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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350

S.Afr.j.chem. (Online) vol.61  Durban  2008

 

RESEARCH ARTICLE

 

A simple, rapid and efficient one-pot protocol for the synthesis of 2-substituted benzothiazole derivatives and their antimicrobial screening

 

 

Abdul RaufI, * ; Saloni GangaI; Shweta SharmaI; Maryam ZahinII

IDepartment of Chemistry, Aligarh Muslim University, Aligarh 2002002, India
IIDepartment of Agricultural Microbiology, Aligarh Muslim University, Aligarh 2002002, India

 

 


ABSTRACT

A rapid and efficient condensation reaction of 2-aminothiophenol with various fatty acids in solvent-free conditions with or without microwave irradiation was carried out to afford the corresponding 2-substituted benzothiazole derivatives in good to excellent yields. The structures of the new products were established by elemental analyses, IR, 1H NMR, 13C NMR and mass spectral data. All the title compounds were screened for their antibacterial and antifungal activity. Most of the compounds exhibited good antimicrobial activity.

Keywords: Fatty acids, 2-substituted benzothiazole, 2-aminothiophenol, antimicrobial activity, microwave irradiation


 

 

Full text available only in pdf format.

 

Acknowledgements

The authors are grateful to the Chairman, Department of Chemistry, Aligarh Muslim University, for providing the necessary research facilities. We wish to give special thanks to Dr Iqbal Ahmad, Department of Agricultural Microbiology, AMU for antimicrobial activity of our compounds. We are also grateful to the Sophisticated Analytical Instrumentation Facility of the Central Drug Research Institute, Lucknow, India, for recording IR, NMR and mass spectra.

 

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Received 30 July 2007
Revised 31 August 2007
Accepted 14 May 2008

 

 

* To whom correspondence should be addressed. E-mail: abduloafchem@gmail.com

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