11. https://doi.org/10.1002/biot.201700047        [ Links ]

27. Kuupiel D, Tlou B, Bawontuo V, Drain PK, Mashamba-Thompson TP. Poor supply chain management and stock-outs of point-of-care diagnostic tests in Upper East Region's primary healthcare clinics, Ghana. PLoS One. 2019;14(2):1-15. https://doi.org/10.1371/journal.pone.0211498        [ Links ]

28. Fiorella C, Huaynate A, Jehnny M, et al. Diagnostics barriers and innovations in rural areas: Insights from junior medical doctors on the frontlines of rural care in Peru. BMC Health Serv Res. 2015;15(1):1-10. https://doi.org/10.1186/s12913-015-1114-7        [ Links ]

29. Katoba J, Kuupiel D, Tivani P. Toward improving accessibility of point-of-care diagnostic services for maternal and child health in low-and middle-income countries. Point Care. 2019;18(1):17-25. https://doi.org/10.1097/POC.0000000000000180        [ Links ]

30. Dassah ET, Adu-Sarkodie Y, Mayaud P. Rollout of rapid point of care tests for antenatal syphilis screening in Ghana: Healthcare provider perspectives and experiences. BMC Heal Serv Res. 2018;18(1):1-12. https://doi.org/10.1186/s12913-018-2935-y        [ Links ]

31. Everitt ML, Tillery A, David MG, et al. A critical review of point-of-care diagnostic technologies to combat viral pandemics. Anal Chim Acta. 2020;1146:184-199. https://doi.org/10.1016/j.aca.2020.10.009        [ Links ]

32. Hardy V, Thompson M, Alto W, et al. Exploring the barriers and facilitators to use of point of care tests in family medicine clinics in the United States. BMC Fam Pract. 2016;17(1):1-8. https://doi.org/10.1186/s12875-016-0549-1        [ Links ]

33. Kuupiel D, Bawontuo V, Drain PK, et al. Supply chain management and accessibility to point-of-care testing in resource-limited settings: A systematic scoping review. BMC Heal Serv Res. 2019;19(1):1-11. https://doi.org/10.1186/s12913-019-4351-3        [ Links ]

34. Melanie YJ, Simon J, Carel J, et al. Formulating design recommendations for the acceptance of the use and results of point-of-care testing in low- and middle-income countries: A literature review. Proc Des Soc Int Conf Eng Des. 2019;1(1):2795-2804.         [ Links ]

35. Tricco AC, Lillie E, Sarin W, et al. PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Ann Intern Med. 2018; 169(7):467-473.         [ Links ]

36. Huddy JR, Ni MS, Barlow J, et al. Qualitative analysis of stakeholder interviews to identify the barriers and facilitators to the adoption of point-of-care diagnostic tests in the UK. BMJ Open 2021;11(4):1-9. https://doi.org/10.1136/bmjopen-2020-042944        [ Links ]

37. Fantom NJ, Serajuddin U. The World Bank's classification of countries by income. World Bank Policy Research Working Paper. 2016(7528).         [ Links ]

38. Gupta-Wright A, Manabe YC. Implementation science: Point-of-care diagnostics in HIV. Clin Med. 2019;19(2):145-148. https://doi.org/10.7861/clinmedicine.19-2-145        [ Links ]

39. Alemnji G, Pati R, Chun H, et al. Clinical/laboratory interface interventions to improve impact of viral load and early infant diagnosis testing scale-up. AIDS Res Hum Retroviruses. 2020;36(7):550-555. https://doi.org/10.1089/aid.2019.0266        [ Links ]

40. Markwalter CF, Kantor AG, Moore CP, et al. Inorganic complexes and metal-based nanomaterials for infectious disease diagnostics. Chem Rev. 2019;119(2):1456-1518. https://doi.org/10.1021/acs.chemrev.8b00136        [ Links ]

41. Shahid I, Alsahrani AR, Al-Ghamdi SS, et al. Hepatitis C diagnosis: Simplified solutions, predictive barriers, and future promises. MDPI Diagn. 2021;11(7):1253. https://doi.org/10.3390/diagnostics11071253        [ Links ]

42. Hayward G, Dixon S, Garland S, et al. Point-of-care blood tests during home visits by out-of-hours primary care clinicians: A mixed-methods evaluation of a service improvement. BMJ Open. 2020;10(1):1-7. https://doi.org/10.1136/bmjopen-2019-033428        [ Links ]

43. Smith M, Rosenmoss S, Seligman HK. Point-of-care Hemoglobin a/c testing system in community settings: Challenges, opportunities, and measurement characteristics. Prog Community Health Partnersh. 2020;14(3):327-335. https://doi.org/10.1353/cpr.2020.0038        [ Links ]

44. Maw AM, Galvin B, Henri R, et al. Stakeholder perceptions of point-of-care ultrasound implementation in resource-limited settings. MDPI Diagn. 2019;9(4):1-11. https://doi.org/10.3390/diagnostics9040153        [ Links ]

45. Martin K, Chikwari CD, Young CRSM, et al. 'It was difficult to offer same day results': Evaluation of community-based point-of-care testing for sexually transmitted infections among youth using the GeneXpert platform in Zimbabwe. BMC Health Serv Res. 2022;22(1):1-14. https://doi.org/10.1186/s12913-022-07557-7        [ Links ]

46. Chamane N, Kuupiel D, Mashamba-Thompson T. Stakeholders' perspectives for the development of a point-of-care diagnostics curriculum in rural primary clinics in South Africa: Nominal Group Technique. MDPI Diagn. 2020;10(4):195. https://doi.org/10.3390/diagnostics10040195        [ Links ]

47. Reddy S, Gibbs A, Spooner E, et al. Assessment of the impact of rapid point-of-care CD4 testing in primary healthcare clinic settings: A survey study of client and provider perspectives. MDPI Diagn. 2020;10(2):81. https://doi.org/10.3390/diagnostics10020081        [ Links ]

48. Van Hecke O, Butler C, Mendelson M, et al. Introducing new point-of-care tests for common infections in publicly funded clinics in South Africa: A qualitative study with primary care clinicians. BMJ Open. 2019;9(11):e29260. https://doi.org/10.1136/bmjopen-2019-029260        [ Links ]

49. Ginderdeure J, Hanrahan C, Id LM, et al. Health system barriers to implementation of TB preventive strategies in South African primary care facilities. PLoS One. 2019;14(2):e0212035. https://doi.org/10.1371/journal.pone.0212035        [ Links ]

50. Rao A, Kennedy C, Mda P, et al. Patient acceptance of HIV testing services in rural emergency departments in South Africa. S Afr J HIV Med. 2020;21(1):1-9. https://doi.org/10.4102/sajhivmed.v21i1.1105        [ Links ]

51. Wexler C, Maloba M, Brown M, et al. Factors affecting acceptance of at-birth point of care HIV testing among providers and parents in Kenya: A qualitative study. PLoS One. 2019;14(11):1-17. https://doi.org/10.1371/journal.pone.0225642        [ Links ]

52. Wexler C, Kamau Y, Muchoki E, et al. Implementing at-birth, point-of-care HIV testing in Kenya: A qualitative study using the consolidated framework for implementation research. Implement Sci Commun. 2021;2(1):1-13. https://doi.org/10.1186/s43058-021-00188-9        [ Links ]

53. Macharia LW, Id CW, Id MB, et al. Implementation planning for the community-based point-of-care HIV testing for infants: Recommendations from community leaders in Kenya. PLoS One. 2020;15(10):e0240476. https://doi.org/10.1371/journal.pone.0240476        [ Links ]

54. Kuupiel D, Tlou B, Bawontuo V, et al. Accessibility of pregnancy-related point-of-care diagnostic tests for maternal healthcare in rural primary healthcare facilities in Northern Ghana: A cross-sectional survey. Heliyon. 2019;5(2):e01236. https://doi.org/10.1016/j.heliyon.2019.e01236        [ Links ]

55. Mohamed Y, Kupul M, Gare J, et al. Feasibility and acceptability of implementing early infant diagnosis of HIV in Papua New Guinea at the point of care: A qualitative exploration of health worker and key informant perspectives. BMJ Open. 2020;10(11):e043679. https://doi.org/10.1136/bmjopen-2020-043679        [ Links ]

56. Maddox BLP, Wright SS, Namadingo H, et al. Assessing stakeholder perceptions of the acceptability and feasibility of national scale-up for a dual HIV/syphilis rapid diagnostic test in Malawi. Sex Transm Infect. 2017;93(S4):S59-S64. https://doi.org/10.1136/sextrans-2016-053062        [ Links ]

57. Hershow RB, Simba CC, Mweemba O, et al. Perspectives on HIV partner notification, partner HIV self-testing and partner home-based HIV testing by pregnant and postpartum women in antenatal settings: A qualitative analysis in Malawi and Sambia. J Int AIDS Soc. 2019;22:e25293. https://doi.org/10.1002/jia2.25293        [ Links ]

58. Reipold EI, Trianni A, Krakower D, et al. Values, preferences and current hepatitis B and C testing practices in low-and -middle income countries: Results of a survey of end-users and implementers. BMC Infect Dis. 2017;17(1):149-157. https://doi.org/10.1186/s12879-017-2769-y        [ Links ]

59. Bocoum FY, Tarnagda G, Bationo F, et al. Introducing onsite antenatal syphilis screening in Burkina Faso: Implementation and evaluation of a feasibility intervention tailored to a local context. BMC Heal Serv Res. 2017;17(1):1-10. https://doi.org/10.1186/s12913-017-2325-x        [ Links ]

 

 

Correspondence:
Monica Ansu-Mensah
manvam3@yahoo.com

Received: 08 Aug. 2022
Accepted: 08 Nov. 2022
Published: 03 Feb. 2023

 

 

Appendix 1

 


Table 1-A1 - Click to enlarge

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons