RESEARCH ARTICLE

 

Highly efficient formylation of alcohols, thiols and aniline derivatives by a heterogeneous (HCOOH/SiO₂) system under microwave irradiation and solvent-free conditions

 

 

Ramin Ghorbani-Vaghei^I; Hojat Veisi^I; Mostafa Amiri^I; Mohammad Chegini^I; Mehdi Karimi^I; Somayeh Akbari Dadamahaleh^I; Alireza Sedrpoushan^II

^IDepartment of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamadan, Iran
^IIChemical Industries Department, Iranian Research Organization for Science and Technology (IROST), P.O. Box 15815-3538, Tehran, Iran

 

 

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ABSTRACT

A simple, rapid and efficient microwave-assisted procedure for the formylation of aniline derivatives and alcohols, using a heterogeneous (HCOOH/SiO₂) system under solvent-free conditions is reported. The method is applied to a set of amines, alcohols and thiols and short reaction times (<10 min) with high yields are reported. This protocol introduces a practical and viable green technology of solvent-free and catalyst-free reactions.

Keywords: Alcohols, anilines, SiO₂, HCOOH, microwave irradiation, solvent-free conditions

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Acknowledgement

We are thankful to Bu-Ali Sina University, Center of Excellence and Development of Chemical Methods (CECM) for financial support.

 

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Received 24 April 2008
Revised 5 November 2008
Accepted 13 January 2009

 

 

* To whom correspondence should be addressed. E-mail: rgvaghei@yahoo.com