SciELO - Scientific Electronic Library Online

 
vol.8 issue1 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • On index processSimilars in Google

Share


SA Orthopaedic Journal

On-line version ISSN 2309-8309
Print version ISSN 1681-150X

SA orthop. j. vol.8 n.1 Centurion Jan. 2009

 

BASIC RESEARCH ARTICLE

 

Part II: Metabolic bone disease: Recent developments in the pathogenesis of rickets, osteomalacia and age-related osteoporosis

 

 

EJ Raubenheimer

MChD, PhD, DSc; Chief Specialist: Metabolic Bone Disease Clinic, Faculty of Health Sciences, Medunsa Campus, University of Limpopo

Correspondence

 

 


ABSTRACT

The term 'metabolic bone disease' encompasses an unrelated group of systemic conditions that impact on skeletal collagen and mineral metabolism. Their asymptomatic progression leads to advanced skeletal debilitation and late clinical manifestation. This article provides a brief overview of advances in the understanding of the pathogenesis of rickets, osteomalacia and age-related osteoporosis.


 

 

“Full text available only in PDF format”

 

 

References

1. Ray NF, Chan JK, Thamer M. Medical expenditure for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Min Res 1997;12:24-35.         [ Links ]

2. Vigorita VJ. The tissue pathological features of metabolic bone disease. Orthop Clin North Am 1984;15:613-29.         [ Links ]

3. Amala I. The use of histological methods in studies of osteoporosis. Calcif Tissue Int 1991;49(Suppl):531-2.         [ Links ]

4. Raubenheimer EJ. Part I: Metabolic bone disease: histomorphometry as a diagnostic aid. SA Orthop J 2008;7(4):19-23.         [ Links ]

5. Pettifor JM Nutritional rickets: deficiency of vitamin D, calcium or both? Am J Clin Nutr 2004;80(6Suppl):1725S-9S.         [ Links ]

6. Tacher TD, Fischer PR, Strand MA, Pettifor JM. Nutritional rickets around the world: Causes and future directions. Ann Trop Paediatr 2006;236(1):1-16.         [ Links ]

7. Eisman JA. Genetics of osteoporosis. Endocrine Rev 1999;20:788-804.         [ Links ]

8. Spiller G, Story JA, Wong LG, et al. Effect of increasing levels of hard wheat fibre on fecal weight, minerals and steroids and gastrointestinal transit time in healthy young women. J Nutrition 1986;116:778-85.         [ Links ]

9. Weaver CM, Heaney RP, Teegarden D et al. Wheat bran abolishes the inverse relationship between calcium load size and absorption fraction in women. J Nutrition 1996;126:303-7.         [ Links ]

10. Batchelor AJ, Compston JE. Reduced plasma half life of radio-labelled 25-hydroxyvitamin D, in subjects receiving high fibre diet. Br J Nutr 1983;49:213-6.         [ Links ]

11. Moskilde L. Vitamin D requirement and setting recommendation levels: long term perspectives. Nutr Rev 2008;66(10 suppl.):S170-7.         [ Links ]

12. Iuliano-Burns S, Wang XF, Ayton J, Jones G, Seeman E. Skeletal and hormonal responses to sunlight deprivation in Antarctic expeditioners. Osteoporos Int 2009; In print.         [ Links ]

13. Lee WT, Jiang J. The resurgence of the importance of vitamin D in bone health. Asia Pac J Clin Nutr 2008;17(suppl.1):138-42.         [ Links ]

14. Bruyere O, Decock C, Delhez M, Colette J, Reginster JY. Highest prevalence of vitamin D inadequacy in institutionalized women compared with noninstitutionalized women: a case control study. Womens Health (Lond Engl) 2009;5(1):49-54.         [ Links ]

15. Poduje S, Sjerobabski-Masnec I, Ozanic-Bullic S. Vitamin D -the true and the false about vitamin D. Coll Antropol 2008;32 (Suppl. 2):159-62.         [ Links ]

16. Yu CK, Sykes L, Sethi M, Teoh TG, Robinson S. Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol (Oxf) 2008; In Print.         [ Links ]

17. Dent CE, Stamp CB. Vitamin D, rickets and osteomalacia. In: Avioli LV, Krane SM, eds. Metabolic Bone Disease. Vol. I. New York: Academic Press; 1977:237-305.         [ Links ]

18. Bisballe S, Eriksen EF, Melsen F et al. Osteopaenia and osteo-malacia after gastrectomy: interrelations between biochemical markers of bone remodeling, vitamin D metabolites and bone histomorphometry. Gut 1991;32:1303-7.         [ Links ]

19. Dewar DH, Ciclitira PJ. Clinical features and diagnosis of celiac disease. Gastroenterology 2005;128(4 suppl 1):S19-24.         [ Links ]

20. Dujuskova H, Drte P, Tomandl J, Sevekova A, Precechtelova M. Occurrence of metabolic osteopathy in patients with chronic pancreatitis. Pancreatology 2008;8(6):583-6.         [ Links ]

21. Zuberi LM, Habib A, Haque N, Jabbar A. Vitamin D deficiency in ambulatory patients. J Pak Med Assoc 2008;58(9): 482-4.         [ Links ]

22. Mekherjee A, Bhattacharyya AK, Sarkar PK, Mondal AK. Kwashiorkor-Marasmus syndrome and nutritional rickets - a bone biopsy study. Trans Royal Soc Trop Med Hyg 1991;85:688-9.         [ Links ]

23. Weinstein RS, Bell NH. Diminished rates of bone formation in normal Black adults. N Engl J Med 1988;319:1698-1701.         [ Links ]

24. Haeney RP, Layman DK. Amount and type of protein influences bone health. Am J Clin Nutr 2008;87(5):1567S-70S.         [ Links ]

25. Mazess RB. On ageing bone loss. Clin Orthop Rel Res 1982;165:239-52.         [ Links ]

26. Jackson JA, Kleerekoper M. Osteoporosis in men: Pathophysiology and prevention. Medicine (Baltimore) 1990; 69: 137-52.         [ Links ]

27. Weitzmann MN, Pacifici R. Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest 2006;116(6):1186-94.         [ Links ]

28. Gennari L, Nuti R, Bilezikian JP. Aromatase activity and bone homeostasis in men. J Clin Endocrinol Metab 2004; 89(12):5898-907.         [ Links ]

29. Kearns AE, Khosta S. Potential anabolic effects of androgen on bone. Mayo Clin Proc 2004;79(4 suppl):S41-8.         [ Links ]

30. Delichatsios HK, Lane JM, Rivlin RS. Bone histomorphometry in men with spinal osteoporosis. Calcif Tissue Int 1995;56:359-63.         [ Links ]

31. Turner RT, Wakley GK, Hannon KS. Differential effect of androgens on cortical bone histomorphometry in gonadectomized male and female rats. J Orthop Res 1990;8:612-17.         [ Links ]

32. Riggs BL, Melton LJ. Evidence of two distinct syndromes of involutional osteoporosis (editorial). Am J Med 1983;75:899-902.         [ Links ]

33. Parfitt AM, Matthews CHE, Villaneauve AR, et al. Relationship between surface, volume and thickness of iliac trabecular bone in ageing osteoporosis. J Clin Invest 1983;72:1396-409.         [ Links ]

34. Bachrach LK, Consensus and controversy regarding osteoporosis in the pediatric population. Endocr Pract 2007;13(5):513-20.         [ Links ]

35. Rubin CT, Gross TS, Mcleod KJ, et al. Morphologic stages in lamellar bone formation stimulated by potent mechanical stimulus. J Bone Miner Res 1995;10:488-95.         [ Links ]

36. Avioli LV. Osteoporosis: pathogenesis and therapy. In: Avioli LV, Krane SM (eds). Metabolic bone disease. Vol I. New York: Academic Press;1977:307-70.         [ Links ]

37. Cavolina JM, Evans GL, Harris SA et al. The effects of orbital space flight on bone histomorphometry and messenger ribonucleic acid levels for bone matrix proteins and skeletal signaling peptides in overectomized growing rats. Endocrinology 1997; 138:1567-76.         [ Links ]

38. Cormier C. Epidemiology, diagnosis and treatment of osteoporosis. Curr Opin Rheumatol 1994;6:329-35.         [ Links ]

39. Creedon A, Flynn A, Cashman K. The effect of moderately to severely restricted dietary magnesium intakes on bone composition and bone metabolism in the rat. Br J Nutr 1999;82:63-71.         [ Links ]

40. Ettinger B, Ensrud KE, Wallace R, Johnson KC, Cummings SR, Yankov V, Vittinghoff E, Grady D. Effects of ultralow-dose transdermal estradiol on bone mineral density: a randomized clinical trial. Obstet Gynecol 2004;104(3):443-51.         [ Links ]

41. Zerewekh JE, Hagler HK, Sakhae K et al. Effect of slow-release sodium fluoride on cancellous bone histology and connectivity in osteoporosis. Bone 1994;15:691-9.         [ Links ]

42. Phipps KR, Orwoll ES, Bevan L. The association between water-borne fluoride and bone mineral density in older adults. J Dent Res 1998;77:1739-48.         [ Links ]

43. Hodgson JM, Devine A, Burke V, Dick IM, Prince RL. Chocolate consumption and bone density in older women. Am J Clin Nutr 2008;87(1):175-80.         [ Links ]

44. Devine A, Hodgson JM, Dick IM, Prince RL. Tea drinking is associated with benefits on bone density in older women. Am J Clin Nutr 2007;86(4):1243-7.         [ Links ]

 

 

Correspondence:
Prof EJ Raubenheimer
Room FDN324
MEDUNSA Campus: University of Limpopo
0204
South Africa
Tel: (012) 521-4838
Email: ejraub@ul.ac.za

 

 

Part I of this article was published in SA Orthopaedic Journal 2008, Vol. 7, No. 4.
The content of this article is the sole work of the authors. No benefits of any form have been derived from any commercial party related directly or indirectly to the subject of this article.

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License