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SAMJ: South African Medical Journal

On-line version ISSN 2078-5135
Print version ISSN 0256-9574

SAMJ, S. Afr. med. j. vol.100 n.7 Pretoria Jul. 2010


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Accepted 14 January 2010.



Corresponding author: E Decloedt (

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Endogenous heparin levels in the controlled asthmatic patient



Hajierah DavidsI; Ayesha AhmedII; Ari OberholsterIV; Christo van der WesthuizenIV; Mervyn MerV; Ivan HavlikIII

IBSc, BSc (Hons). Department of Pharmacy and Pharmacology, University of the Witwatersrand, Johannesburg
IIMSc, PhD. Department of Pharmacy and Pharmacology, University of the Witwatersrand, Johannesburg
IIIMSc, PhD. Department of Pharmacy and Pharmacology, University of the Witwatersrand, Johannesburg
IVNat Dip Pulmonol. Department of Pulmonology and Critical Care, University of the Witwatersrand
VMB BCh, Dip PEC (SA), FCP (SA), MMed (Int Med), FCCP, FRCP (Lond). Department of Pulmonology and Critical Care, University of the Witwatersrand




BACKGROUND: Since heparin possesses anti-inflammatory properties, it is hypothesised that asthmatic patients have decreased levels of circulating heparin compared with healthy individuals.
DESIGN: We compared endogenous heparin levels in controlled asthmatic patients (53 adults) from the Asthma Clinic at Johannesburg General Hospital with those of healthy controls (26 adults) from the general population. Heparin levels in the blood samples were tested using the Chromogenix Coatest Heparin kit.

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