RESEARCH ARTICLE

 

Synthesis and biological evaluation of some anthranilic acid and 2-phenylquinazoline-4(3H)-one analogues

 

 

Mrityunjay Banerjee^I; Chinmoy C. Behera^I; Guru C. Pradhan^II; M. Afzal Azam^III; Susant K. Sahu^I

^IDepartment of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa-751004, India
^IIDepartment of Chemistry, Utkal University, Bhubaneswar, Orissa-751004, India
^IIIDepartment of Pharmaceutical Chemistry, Jagathguru Sri Shivarathreeshwara College of Pharmacy, Ootacamund-643 001, India

 

 

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ABSTRACT

In the present investigation a novel series of N-(phenyl) chalconyl anthranilic acids containing pyrazolines (4a-j), tetra-hydropyrimidines (4k-o), tetrahydrothiopyrimidines (4p-t) and 2-phenylquinazolin-4(3H)-ones containing pyrazolines (8a-f), isoxazolines (8g-l), tetrahydropyrimidines (8m-r) and tetrahydrothiopyrimidines (8s-x) were synthesized and characterized by elemental analysis, FT-IR, ¹H NMR and mass spectroscopy. The title compounds (4a-t) and (8a-x) were investigated for their analgesic, anti-inflammatory, antimicrobial and in vitro protein denaturation activities. Compounds 4j and 8x were identified as lead compounds with optimum analgesic, anti-inflammatory and antimicrobial activities.

Keywords: Quinazolines, antimicrobial, analgesic, anti-inflammatory, protein denaturation

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Acknowledgements

The authors are grateful to the authorities of the Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa, India, for providing the facilities to carry out this research work. We are also thankful to Professors A.C. Dash and C.S. Panda, National Institute of Science and Educational Research, Bhubaneswar, Orissa, India, for valuable suggestions.

 

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Received 30 November 2008
Revised 24 May 2009
Accepted 19 August 2009

 

 

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