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Journal of the South African Veterinary Association

On-line version ISSN 2224-9435
Print version ISSN 1019-9128

J. S. Afr. Vet. Assoc. vol.79 n.1 Pretoria  2008

 

CLINICAL COMMUNICATION KLINIESE MEDEDELING

 

Acute lead intoxication in a pregnant mare

 

 

K KrugerI; M N SaulezI; J A NeserII; K SolbergIII

IDepartment of Companion Animal Clinical Studies, Equine Internal Medicine, Faculty of Veterinary Science, Private Bag X04, Onderstepoort, 0110 South Africa
IIDepartment of Paraclinical Sciences, Faculty of Veterinary Science, Private Bag X04, Onderstepoort, 0110 South Africa
IIIFinal Year Veterinary Science Student, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa

 

 


ABSTRACT

Lead (Pb) intoxication in horses is usually a chronic phenomenon with clinical signs associated with central nervous dysfunction. This report gives details of a case of acute Pb intoxication in a 9-year-old American Saddlebred mare with severe, progressive and ultimately fatal neurological deterioration. During the 4 days of hospitalisation, clinical signs progressed from intermittent headshaking and depression to severe, continuous, uncontrollable manic behaviour. At autopsy, three grey-coloured, hard metal particles were present in the gastrointestinal tract and subsequently found to contain 2614 ppm Pb. Lead concentrations in the brain, liver, stomach and kidney were 29, 4, 6 and 2 ppm wet weight, respectively.

Key words: cerebral dysfunction, equine, lead intoxication


 

 

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REFERENCES

1. Aguilera-Tegero E, Mayer-Valor R, Fernandez-Gomez M, Gomez-Villamandos J C, Cano-Exposito T 1996 Lead poisoning, laryngeal paralysis and pulmonaryhemorrhage in two horses. Equine Practice 18: 16-20        [ Links ]

2. Arnson A L 1972 Lead poisoning in cattle and horses following long-term exposure to lead. American Journal of Veterinary Research 33: 627-629        [ Links ]

3. Barton J C, Conrad M E, Harisson L, Nuby S 1978 Effects of calcium on the absorption and retention of lead. Journal of Laboratory and Clinical Medicine 91: 366-376        [ Links ]

4. Buck W B 1970 Lead and organic pesticide poisonings in cattle. Journal of the American Veterinary Medical Association 156: 1468-1472        [ Links ]

5. Burrows G E 1982 Lead poisoning in the horse. Equine Practice 4: 30-36        [ Links ]

6. Burrows G E, Borchard R E 1982 Experimental lead toxicosis in ponies: comparison of the effects of smelter effluent-contaminated hay and lead acetate. American Journal of Veterinary Research 43: 2129-2133        [ Links ]

7. Burrows G E, Sharp J W, Root R G 1981 A survey of blood lead concentrations in the north Idaho lead/silver belt area. Veterinary and Human Toxicology 23: 328-330        [ Links ]

8. Casteel S W 2001 Metal toxicosis in horses. Veterinary Clinics of North America: Equine Practice 17: 517-527        [ Links ]

9. Dollahite W, Younger R L, Crookshank H R, Jones L P Petersen H D 1978 Chronic lead poisoning in horses. American Journal of Veterinary Research 39: 961-964        [ Links ]

10. Egan D A, O'Cuill T 1970 Cumulative lead poisoning in horses in a mining area contaminated with galena. The Veterinary Record 86: 736-738        [ Links ]

11. George L W 1996 Diseases of the nervous system. In Smith B P (ed.) Large animal internal medicine (2nd edn). Mosby, Missouri: 1001-1175        [ Links ]

12. Gwaltney-Brant S 2004: Lead. In Plumblee K H (ed.), Clinical veterinary toxicology. Mosby, Missouri: 204-210        [ Links ]

13. Hammand P B, Arnson A L 1964 Lead poisoning in cattle and horses. Annals of the New York Academy of Sciences 3: 595-611        [ Links ]

14. Hatch R C 1982 Poisons causing nervous stimulation or depression. In Booth N H, McDonald L E (eds), Veterinary pharmacology and therapeutics (5th edn). Iowa State University Press, Ames: 1005-1012        [ Links ]

15. Knight H D, Burau R G 1973 Chronic lead poisoning in horses. Journal of the American Veterinary Medical Association 162: 781-786        [ Links ]

16. Maxie M G, Youssef S 2007 Nervous system. In Maxie M G (ed.) Jubb, Kennedy, and Palmer's pathology of domestic animals (5th edn). Elsevier, Toronto: 281-457        [ Links ]

17. Nielsen S W 1971 Environmental pollutants pathogenic to animals. Journal of the American Veterinary Medical Association 159: 1103-1107        [ Links ]

18. Priester W A, Hayes H M 1974 Lead poisoning in cattle, horses, cats and dogs reported by 11 colleges of veterinary medicine in the United States and Canada from July, 1968, through June, 1972. American Journal of Veterinary Research 35: 567-569        [ Links ]

19. Puls R 1994 Toxic levels of lead in the brain and liver of horses (2 nd edn.) In Mineral levels in animal health. Sherpa International, Clearbrook: 153        [ Links ]

20. Schmitz D G 2004 Toxicologic problems. In Reed S M, Bayly W M, Sellon D C (eds), Equine internal medicine (2nd edn). Elsevier, Missouri: 1477-1479        [ Links ]

21. Willoughby R A 1971 Normal blood and milklead values. Canadian Veterinary Journal 12: 165-171        [ Links ]

 

 

Received: October 2007
Accepted: February 2008

 

 

* Author for correspondence: E-mail: montague.saulez@up.ac.za

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