RESEARCH ARTICLE

 

Alum an efficient catalyst for Erlenmeyer synthesis

 

 

Balaji R. Madje^{I, *}; Milind B. Ubale^I; Jagdish V. Bharad^I; Murlidhar S. Shingare^II

^IDepartment of Chemistry, Vasantrao Naik Mahavidyalaya, Aurangabad-431 003 (M.S.) India
^IIDepartment of Chemistry, Dr. Babasaheb Ambedkar Martahwada University, Aurangabad,431 004 (M.S.), India

 

 

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ABSTRACT

A new and efficient method to synthesize azlactone derivatives using alum as catalyst was performed in the absence of additional solvent. This method is environmentally friendly and affords the product azlactones in high yields after simple workup.

Keywords: Alum, solvent free, azlactone, Erlenmeyer reaction, condensation reaction

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Acknowledgements

The authors thank University Grants Commission (WRO) in Pune for financial support of the present work.

 

References and Notes

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23 It should be noted that acetic anhydride is frequently utilized in the Erlenmeyer synthesis of azlactones to promote the condensation reactions - see for instance refs 14 and 15 for the use of ca. 3 mol equivalents of acetic anhydride.

 

 

Received 8 July 2010
Revised 5 August
Accepted 25 October 2010

 

 

* To whom correspondence should be addressed. E-mail: balumadje@yahoo.com