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SAMJ: South African Medical Journal

On-line version ISSN 2078-5135
Print version ISSN 0256-9574

SAMJ, S. Afr. med. j. vol.100 n.7 Pretoria Jul. 2010

 

3. Salomon L, Deray G, Jaudon MC, et al. Medication misuse in hospitalized patients with renal impairment. Int J Qual Health Care 2003; 15(4): 331-335.         [ Links ]

4. Pillans PI, Landsberg PG, Fleming AM, Fanning M, Sturtevant JM. Evaluation of dosage adjustment in patients with renal impairment. Intern Med J 2003; 33(1-2): 10-13.         [ Links ]

5. van Dijk EA, Drabbe NR, Kruijtbosch M, De Smet PA. Drug dosage adjustments according to renal function at hospital discharge. Ann Pharmacother 2006; 40(7-8): 1254-1260.         [ Links ]

6. Wong NA, Jones HW. An analysis of discharge drug prescribing amongst elderly patients with renal impairment. Postgrad Med J 1998; 74(873): 420-422.         [ Links ]

7. Sweileh WM, Janem SA, Sawalha AF, et al. Medication dosing errors in hospitalized patients with renal impairment: a study in Palestine. Pharmacoepidemiol Drug Saf 2007; 16(8): 908-912.         [ Links ]

8. Aronoff GR, Bennett WM, Berns JS, et al. Drug Prescribing in Renal Failure: Dosing Guidelines for Adults and Children. 5th ed. Philadelphia: American College of Physicians, 2007.         [ Links ]

9. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006; 145(4): 247-254.         [ Links ]

10. National Kidney Foundation. KDOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification. 2002. http://www.kidney.org/PROFESSIONALS/kdoqi/guidelines_ckd/p5_lab_g4.htm (accessed 30 June 2008).         [ Links ]

11. South African Renal Society. Guidelines for the Optimal Care of Patients on Chronic Dialysis in South Africa. 2006. www.kznhealth.gov.za/medicine/sars.pdf (accessed 30 June 2009).         [ Links ]

12. DeBellis RJ, Smith BS, Cawley PA, Burniske GM. Drug dosing in critically ill patients with renal failure: a pharmacokinetic approach. J Intensive Care Med 2000; 15(6): 273-313.         [ Links ]

13. Lameire N, Hoste E. Reflections on the definition, classification, and diagnostic evaluation of acute renal failure. Curr Opin Crit Care 2004; 10(6): 468-475.         [ Links ]

14. Chertow GM, Lee J, Kuperman GJ, et al. Guided medication dosing for inpatients with renal insufficiency. JAMA 2001; 286(22): 2839-2844.         [ Links ]

 

 

Accepted 14 January 2010.

 

 

Corresponding author: E Decloedt (eric.decloedt@uct.ac.za)

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ORIGINAL ARTICLES

 

Endogenous heparin levels in the controlled asthmatic patient

 

 

Hajierah DavidsI; Ayesha AhmedII; Ari OberholsterIV; Christo van der WesthuizenIV; Mervyn MerV; Ivan HavlikIII

IBSc, BSc (Hons). Department of Pharmacy and Pharmacology, University of the Witwatersrand, Johannesburg
IIMSc, PhD. Department of Pharmacy and Pharmacology, University of the Witwatersrand, Johannesburg
IIIMSc, PhD. Department of Pharmacy and Pharmacology, University of the Witwatersrand, Johannesburg
IVNat Dip Pulmonol. Department of Pulmonology and Critical Care, University of the Witwatersrand
VMB BCh, Dip PEC (SA), FCP (SA), MMed (Int Med), FCCP, FRCP (Lond). Department of Pulmonology and Critical Care, University of the Witwatersrand

 

 


ABSTRACT

BACKGROUND: Since heparin possesses anti-inflammatory properties, it is hypothesised that asthmatic patients have decreased levels of circulating heparin compared with healthy individuals.
DESIGN: We compared endogenous heparin levels in controlled asthmatic patients (53 adults) from the Asthma Clinic at Johannesburg General Hospital with those of healthy controls (26 adults) from the general population. Heparin levels in the blood samples were tested using the Chromogenix Coatest Heparin kit.

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