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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350

S.Afr.j.chem. (Online) vol.62  Durban  2009

 

RESEARCH ARTICLE

 

A facile catalyst-free Pudovik reaction for the synthesis of α-amino phosphonates

 

 

K. Reddimohan NaiduI; K.R.K. Kumar ReddyI; C. Vinod KumarI; C. Naga RajuI; D. Divya SharmaII

IDepartment of Chemistry, Sri Venkateswara University, Tirupati 517 502, India
IIDepartment of Biotechnology, Sri Padmavathi Mahila University, Tirupati 517 502, India

 

 


ABSTRACT

Some imines were synthesized by the reaction of 5-amino 1-naphthol with substituted aromatic aldehydes in ethanol under reflux conditions. Dialkyl phosphites underwent addition with aromatic imines to give novel α-amino phosphonates. All the title compounds were characterized by elemental analysis, IR, 1H, 13C, 31P NMR and mass spectral data. All the newly-synthesized compounds (4a-j) exhibited moderate antibacterial and antifungal activity.

Keywords: 5-Amino-1-naphthol, imines, dialkyl phosphite, α-amino phosphonates, antimicrobial activity


 

 

Full text available only in PDF format.

 

Acknowledgements

The authors express their thanks to Prof. C.D. Reddy, Department of Chemistry, Sri Venkaleswara Universily, Tirupati, for his helpful guidance and discussion and also UGC-Delhi for providing financial assistance.

 

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Received 6 May 2009
Revised 6 August 2009
Accepted 15 October 2009

 

 

* To whom correspondence should be addressed. E-mail: naga_raju04@yahoo.co.in

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