RESEARCH ARTICLE

 

Synthesis of novel thieno[3,2-b]quinolines and thieno[3,2-d][1,3]thiazoles

 

 

Yazid Datoussaid^{I, II, *}; Gilbert Kirsch^II; Adil A. Othman^I; Ismail Abdillahi^II

^ILaboratory of Bimolecular and Organic Synthesis, Chemistry Department, Faculty of Science, University of Sciences and Technology-Mohamed Boudiaf-Oran-USTO, MB-, P.O.B. 1505 El-M'naouer, 31000, Oran Algeria
^IILaboratoire d'Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, FR CNRS 2843, 1 Boulevard Arago, 57070 METZ, France

 

 

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ABSTRACT

New heterocyclic 2-Aryl-9-chloro-5,6,7,8-tetrahydrothieno[3,2-b]quinoline derivatives [Aryl-CTTQ] ( 2a-e ) and 5-arylthieno[3,2-d][1,3]thiazol-2-amine derivatives[Aryl-TZA] ( 6a-e )were achieved in good yields starting from 5-aryl-3-aminothiophene-2-carboxylic acid ( 1a-c ).

Keywords: 5-Aryl-3-aminothiophene-2-carboxylic acid, thieno[3,2-b]quinoline, thiourea, thieno [3,2-d][1,3]thiazole

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Received 20 April 2012
Revised 13 August 2012
Accepted 16 August 2012

 

 

* To whom correspondence should be addressed. E-mail:datou_yazid@yahoo.fr