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South African Journal of Chemistry
versión On-line ISSN 1996-840X
versión impresa ISSN 0379-4350
S.Afr.j.chem. (Online) vol.65 Durban 2012
RESEARCH ARTICLE
Rapid synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinones using boric acid or sodium dihydrogen phosphate under solvent-free conditions
Zahed Karimi-Jaberi*; Leila Zarei
Department of Chemistry, Firoozabad Branch, Islamic Azad University, P.O. Box 74715-117 Firoozabad, Fars, Iran
ABSTRACT
Two efficient and convenient methods have been described for synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinone derivatives by one-pot condensation of 2-anthranilamide with aldehydes or ketones in the presence of a catalytic amount of boric acid or sodium dihydrogen phosphate under solvent-free conditions. The attractive features of these processes are short reaction times, easy isolation of products, excellent yields and an environmental friendly procedure
Keywords: Dihydroquinazolinones, boric acid, sodium dihydrogen phosphate, 2-anthranilamide, solvent-free synthesis
Full text available only in PDF format.
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Received 24 November 2011
Revised 18 January 2012
Accepted 7 February 2012
* To whom correspondence should be addressed. E-mail: z.karimi@iauf.ac.ir