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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350

S.Afr.j.chem. (Online) vol.62  Durban  2009




Synthesis and antimicrobial activity of 2-(aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2 λ5-benzoxazaphosphinin-2-thiones



M. Anil KumarI; K. Suresh KumarI; C. Devendranath ReddyI; C. Naga RajuI; C. Suresh ReddyI; P. Hari KrishnaII

IDepartment of Chemistry, Sri Venkateswara University, Tirupati 517502, India
IIDepartment of Plant Pathology, Sri Venkateswara Agricultural College, Angrau, Tirupati 517502, India




Synthesis of 2-(aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2λ5-benzoxazaphosphinin-2-thiones (3a-j) was accomplished through a two-step process. It involves the prior preparation of 2-chloro-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2λ5-benzoxazaphosphinin-2-thione monochloride (2) and its subsequent reaction with the aminoacid ester hydrochlorides in dry tetrahydrofuran-toluene in the presence of triethylamine at various temperatures. These compounds were characterized by IR, 1H, 13C, 31P NMR and mass spectral data.

Keywords: 2-[(6-methyl-2-pyridyl) amino] methylphenol, 1,3,2-benzoxazaphosphinin-2-thione, antimicrobial activity



Full text available only in PDF format.



The authors express their thanks to Prof. C. Eswar Reddy, Sri Venkateswara Agricultural College, Acharya N.G. Ranga University, Tirupati, for his help in antimicrobial studies and the Director, IISc, Bangalore, India, for providing spectral data.



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Received 8 September 2008
Revised 6 November 2008
Accepted 2 January 2009



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