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Journal of the South African Veterinary Association

versão On-line ISSN 2224-9435

J. S. Afr. Vet. Assoc. vol.79 no.3 Cape Town  2008

 

ARTICLE ARTIKEL

 

Thermal, cardiorespiratory and cortisol responses of impala (Aepyceros melampus) to chemical immobilisation with 4 different drug combinations

 

 

L C R MeyerI; R S HetemI; L G FickI; A MattheeII; D MitchellI; A FullerI

IBrain Function Research Group, School of Physiology, University of the Witwatersrand, 7 York Road, Parktown, 2193 South Africa
IINational Zoological Gardens Lichtenburg Game Breeding Centre, PO Box 716, Lichtenburg, 2740 South Africa

 

 


ABSTRACT

Thermometric data loggers were surgically implanted in 15 impala (Aepyceros melampus)to investigate the consequences of chemical capture. Impala were darted and chemically immobilised for 30 min with each of the following drug combinations: etorphine and azaperone; etorphine and medetomidine; thiafentanil and azaperone, and a thiafentanil medetomidine combination. During immobilisation, pulse oximeter readings, respiratory rhythm, the plane of immobilisation and plasma cortisol concentrations were measured and recorded. The impala developed an extremely high rise in body temperature, which peaked 20-30 min after reversal of the immobilisation. The magnitude of the rise in body temperature was similar for all the drug combinations (F = 0.8, P = 0.5), but the duration of the hyperthermia was shorter when the thiafentanil and azaperone combination was used (F = 3.35, P < 0.05). Changes in body temperature were related to the time that it tookfor an animal to become recumbent after darting (r2 = 0.45, P = 0.006) and not to the effect of the drug combination on time to recumbency (r2 = 0.29, P = 0.46). The relationship between time to recumbency and body temperature change, and also to plasma cortisol concentration (r2 = 0.67, P = 0.008), indicated that physiological consequences of capture were related to the duration of exposure to a stressor, and not to the pharmacology of the capture drugs. Although shorter time to recumbency in individuals resulted in the benefit of smaller stress responses and body temperature changes, those individuals were predisposed to developing hypoxia and possibly induction apnoea. When animals are chemically immobilised, reducing the thermal consequences of capture requires limiting the exposure of the animal to a psychological 'fright stress'.

Key words: body temperature, stress, etorphine, thiafentanil, medetomidine, azaperone, stress-induced hyperthermia, impala (Aepyceros melampus)


 

 

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REFERENCES

1. Burroughs R E J 1993 Chemical capture of antelope. In McKenzie A A (ed.) The capture and care manual. Wildlife Decision Support Services and the South African Veterinary Foundation, Pretoria: 17-23        [ Links ]

2. Burroughs R E J, McKenzie A A 1993 Handling, care, and loading of immobilized herbivores. In McKenzie A A (ed.) The capture and care manual. Wildlife Decision Support Services and the South African Veterinary Foundation, Pretoria: 184-191        [ Links ]

3. BurroughsREJ,Morkel P, Kock M D, Hofmeyr M, Meltzer D 2006 Chemical immobilization - individual species requirements. In Kock M D, Meltzer D, Burroughs R E J (eds) Chemical and physical restraint of wild animals. International Wildlife Veterinary Services (Africa), Greyton, South Africa: 116-211        [ Links ]

4. Cheney C S, Hattingh J 1987 Effects of chemical immobilization on the blood composition of impala. Journal of the South African Veterinary Association 59: 13-18        [ Links ]

5. Clark W G, Lipton J M 1985 Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents: II. Neuroscience and Biobehavioral Reviews 9: 479-552        [ Links ]

6. Cooper D V, Grobler D, Bush M, Jessup D, Lance W 2005 Anaesthesia of nyala (Tragelaphus angasi) with a combination of thiafentanil (A3080), medetomidine and ketamine. Journal ofthe South African Veterinary Association 76: 18-21        [ Links ]

7. Cremer J E, Bligh J 1969 Body-temperature and response to drugs. British Medical Bulletin 25: 299-305        [ Links ]

8. Fick L, Matthee A, Mitchell D, Fuller A 2006 The effect of boma-housing and long-acting tranquillizers on body temperature, physical activity and food intake of blue wildebeest (Connochaetes taurinus). Journal of Thermal Biology 31: 159-167        [ Links ]

9. Flacke J W 1992 Alpha 2-adrenergic agonists in cardiovascular anesthesia. Journal of Cardiothoracic and Vascular Anesthesia 6: 344-359        [ Links ]

10. Geller E B, Rowan C H, Aider M W 1986 Body temperature effects of opioids in rats: intracerebroventricular administration. Pharmacology Biochemistry and Behaviour 24: 1761-1765        [ Links ]

11. Grobler D, Bush M, Jessup D 2001 Anaesthesia of gemsbok (Oryxgazella) with a combination of A3080, medetomidine and ketamine. Journal of the South African Veterinary Association 72: 81-83        [ Links ]

12. Haskins S C 1995 Thermoregulation, hypothermia, hyperthermia. In Ettinger S J, Feldman E C (eds) Veterinary internal medicine, Vol. 1. W B Saunders, Philadelphia: 26-30        [ Links ]

13. Hofmeyr J M, Louw G N, du Preez J S 1973 Incipient capture myopathy as revealed by blood chemistry of chased zebra. Madoqua 7: 45-50        [ Links ]

14. Jalanka H H, Roeken B O 1990 The use of medetomidine, medetomidine-ketamine combinations, and atipamezole in non-domestic mammals: a review. Journal of Zoo and Wildlife Medicine 21: 259-282        [ Links ]

15. Janssen D L, Swan G E, Raath J P, McJames S W, Allen J L, de Vos V, Williams K E, Anderson J M, Stanley T H 1993 Immobilization and physiologic effects of the narcotic A-3080 in impala (Aepyceros melampus). Journal ofZoo and Wildlife Medicine 24: 11-18        [ Links ]

16. Jessen C 2001 Temperature regulation in humans and other mammals. Springer-Verlag, Berlin        [ Links ]

17. Jessen C, Laburn H P, Knight M H, Kuhnen G, Goelst K, Mitchell D 1994 Blood and brain temperatures of free-ranging black wildebeest in their natural environment. American Journal of Physiology - Regulatory Integrative and Comparative Physiology 267: R1528-R1536        [ Links ]

18. Knox C M, Hattingh J 1992 Physiological response of boma-confined impala to repeated capture. South African Journal of Wildlife Research 22: 1-6        [ Links ]

19. Maskrey M, Vogt M, Bligh J 1970 Central effects of clonidine (2-(2,6-dichlorophenyl-amino)-2-imidazoline hydrochloride, St 155) upon thermoregulation in the sheep and goat. European Journal of Pharmacology 12: 297-302        [ Links ]

20. Meltzer D, Kock N 2006 Applied pharmacology. In Kock M D, Meltzer D, Burroughs R E J (eds) Chemical and physical restraint of wild animals. International Wildlife Veterinary Services (Africa), Greyton, South Africa: 43-67        [ Links ]

21. Meltzer D, Kock N 2006 Stress and capture related death. In Kock M D, Meltzer D, Burroughs R (eds) Chemical and physical restraint ofwild animals. International Wildlife Veterinary Services (Africa), Greyton: 68-76        [ Links ]

22. Meyer L C R, Fick L, Matthee A, Mitchell D, Fuller A 2008 Hyperthermia in captured impala (Aepyceros melampus): a fright not flight response. Journal of Wildlife Diseases 44: 404-416        [ Links ]

23. Mitchell G, Heffron J J A 1980 Porcine stress syndromes: a mitochondrial defect? South African Journal of Science 76: 546-551        [ Links ]

24. Montané J, Marco I, López-Olvera J, Perpiñán D, Manteca X, Lavin S 2003 Effects of acepromazine on capture stress in roe deer (Capreolus capreolus). Journal of Wildlife Diseases 39: 375-386        [ Links ]

25. Montané J, Marco I, López-Olvera J, Rossi L, Manteca X, Lavin S 2007 Effects of acepromazine on the signs of capture stress in free-ranging roe deer (Capreolus capreolus). Veterinary Record 160: 730-738        [ Links ]

26. Morton D J, Anderson E, Foggin C M, Cock M D, Tiran E P 1995 Plasma cortisol as an indicator of stress due to capture and translocation in wildlife species. Veterinary Record 136: 50-63        [ Links ]

27. Nakamori T, Morimoto A, Morimoto K, Tan N, Mukarakami N 1993 Effects of a- and ß-adrenergic antagonists on rise in body temperature induced by psychological stress in rats. American Journal of Physiology -Regulatory Integrative and Comparative Physiology 33: R156-R161        [ Links ]

28. Oka T, Oka K, Hori T 2001 Mechanisms and mediators of psychological stress-induced rise in core temperature. Psychosomatic Medicine 63: 467-486        [ Links ]

29. Olivier B, Zethof T, Pattij T, van Boogaert M, van Oorschot R, Leahy C, Oosting R, Bouwknecht A, Veening J, van der Gugten J, Groenink L 2003 Stress-induced hyperthermia and anxiety: pharmacological validation. European Journal of Pharmacology 463: 117-132        [ Links ]

30. Roquebert J, Delgoulet C 1988 Cardiovascular effects of etorphine in rats. Journal of Autonomic Pharmacology 8: 39-43        [ Links ]

31. Rosow C E, Miller J M, Pelikan E W, Cochin J 1980 Opiates and thermoregulation in mice. Journal of Pharmacology and Experimental Therapeutics 213: 273-283        [ Links ]

32. Swan G E 1993 Drugs used for the immobilization, capture, and translocation of wild animals. In McKenzie A A (ed.) The capture and care manual. Wildlife Decision Support Services and the South African Veterinary Foundation, Pretoria: 17-23        [ Links ]

 

 

Received: November 2007
Accepted: June 2008

 

 

* Author for correspondence. E-mail: leith.meyer@wits.ac.za

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