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South African Journal of Chemistry

versión On-line ISSN 1996-840X
versión impresa ISSN 0379-4350

S.Afr.j.chem. (Online) vol.64  Durban  2011

 

SHORT COMMUNICATION

 

Microwave irradiation versus conventional heating in the synthesis of N-methyl-2-pyrrolidone catalyzed by highly active copper powder

 

 

N.D. Jumbam*; L. Phuthuma; R. Ndebvu; T. Ngarivhume

Department of Chemistry and Chemical Technology, Walter Sisulu University, Private BagX1, WSU, 5117 Mthatha, Eastern Cape, South Africa

 

 


ABSTRACT

A convenient one-pot synthesis of N-methyl-2-pyrrolidone is achieved either by conventional heating or microwave irradiation. The intermediate N-methyl-4-hydroxybutyramide formed from the exothermic reaction of 7-butyrolactone with aqueous methylamine undergoes an intramolecular condensation reaction catalyzed by highly active copper powder to form the pyrrolidone in good yield.

Keywords: Copper catalyst, N-methyl-2-pyrrolidone, methylamine, ϒ-butyrolactone, one-pot synthesis, microwave irradiation


 

 

Full text available only in pdf format.

 

Acknowledgements

We are grateful to the Directorate of Research Development at Walter Sisulu University for financial support.

 

References

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Submitted 7 March 2011
Revised 3 April 2011
Accepted 4 May 2011

 

 

Submitted by invitation to celebrate 2011 - the 'International Year of Chemistry
* To whom correspondence should be addressed. E-mail: njumbam@wsu.ac.za

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