REVIEW ARTICLE OORSIGARTIKEL

'Emerging' mycobacteria in South Africa

P D van Helden; S D C Parsons; N C Gey van Pittius

DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology/Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, 7505 South Africa

ABSTRACT

Disease can be caused by various species of the genus Mycobacterium. A number of reports, both published and unpublished, of rarely reported mycobacteria have surfaced in South Africa in the last few years. Some unusual hosts have also been involved, causing concern in some quarters.These include reports on Mycobacterium goodii in a spotted hyaena (Crocuta crocuta), M. xenopi in a ruffed lemur (Varecia variegata), M. intracellulare in wild-caught chacma baboons (Papio ursinus), the 'dassie bacillus' in free ranging rock hyrax (dassies; Procavia capensis) the 'oryx bacillus' from free-ranging buffalo (Syncerus caffer) and M. tuberculosis in suricates (Suricata suricatta), a domestic dog and in baboons. In this article it has been attempted to put these in context and show how improved surveillance and technologies have allowed mycobacteria to be identified to species level more easily. Most of the unusual mycobacterial species have most likely been present in the region for many years and have probably caused disease episodes before, but have been misdiagnosed. Each case must be evaluated carefully with respect to the animal species involved, the environment in which the host is found and the mycobacterial species, and operational decisions made accordingly.

Keywords: animalia, Mycobacteria, speciation, tuberculosis

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REFERENCES

1. Chege G K, Warren R M, Gey van Pittius N C, Burgers W A, Wilkinson R J, Shephard E G, Williamson A L 2008 Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN- ELISPOT tests following a tuberculosis outbreak. BMC Microbiology 8: 27        [ Links ]

2. Cousins D V, Peet R L, Gaynor W T, Williams S N, Gow B L 1994 Tuberculosis in imported hyrax (Procavia capensis) caused by an unusual variant belonging to the Mycobacterium tuberculosis complex. Veterinary Microbiology 42: 135-145        [ Links ]

3. Euzéby J P List of Prokaryotic names with Standing in Nomenclature (LPSN). Online at: http://www.bacterio.cict.fr/ (accessed January 2010)        [ Links ]

4. Gandhi N R, Moll A, Sturm A W, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G 2006 Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368: 1575-1580        [ Links ]

5. Hammond P M, Allsopp D, Colwell R R, Hawksworth D L 2009 Microbial diversity and ecosystem function. CABI Publishers, Wallingford: 29-71        [ Links ]

6. Hanekom M, van der Spuy G D, Gey van Pittius N C, McEvoy C R, Ndabambi S L, Victor T C, Hoal E G, van Helden P D, Warren R M 2007 Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent. Journal of Clinical Microbiology 45: 2263-2266        [ Links ]

7. Huard R C, Fabre M, de Haas P, Lazzarini L C, van Soolingen D, Cousins D, Ho J L 2006 Novel genetic polymorphisms that further delineate the phylogeny of the Mycobacterium tuberculosis complex. Journal of Bacteriology 188: 4271-4287        [ Links ]

8. Johnson R, Warren R, Strauss O J, Jordaan A M, Falmer A A, Beyers N, Schaaf H S, Murray M, Cloete K, van Helden P D, Victor T C 2006 An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the western Cape, South Africa. International Journal of Tuberculosis and Lung Disease 10: 1412-1414        [ Links ]

9. Johnson R, Warren R M, van der Spuy G D, Gey van Pittius N C, Theron D, Streicher E M, Bosman M, Coetzee G J, van Helden P D, Victor T C 2010 Drug-resistant tuberculosis epidemic in the Western Cape driven by a virulent Beijing genotype strain. International Journal of Tuberculosis and Lung Disease 14: 119-121        [ Links ]

10. Mahomed H, Hughes E J, Hawkridge T, Minnies D, Simon E, Little F, Hanekom W A, Geiter L, Hussey G D 2006 Comparison of mantoux skin test with three generations of a whole blood IFN-gamma assay for tuberculosis infection. International Journal of Tuberculosis and Lung Disease 10: 310-316        [ Links ]

11. McCray E, Weinbaum C M, Braden C R, Onorato I M 1997 The epidemiology of tuberculosis in the United States. Clinics in Chest Medicine 18: 99-113        [ Links ]

12. Michel A L, de Klerk L M, Gey van Pittius N C, Warren R M, van Helden PD2007 Bovine tuberculosis in African buffaloes: observations regarding Mycobacterium bovis shedding into water and exposure to environmental mycobacteria. BMC Veterinary Research 3: 23        [ Links ]

13. Michel A L, Venter L, Espie I W, Coetzee M L 2003 Mycobacterium tuberculosis infections in eight species at the National Zoological Gardens of South Africa, 1991-2001. Journal of Zoo and Wildlife Medicine 34: 364-370        [ Links ]

14. Narang R, Narang P, Mendiratta D K 2009 Isolation and identification of nontuberculous mycobacteria from water and soil in central India. Indian Journal of Medical Microbiology 27: 247-250        [ Links ]

15. Parsons S D C, Gous T A, de Villiers C, Warren R M, Seier J V, van Helden P D 2009 Detection of Mycobacterium tuberculosis infection in chacma baboons (Papio ursinus) using the QuantiFERON-TB Gold (In-Tube Method) assay. Journal of Medical Primatology 38: 411-417        [ Links ]

16. Parsons S D C, Gous T A, Warren R M, van Helden P D 2008 Pulmonary Mycobacterium tuberculosis (Beijing strain) infection in a stray dog. Journal of the South African Veterinary Association 79: 95-98        [ Links ]

17. Parsons S, Smith S G D, Martins Q, Horsnell W G C, Gous T A, Streicher E M, Warren R M, van Helden P D, Gey van Pittius N C 2008 Pulmonary infection due to the dassie bacillus (Mycobacterium tuberculosis complex sp.) in a free-living dassie (rock hyrax -Procavia capensis) from South Africa. Tuberculosis 88: 80-83        [ Links ]

18. Petrini B 2006 Non-tuberculous mycobacterial infections. Scandinavian Journal of Infectious Diseases 38: 246-255        [ Links ]

19. Reichel R 1995 South Africa. In Thoen C O, Steele J H (eds) Mycobacterium bovis infection in animals and man. Iowa State University Press, Ames: 285-292        [ Links ]

20. Richter E, Weizenegger M, Fahr A M, Rusch-Gerdes S 2004 Usefulness of the GenoType MTBC assay for differentiating species of the Mycobacterium tuberculosis complex in cultures obtained from clinical specimens. Journal of Clinical Microbiology 42: 4303-4306        [ Links ]

21. Santos R, Fernandes J, Fernandes N, Oliveira F, Cadete M 2007 Mycobacterium parascrofulaceum in acidic hot springs in Yellowstone National Park. Applied Environmental Microbiology 73: 5071-5073        [ Links ]

22. Smith N H, Kremer K, Inwald J, Dale J, Driscoll J R, Gordon S V, van Soolingen D, Glyn Hewinson R, Maynard Smith J 2006 Ecotypes of the Mycobacterium tuberculosis complex. Journal of Theoretical Biology 239: 220-225        [ Links ]

23. Van der Spuy G D, Kremer K, Ndabambi S L, Beyers N, Dunbar R, Marais B J, van Helden P D, Warren R M 2009 Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics. Tuberculosis 89: 120-125        [ Links ]

24. Van Helden P D, Gey van Pittius N C, Warren R M, Michel A, Hlokwe T, Morar D, Godfroid J, du Plessis E C, Bengis R 2008 Pulmonary infection due to Mycobacterium goodii in a spotted hyena (Crocuta crocuta) from South Africa. Journal of Wildlife Diseases 44: 151-154        [ Links ]

25. Waksman S A 1964 The conquest of tuberculosis. University of California Press, Berkeley and Los Angeles        [ Links ]

26. Walker J J, Spear J R, Pace N R 2005 Geobiology of a microbial endolithic community in the Yellowstone geothermal environment. Nature 434: 1011-1014        [ Links ]

27. Whitman W B, Coleman D C, Wiebe W J 1998 Prokaryotes: the unseen majority. Proceedings of the National Academy of Sciences USA 95: 6578-6583        [ Links ]

Received: June 2009
Accepted: November 2009

* Author for correspondence. E-mail: pvh@sun.ac.za