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SA Orthopaedic Journal

On-line version ISSN 2309-8309
Print version ISSN 1681-150X

SA orthop. j. vol.7 n.1 Pretoria Jan./Mar. 2008




Pathological sacral fracture in type 1 neurofibromatosis



AW HumanI; Prof S GovenderII

IMBChB (Pret) Registrar. Head of Department
IIMBBS, MD, FRCS. Department of Orthopaedic Surgery, Nelson R Mandela School of Medicine, University of KwaZulu-Natal

Reprint requests




Neurofibromatosis (NF) type 1 is one of the most common neurocutaneous disorders. This autosomal dominant genetic disorder is due to an abnormality on chromosome 171 that leads to abnormal neural crest cell proliferation. Neurofibromas account for 16-30% of all spinal tumours,2 occurring most commonly in the thoracic region, followed by cervical and lumbar region. Only 1-5% occur in the sacral region. We report a sacral fracture due to a neurofibroma in a child with type 1 neurofibromatosis.



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Reprint requests:
Prof S Govender
Department of Orthopaedic Surgery, University of KZN
Nelson R Mandela School of Medicine
Private Bag X7, Congella, 4013
Tel: (031) 260-4297; Fax: (031) 260-4518



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