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South African Journal of Chemistry

versão On-line ISSN 1996-840X
versão impressa ISSN 0379-4350

S.Afr.j.chem. (Online) vol.61  Durban  2008

 

RESEARCH ARTICLE

 

Straightforward synthesis of a new series of α-(arylamino thiocarbonyloxy) hydrocarbylphosphonates

 

 

Jian-Ping LiI, *; Jun-Ge ZhuI; Rui-Jie LiuI; Feng-Ling CuiI; Ping LiuII; Guo-Sheng LiuII

ICollege of Chemical and Environmental Science, The Key Laboratory of Environmental Pollution Control Technology of Henan Province, Henan Normal University, Xinxiang, 453007, People's Republic of China
IICollege of Life Sciences, Henan Normal University, Xinxiang, 453007, People's Republic of China

 

 


ABSTRACT

A convenient, straightforward, two-step reaction of α-hydroxyhydrocarbylphosphonates with arylisothiocyanates in the presence of catalytic amounts of sodium methoxide in 1,2-dichloroethane as solvent produced various new α-(arylamino thiocarbonyloxy) hydrocarbylphosphonates in excellent yields. Their structures have been confirmed by their IR, 1H NMR and 31P NMR spectra and by elemental analysis. The preliminary antisepsis activity and protein activity of some of the compounds were identified.

Keywords: Phosphonates, arylisothiocyanates, α-hydroxyhydrocarbylphosphonates, synthesis, activity


 

 

Full text available only in pdf format.

 

Acknowledgements

We are grateful for financial support from the Natural Science Foundation of the Technology Commission of Henan Province (No. 0611021700).

 

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Received 30 November 2006
Revised 8 May 2007
Accepted 21 October 2007

 

 

* To whom correspondence should be addressed. E-mail: jplig@163.com

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