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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350

S.Afr.j.chem. (Online) vol.63  Durban  2010




Ph3P catalyzed synthesis of alkyl 2-(4-oxopyridin-1(4H)-yl)acrylates by nucleophilic addition to alkyl propiolates



Bita MohtatI, * ; Setareh AzimzadehI; Hoorieh DjahanianiII; Leila PirhadiI

IChemistry Department, Islamic Azad University, Karaj Branch, Karaj, Iran
IIChemistry Department, Islamic Azad University, East Tehran Branch, Qiamdasht, Tehran, Iran




4-Hydroxypyridine undergoes a smooth reaction with alkyl propiolates in the presence of triphenylphosphine to produce α and β-substituted alkyl acrylate products. When the reaction was performed with 4-hydroxyquinoline only α-substituted alkyl acrylates were obtained.

Keywords: 4-hydroxypyridine, 4-hydroxyquinoline, alkyl acrylates, alkyl propiolates, triphenylphosphine



Full text available only in PDF format.




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Received 7 October
Revised 9 November
Accepted 18 November 2010



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