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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350

S.Afr.j.chem. (Online) vol.61  Durban  2008




Synthesis and antimicrobial activity of 3-[(4-substituted) (2-oxo-1,3-oxazolidin-3-yl) phosphoryl]-1,3-oxazolidin-2-ones



Mudumala V.N. Reddy; A.U. Ravi Sankar; B. Siva Kumar; C. Suresh Reddy*; C. Naga Raju

Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India




3-[(4-Substituted) (2-oxo-1,3-oxazolidin-3-yl)-phosphoryl]-1,3-oxazolidin-2-ones (4a-j) were synthesized through a two-step process. Bis-(2-oxo-1,3-oxazolidin-3-yl)-phosphonic chloride (2) prepared by the reaction of two moles of oxazolidin-2-one (1) with phosphorus oxychloride in dry tetrahydrofuran in the presence of triethylamine and treatment with various heterocyclic aromatic and aliphatic amines under the same experimental conditions afforded the title compounds (4a-j). They were characterized by elemental analysis, IR, NMR (1H, 13C and 31P) and mass spectroscopy. Their antimicrobial activities were also evaluated.

Keywords: 3-[(4-Substituted) (2-oxo-1,3-oxazolidin-3-yl)-phosphoryl]-1,3-oxazolidin-2-ones, oxazolidin-2-one, bis-(2-oxo-1,3-oxazolidin-3-yl)-phosphonic chloride, antimicrobial activity, spectral studies



Full text available only in pdf format.



The authors express their gratitude to Prof. C.D. Reddy, Department of Chemistry, Sri Venkateswara University, Tirupati, for helpful discussions. The Department of Atomic Energy (BRNS, Mumbai, India) is also thanked for providing financial assistance.


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Received 10 December 2007
Revised 11 March 2008
Accepted 28 March 2008



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