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Journal of the South African Veterinary Association

versão On-line ISSN 2224-9435
versão impressa ISSN 1019-9128

J. S. Afr. Vet. Assoc. vol.79 no.4 Pretoria  2008




Increasing ketamine dose enhances the anaesthetic properties of ketamine-xylazine-midazolam combinations in growing pigs



R A AjadiI; O F SmithII; A F M MakindeI; O E AdeleyeI

ICollege of Veterinary Medicine, University of Agriculture. Abeokuta, Ogun State, Nigeria
IICollege of Animal Science, University of Agriculture. Abeokuta, Ogun State, Nigeria




The influence of increasing the dosage of ketamine on anaesthesia induced by a combination of ketamine, xylazine and midazolam in pigs was determined by assessing the onset of action (OAN), duration of analgesia (DAN), anaesthesia time (ANT), and recovery time (RCT) in 10 growing pigs (Mean weight: 18.2 ± 1.65 kg) receiving either 10 mg/kg intramuscular (i.m) injection of 10 % ketamine, 2 mg/kg i.m injection of 2 % xylazine and 0.25 mg/kg i.m injection of 0.1 % midazolam (K10XM) or 20 mg/kgi.m injection of ketamine and 2 mg/kg i.m injection of xylazine and 0.25 mg/kg i.m injection of 0.1 % midazolam (K20XM). In addition, the heart rates (HR), respiratory rates (RR) and rectal temperatures (RT) were determined immediately after drug administration and at 10 minute intervals over a period of 60 minutes. Analgesia was assessed by the response of the pigs to artery forceps applied at the interdigital space. Recovery was determined as pigs' ability to stand without ataxia. Data were expressed as mean ± SEM while anaesthetic indices were compared using Student's t-tests. A P value of 0.05 was accepted as significant in all cases. In this study, both the OAN and RCT were significantly (P < 0.05) shorter in K10XM (1.4 ± 0.2 min; 7.8 ± 2.2 min) than in K20XM (2.2 ± 0.2; 18.6 ± 1.4 min) respectively. Similarly, the duration of anaesthesia was significantly (P < 0.05) shorter in K10XM (55.4 ± 8.4 min) than in K20XM (92.0 ± 13.6 min). The pigs that received K20XM combination had analgesia of duration of 41.4 ± 12.6 min while those that received K10XM combination had no analgesia. However, the HR, RR, and RT were not significantly (P > 0.05) different between K10XM and K20XM. It was therefore concluded that the lower dose ketamine combination is better for the induction of anaesthesia, while the higher dose ketamine combination is preferable for surgery of short duration in pigs.

Key words: anaesthesia, pigs, ketamine, midazolam, swine, xylazine



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1. Hedenqvist P, Roughan, J V Antunes, L M 2001 Assessment of ketamine/medetomidine in the New Zealand white rabbit. Veterinary Anaesthesia and Analgesia 28: 18-25        [ Links ]

2. Kim M J, Park C S, Jun M H, Kim M C 2007 Antagonistic effects of yohimbine in pigs anaesthetized with tiletamine/zolazepam andxylazine. Veterinary Record 161: 620-624        [ Links ]

3. Ko J C, Williams B L, Smith V L, McGrath C J, Jacobson J D 1993 Comparison of telazol, telazol-ketamine, telazol-xylazine and telazol-ketamine-xylazine chemical restraint and anaesthetic induction in swine. Laboratory Animal Science 43: 476-480        [ Links ]

4. Ko J C, Williams, B L, Rogers E R, Pablo L S, McCaine W C, McGrath C J 1995 Increasing xylazine dose enhanced anaesthetic properties of telazol-xylazine combination in swine. Laboratory Animal Science 45: 290-294        [ Links ]

5. Lin H C 1996 Dissociative anesthetics. In Thurmon J C, Tranquilli W J, Benson G J (eds) Lumb and Jones veterinary anesthesia (3rd edn). Williams & Wilkins, Baltimore: 241-296        [ Links ]

6 Sakaguchi M, Nishimura R, Sasaki N, Ishiguro T et al. 1996. Anaesthesia induced in pigs by use of a combination of medetomidine, butorphanol and ketamine and its reversal by administration of atipemazole. American Journal of Veterinary Research 57: 529-534        [ Links ]

7. Sweitzer R A, Ghneim G S, Gardner I A, Van Vuren D, Gonzales B J, Boyce W M 1997 Immobilization and physiological parameters associated with chemical restraint of wild pigs with telazol and xylazine hydrochloride. Journal of Wildlife Diseases 33: 198-205        [ Links ]

8. Wagner A E, Helleyer P W 2000 Survey of anesthetic techniques and concerns in private veterinary practice. Journal of American Veterinary Medical Association 217: 1652-1657        [ Links ]



Received: September 2008
Accepted: November 2008



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