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Journal of the South African Veterinary Association

On-line version ISSN 2224-9435
Print version ISSN 1019-9128

J. S. Afr. Vet. Assoc. vol.80 n.2 Pretoria  2009




A retrospective investigation of canine adenovirus (CAV) infection in adult dogs in Turkey



S GürI; A AcarII

IDepartment of Virology, Faculty of Veterinary Medicine, Afyon Kocatepe University, ANS Campus, 03200, Afyonkarahisar, Turkey
IIDepartment of Internal Diseases, Faculty of Veterinary Medicine, Afyon Kocatepe University, ANS Campus, 03200, Afyonkarahisar, Turkey




Canine adenovirus (CAV) type 1 and 2, respectively, cause infectious canine hepatitis and infectious canine laryngotracheitis in members of the families Canidae and Ursidae worldwide. Both of these infections are acute diseases, especially in young dogs. The aim of this study was to conduct a serological investigation of canine adenovirus infection. For this purpose, serum samples were collected from native pure-bred Kangal (n = 11), and Akbash dogs (n = 17) and Turkish Greyhounds (n = 15) in Eskisehir and Konya provinces. None of the dogs were previously vaccinated against CAV types. Indirect ELISA detected 88.2 %, 93.3 % and 100 % prevalences in Akbash, Greyhound and Kangal dogs, respectively. The remainder of the samples (n = 51) were collected at the Afyonkarahisar Municipality Shelter. Fourty-two of these dogs (82.3 %) were detected as seropositive. In total, 82 of 94 dogs (87.2 %) were found to be positive for CAV serum antibodies.

Keywords: antibody, canine adenovirus, dog, Turkey



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1. Appel M J 1987 Canine adenovirus type 1 (infectious canine hepatitis virus). In Horzinek M C (ed.) Virus infections of vertebrates, Vol. I. Virus infections of carnivores. Elsevier Science Publishers, Amsterdam: 29-43        [ Links ]

2. Assaf R, Marsolais G, Yelle J, Hamelin C 1983 Unambiguous typing of canine adenovirus isolates by deoxirybonucleic acid restriction-endonuclease analysis. Canadian Journal of Comparative Medicine 47: 460-463        [ Links ]

3. Binn L N, Eddy G A, Lazar E C, Helms J, Murnane T 1967 Viruses recovered from laboratory dogs with respiratory disease. Proceedings of the Society for Experimental Biology and Medicine 126: 140-145        [ Links ]

4. Böhm M, Thompson H, Weir A, Hasted A M, Maxwell N S, Herrtage M E 2004 Serum antibody titres to canine parvovirus, adeno-virus and distemper virus in dogs in the UK which had not been vaccinated for at least 3 years. Veterinary Record 154: 457-463        [ Links ]

5. Cabasso V J, Wilner B I 1969 Adenoviruses of animals other than man. Advances in Veterinary Science and Comparative Medicine 13: 159-217        [ Links ]

6. Cabasso V J 1981 Infectious canine hepatitis. In Davis J W, Karstad L H, Trainer D O (eds) Infectious diseases of wild mammals (2nd edn). Iowa State University Press, Ames, Iowa: 191-195        [ Links ]

7. Carmichael L E 1964 The pathogenesis of ocular lesions of infectious canine hepatitis. I. Pathology and virological observation. Pathologia Veterinaria 1: 73-95        [ Links ]

8. Carmichael L E 1965 The pathogenesis of ocular lesions of infectious canine hepatitis. II. Experimental ocular hypersensitivity produced by the virus. Pathologia Veterinaria 2: 344-359        [ Links ]

9. Castleman W L 1985 Bronchiolitis obliterans and pneumonia induced in young dogs by an experimental adenovirus infection. American Journal of Pathology 119: 495-504        [ Links ]

10. Caudell D, Confer A W, Fulton R W, Berry A, Saliki J T, Fent G M, Ritchey J W 2005 Diagnosis of infectious canine hepatitis virus (CAV-1) infection in puppies with encephalopathy. Journal of Veterinary Diagnostic Investigation 17: 58-61        [ Links ]

11. Curtis R, Barnett K C 1981. Canine adeno-virus-induced ocular lesions in the Afghan hound. Cornell Veterinarian 71: 85-95        [ Links ]

12. Ditchfield J, MacPherson L W, Zbitnew A 1962 Association of a canine adenovirus (Toronto A26/61) with an outbreak of laryngotracheitis (kennel cough). A preliminary report. Canadian Veterinary Journal 3: 238-247        [ Links ]

13. Emery J B, House J A, Brown W R 1978 Cross-protective immunity to canine adeno-virus type-2 by canine adenovirus type-1 vaccination. American Journal of Veterinary Research 39: 1778-1783        [ Links ]

14. Erdogan Mözbeyaz C 2004 Investigation of blood protein polymorphism and estimation of genetic distances in some dog breeds in Turkey. Turkish Journal of Veterinary and Animal Science 28: 583-590        [ Links ]

15. Green C 1990 Infectious canine hepatitis. In Green C E (eds) Infectious diseases of dog and cat. W B Saunders, Philadelphia: 242-251        [ Links ]

16. Murphy F A, Gibbs E P J, Horzinek M C, Studdert M J 1999 Veterinary Virology, (3rd edn). Academic Press, San Diego: 327-332        [ Links ]

17. Nelson D D 1996 A general classification of the native dogs of Turkey. In International Symposium on Turkish Shepherd Dogs, Selcuk University, Konya, Turkey, 23 October 1996: 19-94        [ Links ]

18. Noon K F, Rogul M, Binn L N, Kefe T J, Marchwicki R H, Thomas R, De Cicco B T 1979 An enzyme-linked immunosorbent assay for the detection of canine antibodies to canine adenoviruses. Laboratory Animal Science 29: 603-609        [ Links ]

19. Okuyan M 1975 High incidence of infectious canine hepatitis antibodies in the Turkish population and its relation to Au antigen. Mikrobiyoloji Bülteni 9: 101-112        [ Links ]

20. Rubarth S 1947 An acute virus disease with liver lesions in dogs (hepatitis contagiosa canis): a pathologico-anatomical and etiological investigation. Acta Pathologica Microbiologica Scandinavica, Supplement 69: 9-207        [ Links ]

21. Sasaki N, Nakai M, Iwamoto I, Konishi S, Ikegami T 1956 Studies on infectious hepatitis of dogs. II. The distribution of the disease in Japan, and its immunisation. Japan Journal of Veterinary Science 18: 113-118        [ Links ]

22. Wright N G, Cornwell H J, Thompson H, Armitage A, Morrison I 1972 Canine adenovirus respiratory disease: isolation of infectious canine hepatitis virus from natural cases and the experimental production of the disease. Veterinary Record 90: 411-416        [ Links ]

23. Wright N G 1976 Canine adenovirus: its role in renal and ocular disease: a review. Journal of Small Animal Practice 17: 25-33        [ Links ]



Received: October 2008
Accepted: June 2009



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