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Journal of the South African Veterinary Association

versão On-line ISSN 2224-9435

J. S. Afr. Vet. Assoc. vol.80 no.4 Cape Town  2009

 

CLINICAL COMMUNICATION KLINIESE MEDEDELING

 

Large granular lymphocytic leukaemia complicated with histiocytic sarcoma in a dog

 

 

T MaruoI; K NamikawaI, II; A KunihiroIII; J LynchIV; T ShidaI, II; S KishikawaIV

IVeterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan
IISchool ofVeterinaryMedicine, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan
IIIMomo Animal Clinic 1-8-9 Nakamachidai, Tsuzukiku, Yokohama, Kanagawa 224-0041, Japan
IVSchool of Life and Environment Science, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan

 

 


ABSTRACT

A 10-year-old castrated male Golden retriever, weighing 36.3 kg was referred for evaluation owing to a decline in general condition. Findings from the complete blood count revealed a marked lymphocytosis (113 000/µl). Examination of Wright-Giemsa-stainedfilms of peripheral blood revealed the presence of large granular lymphocytes (LGL). Seventy-two per cent (81 360/µl) of the lymphocytes were found to be 12-17 µm in diameter, containing nuclei with mature clumped chromatin and abundant lightly basophilic cytoplasm with a variable number of fine azurophilic granules. Based on these findings this case was diagnosed as LGL leukaemia. As a result of multiple-agent chemotherapy, the markedly elevated levels of lymphocytes gradually decreased to 7500/µl on day 122 and the patient maintained a good quality of life for the following 3 months. However, on around day 237, a soft, raised, bosselated mass on the labial region was noted. The dog was diagnosed as having histiocytic sarcoma based on cytological and histological examination of the mass. Shortly after diagnosis, the dog developed sudden onset of central nervous system signs and died on day 270. A common outcome of canine LGL is the development of acute blast crisis or lymphoma. However, this case was notable for complication with histiocytic sarcoma from another origin.

Keywords: dog, histiocytic sarcoma, large granular lymphocytic leukaemia


 

 

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REFERENCES

1. Carioto L 1997 Malignant histiocytosis in a Bernese mountain dog presenting as a mandibular mass. Canadia Veterinary Journal 38: 105-107        [ Links ]

2. ChandraAMS, Ginn P E 1999 Primary malignant histiocytosis of the brain in a dog. Journal of Comparable Pathology 121: 77-82        [ Links ]

3. Hayden D W, Waters D J, Burke B A, Manivel J C 1993 Disseminated malignant histiocytosis in a Golden retriever: clinico-pathologic, ultrastructural, and immuno-histochemical findings. Veterinary Pathology 30: 256-264        [ Links ]

4. Heeb H L, Wilkerson M J, Chun R, Ganta R R 2003 Large granular lymphocytosis, lymphocyte subset inversion, thrombo-cytopenia, dysproteinemia, and positive Ehrlichia serology in a dog. Journal of the American Animal Hospital Association 39: 379-384        [ Links ]

5. Jain N C 1993 The lymphocytes and plasma cells. In: Jain N C (ed.) Essentials of veterinary hematology. Lea & Febiger, Philadelphia: 278-294        [ Links ]

6. Lau K W M, Kruth S A, Thorn C E, Vernau W, Moore P 1999 Large granular lymphocytic leukemia in a mixed breed dog. Canadian Veterinary Journal 40: 725-728        [ Links ]

7. McDonough S P, Moore P F 2000 Clinical, hematologic, and immunophenotypic characterization of canine large granular lymphocytosis. Veterinary Pathology 37: 637-646        [ Links ]

8. Mylonakis M E, Koutinas A F, Papaioannou N, Lekkas S 2007 Acute tumor lysis syndrome in a dog with B-cell multicentric lymphoma. Australian Veterinary Journal 85: 206-208        [ Links ]

9. Ramirez S, Douglass J P Robertson ID 2002 Ultrasonographic features of canine abdominal malignant histiocytosis. Veterinary Radiology & Ultrasound 43: 167-170        [ Links ]

10. Ramsey I K, McKay J S, Rudorf H, Dobson J M 1996 Malignant histiocytosis in three Bernese mountain dogs. Veterinary Record 138: 440-444        [ Links ]

11. Skorupski K A, Clifford C A, Paoloni M C, Lara-Garcia A, Barber L, Kent M S, LeBlanc A K, Sabhlok A, Mauldin E A, Shofer F S, Couto C G, Srenmo K U 2007 CCNU for the treatment of dogs with histiocytic sarcoma. Journal of Veterinary Internal Medicine 21: 121-126        [ Links ]

12. Snead E C 2007 Large granular intestinal lymphosarcoma and leukemia in a dog. Canadian Veterinary Journal 48: 848-851        [ Links ]

13. Takahashi T, Otani I, Okuda M, Inoue M, Ito K, Sakai M, Koie H, Yamaya Y, Watari T, Sato T, Kanayama K, Tokuriki M 2007 Malignant transformation of T-cell large granular lymphocyte leukemia in a dog. Journal of Veterinary Medical Science 69: 677-681        [ Links ]

14. Vernau W, Moore P F 1999 An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase chain reaction. Veterinary Immunology and Immunopathology 69: 145-164        [ Links ]

15. Vickery K R, Thamm D H 2007 Successful treatment of acute tumor lysis syndrome in a dog with multicentric lymphoma. Journal of Veterinary Internal Medicine. 21: 1401-1404        [ Links ]

16. Workman H C, Vernau W 2003 Chronic lymphocytic leukemia in dogs and cats: the veterinary perspective. Veterinary Clinics of North America: Small Animal Practice 33: 1379-1399        [ Links ]

 

 

Received: June 2009
Accepted: November 2009

 

 

* Author for correspondence. E-mail: namikawa@azabu-u.ac.jp

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