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Journal of the South African Veterinary Association

On-line version ISSN 2224-9435

J. S. Afr. Vet. Assoc. vol.79 n.1 Cape Town  2008

 

REVIEW ARTICLE OORSIGARTIKEL

 

Epidemiology, disease and control of infections in ruminants by herpesviruses - An overview

 

 

J R Patel; S Didlick

JAS Biologicals Limited, The Centre for Veterinary Science, Madingley Road, Cambridge, CB3 OES, UK

 

 


ABSTRACT

There are at least 16 recognised herpesviruses that naturally infect cattle, sheep, goats and various species of deer and antelopes. Six of the viruses are recognised as distinct alphaherpesviruses and 9 as gammaherpesviruses. Buffalo herpesvirus (BflHV) and ovine herpesvirus-1 (OvHV-1) remain officially unclassified. The prevalence of ruminant herpesviruses varies from worldwide to geographically restricted in distribution. Viruses in both subfamilies Alphaherpesvirinae and Gammaherpesvirinae cause mild to moderate and severe disease in respective natural or secondary ruminant hosts. Accordingly, the economic and ecological impact of the viruses is also variable. The molecular characteristics of some members have been investigated in detail. This has led to the identification of virulence-associated genes and construction of deletion mutants and recombinant viruses. Some of the latter have been developed as commercial vaccines. This paper aims to give an overview of the epidemiology and pathogenesis of infection by these viruses, immuno-prophylaxis and mechanisms of recovery from infection. Since there are 128 ruminant species in the family Bovidae, it is likely that some herpesviruses remain undiscovered. We conclude that currently known ruminant alphaherpesviruses occur only in their natural hosts and do not cross stably into other ruminant species. By contrast, gammaherpesviruses have a much broader host range as evidenced by the fact that antibodies reactive to alcelaphine herpesvirus type 1 have been detected in 4 subfamilies in the family Bovidae, namely Alcelaphinae, Hippotraginae, Ovibovinae and Caprinae. New gammaherpesviruses within these subfamilies are likely to be discovered in the future.

Key words: disease and immunoprophylaxis, epidemiology, herpesviruses, pathogenesis, ruminant


 

 

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REFERENCES

1. Baxter S I, Pow I, Bridgen A, Reid H W 1993 PCR detection of the sheep-associated agent of malignant catarrhal fever. Archives of Virology 132: 145-159        [ Links ]

2. Babiuk L A, Van Drunen Little-van den Hurk S, Tikoo S K 1996 Immunology of bovine herpesvirus infection. Veterinary Microbiology 53: 31-42        [ Links ]

3. Berrios P E, McKercher D G 1975 Characterization of a caprine herpesvirus. American Journal of Veterinary Research 36: 1755-1762        [ Links ]

4. Berrios P E, McKercher D G, Knight H D 1975 Pathogenicity of a caprine herpes-virus. American Journal of Veterinary Research 36: 1763-1769        [ Links ]

5. Brake F, Studdert M 1985 Molecular epidemiology and pathogenesis of ruminant herpesviruses including bovine, buffalo and caprine herpesvirus 1 and bovine encephalitis herpesvirus. Australian Veterinary Journal 62: 331-334        [ Links ]

6. Bratanich A C, Sardi S I, Smitstaart E N, Schudel A A 1991 Comparative studies of BHV-1 variants by in vivo and in vitro tests. Journal of Veterinary Medicine B 38: 41-48        [ Links ]

7. Bridgen A, Reid H W 1991 Derivation of a DNA clone corresponding to the viral agent of sheep-associated malignant catarrhal fever. Research in Veterinary Science 50:38-44        [ Links ]

8. Bridgen A, Munro R, Reid H W 1992 The detection of Alcelaphine Herpesvirus-1 DNA by in situ hybridisation of tissues from rabbits affected with malignant catarrhal fever. Journal of Comparative Pathology 106: 351-359        [ Links ]

9. Cavirani S, Donofrio G, Foni E, Galvani G, Flammini C F 2000 Bovine herpesvirus type 4 (BHV-4) isolated from chronic diseases of cattle. Proceedings of the 5th International Congress of Veterinary Virology, Brescia, Italy, 27-30 August 2000: 87-88        [ Links ]

10. Chow T L, Davies R W 1964 The susceptibility of mule deer to infectious bovine rhino-tracheitis. American Journal of Veterinary Research 25: 518-519        [ Links ]

11. Chowdhury S I 1996 Construction and characterisation of an attenuated bovine herpesvirus type 1 (BHV-1) recombinant virus. Veterinary Microbiology 52: 13-23        [ Links ]

12. Clark K A, Robinson R M, Marburger R G, Jones, L P, Orchard J H 1970 Malignant catarrhal fever in Texan cervids. Journal of Wildlife Diseases 6: 276-283        [ Links ]

13. Collings D F, Gibbs E P J, Stafford L P 1972 Concurrent respiratory and genital disease associated with infectious bovine rhino-tracheitis/infectious pustularvulvo vaginitis (IBR/IPV) virus in a diary herd in United Kingdom. Veterinary Record 91: 214-219        [ Links ]

14. Denholm L J, Westbury H A 1982 Malignant catarrhal fever in farmed rusa deer (Cervus timorensis) 1. Clinico-pathological observations. Australian Veterinary Journal 58:81-87        [ Links ]

15. Dubuisson J, Thiry E, Bublot M, Bressem M F, Van Coignoul F, Pastoret P-P 1989 Experimental infection of bulls with a genital isolate of bovine herpesvirus-4 and reactivation of latent virus with dexamethasone. Veterinary Microbiology 21: 97-114        [ Links ]

16. Engels M, Loepfe E, Wild P, Schraner E, Wyler R 1987 The genome of caprine herpes virus 1: genome structure and relatedness to bovine herpes virus 1. Journal of General Virology 68: 2019-2023        [ Links ]

17. Engels M, Palatini M, Metzler A E, Probst U, Kihm U, Ackermann M 1992 Interactions of bovine and caprine herpesviruses with the natural and the foreign hosts. Veterinary Microbiology 33: 69-78        [ Links ]

18. Engels M, Ackermann M 1996 Pathogenesis of ruminant herpes virus infections. Veterinary Microbiology 53: 3-15        [ Links ]

19. Ek-Kommonen C, Veijalainen P, Rantala M, Neuvonen E 1986 Neutralising antibodies to bovine herpes virus 1 from a reindeer (Rangifer tarandus). Acta Veterinaria Scandinavia 27: 299-301        [ Links ]

20. French E L 1962 A specific virus encephalitis in calves: isolation and characterization of the causal agent. Australian Veterinary Journal 38: 216-221        [ Links ]

21. Gibbs E P J, Rweyemamu M M 1977 Bovine herpes viruses. Part 1. Bovine herpesvirus 1. Veterinary Bulletin 47: 317-343        [ Links ]

22. Hatkin J 1980 Endemic malignant catarrhal fever at the San Diego wild animal park. Journal of Wildlife Diseases 16: 439-443        [ Links ]

23. Herring A, Reid H, Inglis N, Pow I 1989 Immunoblotting analysis of the reaction of wildebeest, sheep and cattle sera with the structural antigens of alcelaphine herpes-virus-1 (malignant catarrhal fever virus). Veterinary Microbiology 19: 205-215        [ Links ]

24. Heuschele W P 1988 Malignant catarrhal fever: a review of a serious disease hazard for exotic and domestic ruminants. Zoologische Garten 58: 123-133        [ Links ]

25. Hussy D, Muller-Doblies U, Stauber N, Braun U, Ackermann M 2000 Diagnosis and pathogenesis of the putative ovine herpes virus 2, agent of malignant catarrhal fever. Proceedings of the 5th International Congress of Veterinary Virology, Brescia, Italy, 27-30 August 2000: 105-106.         [ Links ]

26. Inglis D M, Bowie J M, Allan M J, Nettleton P F 1983 Ocular disease in red deer calves associated with a herpes virus infection. Veterinary Record 113: 182-183        [ Links ]

27. Kahrs R F, Smith R S 1965 Infectious bovine rhinotracheitis, pustular vulvovaginitis and abortion in a New York dairy herd. Journal of the American Veterinary Medical Association 146: 217-220        [ Links ]

28. Kendrick J W, York C J, McKercher D G 1956 A controlled field trial of a vaccine for infectious bovine rhinotracheitis. Proceedings of the United States Livestock Sanitory Association 60: 155-158.         [ Links ]

29. Keuser V, Meyer G, Robert B, Collard F, Thiry E 2000 Production and characterisation of monoclonal antibodies directed against caprine herpes virus type1. Proceedings of the 5th International Congress of Veterinary Virology, Brescia, Italy, 27-30 August 2000: 95-96.         [ Links ]

30. Kit S, Qavi H, Gaines J D, Billinglsey P McConnell S 1985 Thymidine kinase negative bovine herpesvirus type 1 mutant is stable and highly attenuated in calves. Archives ofVirology 86: 53-83        [ Links ]

31. Kit S 1988 Genetically engineered pseudo-rabies and infectious bovine rhinotracheitis virus vaccines. In Lasky L (ed.) Technological advances in vaccine development. UCLA Symposia on molecular and cellular biology. Alan R Liss, New York: 183-195        [ Links ]

32. Li H, Shen D T, Knowles D P, Gorham J R, Crawford T B 1994 Competitive inhibition enzyme-linked immunosorbet assay for antibody in sheep and other ruminants to a conserved epitope of malignant catarrhal fever virus. Journal of Clinical Microbiology 32: 1674-1679        [ Links ]

33. Li H, Dyer N, Keller J, Crawford T B 2000 Newly recognized herpesvirus causing malignant catarrhal fever virus in white-tailed deer (Odocoileus virginianus). Journal of Clinical Microbiology 38: 1313-1318        [ Links ]

34. Li H, Keller J, Knowles D P, Crawford T B 2001 Recognition of another member of the malignant catarrhal fever virus group; an epidemic gammaherpesvirus in domestic goats. Journal of General Virology 82: 227-232        [ Links ]

35. Li H, McGuire T C, Muller-Doblies U, Crawford T B 2001 A simpler, more sensitive competitive inhibition enzyme-linked immunosorbent assay for detection of antibody to malignant catarrhal fever viruses. Journal of Veterinary Diagnostic Investigations 13: 361-364        [ Links ]

36. Loken T, Aleksandersen M, Reid H, Pow I 1998 Malignant catarrhal fever caused by ovine herpesvirus 2 in pigs in Norway. Veterinary Record 143: 464-467        [ Links ]

37. Lyaku J R S, Nettleton P F, Marsden H 1992 A comparison of serological relationships among five ruminant alphaherpesviruses by ELISA. Archives of Virology 124: 333-341        [ Links ]

38. Madin S H, York C J, Mckercher D G 1956 Isolation of infectious bovine rhinotracheitis virus. Science 124: 721-722        [ Links ]

39. Martin W B 1990 Bovine mamalitis virus. In Dinter Z, Morein B M (eds) Virus infections of ruminants. Elsevier Science Publishers, Amsterdam: 109-116        [ Links ]

40. McAllum H J F, Mavor N M, Hemmingsen P 1982 A malignant catarrhal fever-like disease in red deer (Cervus elaphus)inNew Zealand. New Zealand Veterinary Journal 30: 99-101.         [ Links ]

41. Mckercher D G 1963 Studies of the etiologic agents of infectious bovine rhinotracheitis and Bläschenausschlag (coital vesicular exanthema). American Journal of Veterinary Research 24: 501-509.         [ Links ]

42. McKercher D G, Bibrack B, Richards W P C 1970 Effects of the infectious bovine rhinotracheitis virus on the central nervous system of cattle. Journal of the American Veterinary Medical Association 156:1460-1467        [ Links ]

43. Meyer G, Lemaire M, Ros C, Belak K, Gabriel A, Cassart D, Coignoul F, Belak S, Thiry E 2000. Comparative pathogenesis of acute and latent infections of calves with bovine herpes virus types 1 and 5. Proceedings of the 5th International Congress of Veterinary Virology, Brescia, Italy, 27-30 August 2000: 75-76.         [ Links ]

44. Mohanty S B, Lillie M G, Corselius N P Beck J D 1972 Natural infection with infectious bovine rhinotracheitis virus in goats. Journal of American Veterinary Medical Association 160: 879-880        [ Links ]

45. Mohanty S B, Hyllseth B 1990 Other herpesviruses. In Dinter Z, Morein B (eds), Virus infections of ruminants. Elsevier Science Publishers, Amsterdam: 151-160        [ Links ]

46. Nash A A 1997 Immunological and virological determinants in gammaherpesvirus infections. Proceedings of the 4th International Congress of Veterinary Virology, Virus Survival and Vaccination, Edinburgh, Scotland, 24-27 August 1997: 13        [ Links ]

47. Nettleton P F, Sinclair J A, Herring J A, Inglis D N, Fletcher T J, Ross H M, Bonniwell M A 1986 Prevalence of herpesvirus infection in British red deer and investigation of further disease outbreaks. The Veterinary Record 118: 267-270        [ Links ]

48. Nettleton P F, Thiry E, Reid H, Pastoret P-P 1988 Herpesvirus infections in Cervidae. Scientific and Technical Review (International Office of Epizootics) 7: 977-988.         [ Links ]

49. Nettleton P F, Ek-Kommonen C, Tanskanen R, Reid H W, Sinclair J A, Herring J.A 1988 Studies on the epidemiology and pathogenesis of alphaherpes viruses form red deer (Cervus elaphus) and reindeer (Rangifer tarandus). In Reid H W (ed.) The management and health of farmed deer. Kluwer Academic Publishers, Boston: 143-148.         [ Links ]

50. Nixon P, Edwards S, White H 1988 Serological comparisons of antigenically related herpes viruses in cattle, red deer and goats. Veterinary Research Communications 12: 355-362        [ Links ]

51. O'Toole D, Li H, Muller D, Williams W R, Crawford T B 1997 Chronic and recovered cases of sheep-associated malignant catarrhal fever in cattle. Veterinary Record 140:519-524        [ Links ]

52. O'Toole D, Taus N S, Montgomery D l, Oaks J L, Crawford T B, Li H 2007 Intra-nasal inoculation of American bison (Bison bison) with ovine herpesvirus-2 (OvHV-2) reliably reproduces malignant catarrhal fever. -Veterinary Pathology 44: 655-662        [ Links ]

53. Papanstasopoulou M, Koptopoulos G, Lekkas S, Papadopoulos O, Ludwig H 1991 An experimental study on the pathogenicity of the caprine herpesvirus type 1 (CHV-1). Comparative Immunology and Microbiology ofInfectious Diseases 14: 47-53        [ Links ]

54. Patel J R, Edington N 1980 The detection of the herpesvirus of bovine malignant catarrhal fever in rabbit lymphocytes in vivo and in vitro. Journal of General Virology 48: 437-444        [ Links ]

55. Patel J R, Edington N 1982 Immune complexes associated with infection of cattle by the herpesvirus of malignant catarrhal fever. Veterinary Microbiology 7: 335-341        [ Links ]

56. Patel J R 2005 Characteristics of live bovine herpesvirus-1 vaccines. The Veterinary Journal 169: 404-416        [ Links ]

57. Patel J R 2005 Relative efficacy of inactivated bovine herpesvirus-1 (BHV-1) vaccines. Vaccine 23: 4054-4061.         [ Links ]

58. Patel J R, Shilleto R W 2005 Modification of active immunization with live bovine herpesvirus 1 vaccine by passive viral antibody. Vaccine 23: 4023-4028        [ Links ]

59. Piercy S E 1955 Studies of bovine malignant catarrh. VI. Adaptation to rabbits. British Veterinary Journal 111: 484-491        [ Links ]

60. Pierson R E, Storz J, McChesney A E, Thake D 1974 Experimental transmission of malignant catarrhal fever. American Journal of Veterinary Research 35: 523-525        [ Links ]

61. Pinto O, Cirone F, Greco G, Pagnini U, Iovane G 2000 Re-activation of BHV-4 natural infection in Mediterranean buffalo (Bubalus bubalis). Proceedings of the 5th International Congress ofVeterinary Virology, Brescia, Italy, 27-30 August 2000: 91-92        [ Links ]

62. Plowright W, Ferris R D, Scott G R 1960 Blue wildebeest and the aetiological agent of bovine malignant catarrhal fever. Nature 188: 1167-1169.         [ Links ]

63. Plowright W 1981 Herpesviruses of wild ungulates, including malignant catarrhal fever virus. In Davis J W, Karstad L H, Trainer D O (eds) Infectious diseases ofwild mammals (2nd edn). Iowa State University Press, Ames: 126-146.         [ Links ]

64. Plowright W 1986 Malignant catarrhal fever. Scientific and Technical Review (International Office ofEpizootics) 5(4): 897-918        [ Links ]

65. Plowright W 1990 Malignant catarrhal fever virus. In Dinter Z, Morein B M (eds) Virus infections of ruminants. Elsevier Science, Amsterdam, Oxford, New York, Tokyo: 123-150.         [ Links ]

66. Reid H W, Rowe L 1973 The attenuation of a herpesvirus (malignant catarrhal fever virus) isolated from hartebeest (Alcelaphus buselaphus cockei). Research in Veterinary Science 15: 144-156        [ Links ]

67. Reid H W, Buxton D, Corrigal W, Hunter A R, McMartin D A, Rushton B 1979 An outbreak of malignant catarrhal fever in red deer (Cervus elaphus). Veterinary Record 104: 120-123        [ Links ]

68. Reid H W, Buxton D 1984 Malignant catarrhal fever of deer. Proceedings of Royal Society of Edinburgh 82B: 261-293        [ Links ]

69. Reid H W, Nettleton P F, Pow I, Sinclair J 1986 Experimental infection of red deer and cattle with a herpesvirus isolated from red deer. Veterinary Record 118: 156-158        [ Links ]

70. Reid H W, Buxton D, McKelvey W A C, Milne J A, Appleyard W T 1987 Malignant catarrhal fever in Pere David's deer. Veterinary Record 121: 276-277        [ Links ]

71. Reid H W, Buxton D 1989 Malignant catarrhal fever. In Wittman G (ed.), Developments in veterinary virology. Herpesvirus disease of cattle, horses and pigs. Kluwer Academic Publishers Boston, Dordrecht, London: 116-143        [ Links ]

72. Reid H W, Bridgen A 1991 Recovery of a herpesvirus from a roan antelope (Hippotragus equinus). Veterinary Microbiology 28: 269-278        [ Links ]

73. Reid H W, 1992 The biology of fatal herpesvirus infection of deer (malignant catarrhal fever). In Brown R R (ed.) The biology of the deer. Springer-Verlag, New York: 93-100        [ Links ]

74. Rijsewijk F, Kaashoek M, Keil G, Paal H, Ruuls R, van Engelenburg F, van Oirschot J 1994 In vitro and in vivo phenotypes and immunogenic properties of bovine herpesvirus 1 mutants with a deletion in the gC, gG, gI or gE gene. Proceedings of 19th Herpes-virus Workshop, Vancover, Canada 1994: 419        [ Links ]

75. Roizman B, Desrosier R C, Fleckenstein B, Lopez C, Minson A C Studdert M J 1995 In Murphy F A, Fauquet C M, Bishop DHL Ghabrial S A Jarvis A W Martelli G P Mayo M A Summers M D (eds) Virus taxonomy, 6th report of the International Committee on Taxonomy of Viruses. Archives of Virology, supplement 10. Springer-Verlag, Wien, New York: 114-127        [ Links ]

76. Roken B O, Bjorklund N E 1974 Malignant catarrhal fever in an animal reserve. Proceedings of the 12th Nordic Veterinary Congress, Reykjavik, 1974: 197-200        [ Links ]

77. Rossiter P B, Mushi E Z, Plowright W 1977 The development of antibody in rabbit and cattle infected experimentally with an African strain of malignant catarrhal virus. Veterinary Microbiology 2: 57-66        [ Links ]

78. Rovnak J, Quackenbush S L, Reyes R A, Baines J D, Parrish C R, Casey J W 1998 Detection of novel bovine lymphotropic herpesvirus. Journal of Virology 72: 4237-4242        [ Links ]

79. Saito J K, Gribble D H, Berrios P E, Knight H D, McKercher D G 1974 A new herpes-virus isolate from goats: primary report. American Journal of Veterinary Research 35: 847-848        [ Links ]

80. Sanford S E, Little P B, Rapley W A 1977 The gross and histopathological lesions of malignant catarrhal fever in three captive Sika deer (Cervus nippon) in southern Ontario. Journal of Wildlife Diseases 13: 29-32        [ Links ]

81. Schock A, Reid H W 1996 Characterisation of the lymphoproliferation in rabbits experimentally affected with malignant catarrhal fever. Veterinary Microbiology 53: 111-119        [ Links ]

82. Schwyzer M, Ackermann M 1996 Molecular virology of ruminant herpesviruses. Veterinary Microbiology 53: 17-29        [ Links ]

83. Silva A D, Spilki F R, Franco A C, Esteves P A, Hubner S O, Driemeier D, Oliveira A P, Rijsewijk F, Roehe P M 2006 Vaccination with a gE-negative bovine herpesvirus type 1 vaccine confers insufficient protection to a bovine herpesvirus type 5 challenge. Vaccine 24: 3313-3320.         [ Links ]

84. Snowdon W A 1964 Infectious rhino-tracheitis and infectious pustular vulvo-vaginitis in Australian cattle. Australian Veterinary Journal 40: 277-288        [ Links ]

85. Straub O C 1991 BHV-1 infections: relevance and spread in Europe. Comparative immunology. Microbiology and Infectious Diseases 14: 175-186        [ Links ]

86. Straub O C 2002 Advantages and disadvantages of common vaccination programmes for cattle. Kaske M, Scholz H, Hottershinken M. (eds) Recent developments and perspectives in bovine medicine. XXII World Buiatrics Congress Hannover, Germany. Klinik Für Rinderkrankheiten Tierarztliche Hochschule, Hannover, Germany: 86-96        [ Links ]

87. Strube W, Auer S, Block W, Heinen E, Kretzdorn D, Rodenbach C, Schmeer N 1996 A gE deleted infectious bovine herpes-virus 1 control programs. Veterinary Microbiology 53: 181-189        [ Links ]

88. Tarigan S, Webb R F, Kirkland D 1987 Caprine herpesvirus from balanoposthitis. Australian Veterinary Journal 64: 321        [ Links ]

89. Taus N S, Traul D L, Oaks J L, Crawford T B, Lewis G H, Li H 2005 Experimental infection of sheep with ovine herpesvirus 2 via aerosolization of nasal secretions Journal of General Virology 86: 575-579        [ Links ]

90. Taus N S, Oaks J L, Gailbreath K, Traul D L, O'Toole D, Li H 2006 Experimental aerosol infection of cattle (Bos taurus) with ovine herpesvirus 2 using nasal secretions from infected sheep. Veterinary Microbiology 116: 29-36        [ Links ]

91. Tempesta M, Pratelli A, Buonavoglia D, Camero M, De Capralis D, Gyseco G 1989 A study on the pathogenicity of a strain of caprine herpes virus 1. Comparative Immunology and Microbiology ofInfectious Diseases 22: 137-143        [ Links ]

92. Tempesta M, Martella V, Gycco G, Pratelli A, Camero M, Buonavoglia C 2000 Preliminary report on the immunization of goats for caprine herpesvirus 1 infection. Proceedings of the 5th International Congress of Veterinary Virology, Brescia, Italy, 27-30 August 2000: 97-98        [ Links ]

93. Thiry E, Bublot J, Dubuisson J, Pastoret P-P 1989 Bovine herpesvirus-4 infections of cattle. In Wittman G (ed.) Herpesvirus diseases of cattle, horses and pigs. Kluwer Academic Publishers, Boston, Dordrecht, London: 96-115        [ Links ]

94. Thiry E, Bulbot J, Dubusson J, van Bressem M F, Lequarre P, Lomonte P, Vander-plasschen A, Pastoret P-P 1992 Molecular biology of bovine herpesvirus type 4. Veterinary Microbiology 33: 79-92        [ Links ]

95. Todd W J, Storz J 1983 Morphogenesis of a cytomegalovirus from an American bison affected with malignant catarrhal fever. Journal ofGeneral Virology 64: 1025-1030        [ Links ]

96. Tong E H, Senior M, Halman C R E 1961 An outbreak of malignant catarrh among the Père David's deer. Proceedings of Zoological Society of London 1961 136: 477-483        [ Links ]

97. van der Lugt J J, Randles J L 1993 Systemic herpesvirus infection in neonatal goats. Journal of South African Veterinary Association 64: 169-171        [ Links ]

98. van Engelenburg F, Kaashoek M, Rijsewijk F, van den Burg L, Gielkens A, Oirschot, J T 1994 A glycoprotein E deletion mutant of bovine herpesvirus 1 is avirulent in calves. Journal of General Virology 75: 2311-2318.         [ Links ]

99. van Oirschot J T, Kaashoek M J, Rijsewijk F A M 1996 Advances in the development and evaluation of bovine herpesvirus 1 vaccines. Veterinary Microbiology 53: 43-54.         [ Links ]

100. Wellenberg G J, Mars M H, van Oirschot J T 2000 Antibodies against bovine herpes virus (BHV) 5 cross-react in a BHV1 glyco-protein B ELISA and in 1 of two glyco-protein E ELISAs. Proceedings of the 5th International Congress ofVeterinary Virology, Brescia, Italy, 27-30 August 2000: 93-94        [ Links ]

101. Whitenack D L, Castro A E, Kocan A A 1981 Experimental malignant catarrhal fever (African form) in white-tailed deer. Journal of Wildlife Diseases 17: 443-451        [ Links ]

102. Wiyono A, Baxter S I, Saepullon M, Damayanti R, Daniels P, Reid H W 1994 PCR detection of ovine herpesvirus 2 DNA in Indonesian ruminants - normal sheep and clinical cases of malignant catarrhal fever. Veterinary Microbiology 42: 45-52        [ Links ]

103. Wyand D S, Helmboldt C F, Nielson S W 1971 Malignant catarrhal fever in white-tailed deer. Journal of American Veterinary Medical Association 159: 605-610        [ Links ]

 

 

Received: May 2007
Accepted: March 2008

 

 

* E-mail: jasltd@aol.com

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