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South African Journal of Chemistry
versión On-line ISSN 1996-840X
versión impresa ISSN 0379-4350
S.Afr.j.chem. (Online) vol.62 Durban 2009
RESEARCH ARTICLE
The evaluation of novel camphor-derived ligands as catalysts in the asymmetric Henry reaction
Grant A. BoyleI; Thavendran GovenderII; Hendrik G. KrugerI; Glenn E.M. MaguireI
ISchool of Chemistry, University of KwaZulu-Natal, Durban 4000, South Africa
IISchool of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4000, South Africa
ABSTRACT
The evaluation of a series of camphor-derived ligands as catalysts in the asymmetric Henry reaction is reported. The synthesis of two novel derivatives is detailed and these molecules are also screened as catalysts in this reaction. The single crystal X-ray structure of one of the novel compounds is reported. The reaction is catalyzed with moderate to excellent yields and moderate enantioselectivity.
Keywords: Camphor, asymmetric catalysis, Henry reaction, chiral ligands
Full text available only in PDF format.
Acknowledgements
This work was supported by grants from the National Research Foundation, GUN 2046819 (South Africa), Aspen Pharmacare and the University of KwaZulu-Natal.
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Received 27 February 2009
Revised 21 April 2009
Accepted 13 May 2009
*To whom correspondence should be addressed. E-mail: kruger@ukzn.ac.za