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South African Journal of Chemistry
versión On-line ISSN 1996-840X
versión impresa ISSN 0379-4350
S.Afr.j.chem. (Online) vol.64 Durban 2011
SHORT COMMUNICTION
Synthesis of 9H-indeno [1, 2-b] pyrazine and 11H-indeno [1, 2-b] quinoxaline derivatives in one-step reaction from 2-bromo-4-chloro-1-indanone
S. JasouriI, II; J. KhalafyI, *; M. BadaliII ; R.H. PragerIII
IDepartment of Chemistry, Urmia University, Urmia 57154, Iran
IIDaana Pharmaceutical Co., P.O. Box 5181, Tabriz 51575, Iran
IIISchool of Chemical and Physical Sciences, Flinders University, G.P.O. Box 2100, Adelaide, Australia 5001
ABSTRACT
The reaction of 2-bromo-4-chloro-1-indanone with 2,3-diaminomaleonitrile, benzene-1,2-diamine and 4-methylbenzene-1,2-diamine in glacial acetic acid gave 8-chloro-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 1-chloro-11H-indeno[1,2-b]quinoxa-line and 1-chloro-7-methyl-11H-indeno[1,2-b]quinoxaline, respectively, in good yield.
Keywords: 2-bromo-4-chloro-1-indanone, diaminopyridine, indeno[1,2-b]quinoxaline, indeno[1,2-b]pyrazine, debromination
Full text available only in pdf format.
Acknowledgements
We gratefully acknowledge the University of Urmia and Daana Pharmaceutical Co. for providing a fellowship for the present work.
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Received 22 January 2011
Revised 21 April 2011
Accepted 4 May 2011
* To whom correspondence should be addressed. E-mail: j.khalafi@mail.urmia.ac.ir; jkhalafi@yahoo.com