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South African Journal of Chemistry
versão On-line ISSN 1996-840X
versão impressa ISSN 0379-4350
S.Afr.j.chem. (Online) vol.62 Durban 2009
RESEARCH ARTICLE
One-pot synthesis of substituted pyrroles with N,N,N',N' -tetrachlorobenzene-1,3-disulphonamide and N,N'-diiodo-N,N'-1,2-ethanediylbis (p-toluenesulphonamide) as novel catalytic reagents
Ramin Ghorbani-Vaghei; Hojat Veisi
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamadan 65174, Iran
ABSTRACT
In this research, N/N/N',N'-tetrachlorobenzene-1,3-disulphonamide as novel catalytic reagent and N,N'-diiodo-N,N'-1,2-ethanediylbis(p-toluenesulphonamide) as new catalyst were used for the synthesis of N-substituted pyrroles in good to excellent yields under mild conditions. These reusable reagents were compared with existing reagents and it is clear that this study is a welcome addition in the field of pyrrole synthesis.
Keywords: Pyrroles, Paal-Knorr reaction, TCBDA, NIBTS, catalytic reagent
Full text available only in PDF format.
Acknowledgements
We are thankful to the Bu-Ali Sina University, Center of Excellence and Development of Chemical Methods (CEDCM) for financial support and to the University of Sheffield for the NMR and mass spectra and CHN analyses. One of the authors (RG-V) acknowledges Prof. I. Coldham from the University of Sheffield for his kindness in hosting him as a research visitor. We heartily thank Dr Saeed Khodabakhsh for editing the manuscript.
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Received 6 October 2008
Revised 26 January 2009
Accepted 2 February 2009
* To whom correspondence should be addressed. E-mail: rgvaghei@yahoo.com