SciELO - Scientific Electronic Library Online

vol.98 número4Paediatric surgery: Birth of a new specialty or a coming of age?Eating disorders in South Africa: An inter-ethnic comparison of admission data índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados



Links relacionados

  • En proceso de indezaciónCitado por Google
  • En proceso de indezaciónSimilares en Google


SAMJ: South African Medical Journal

versión On-line ISSN 2078-5135
versión impresa ISSN 0256-9574

SAMJ, S. Afr. med. j. vol.98 no.4 Cape Town abr. 2008




A centile chart for fetal weight for gestational ages 24 - 27 weeks



G B TheronI; L GeertsII; A M TheronIII; M L ThompsonIV

IMD, MCOG (SA), MMed (O&G), BSc Hons. Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Stellenbosch, University and Tygerberg Hospital, Parow, W Cape
IIMRCOG, BSc Hons. Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Stellenbosch, University and Tygerberg Hospital, Parow, W Cape
IIIRN. Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Stellenbosch, University and Tygerberg Hospital, Parow, W Cape
IVPhD. Biostatistics Unit, Medical Research Council, Durban, and Department of Biostatis-tics, University of Washington, Seattle, USA




To the Editor: The centile chart currently in use for Western Cape birth weight for gestational age covers a gestational age range from 28 to 42 weeks.1 Advances in maternal, fetal and neonatal medicine allow interventions prior to 28 weeks; a growing need therefore exists to extend the chart down to at least 24 weeks. Birth or fetal weight centile charts used in the USA, Canada and the UK provide centiles commencing from either 22 or 24 weeks.2,3 These charts may not, however, be appropriate for the population of the Western Cape.4 The accuracy of fetal or birth weight for gestational age centile charts can be improved by including only women who had their gestational age confirmed by early ultrasound prior to gestational age of 24 weeks.5 In addition, the birth weight of preterm delivered neonates should not be used to establish a norm, as these infants were delivered following maternal and/or obstetric complications.5 The ultrasonic estimated fetal weight (EFW) is the method of choice to establish a reference range for weight for gestational age in early gestation.6 The EFW should be used in preference to any single ultrasound measurement as it relies on multiple measurements.6 The aim of this study was to construct a centile chart from 24 to 27 weeks for fetal weight for gestational age, taking the above criteria into account.



A cohort of 246 women with singleton uncomplicated pregnancies and early ultrasound-confirmed gestational age was recruited from the community antenatal clinics in the Tygerberg area (Elsies River, Bishop Lavis, Bellville South, Delft and Belhar). Sequential patients complying with the inclusion criteria were included in the study. The patients were referred to Tygerberg Hospital for ultrasound fetal weight estimates, using the Hadlock formula with the ANTARES (Siemens) ultrasound equipment, by a limited number of skilled ultrasonologists.7 Each patient had 2 ultrasound weight estimates: about half the cohort at 24 and 26 weeks, and about half at 25 and 27 weeks. Accurate sequential fetal weight estimates provided the database for calculating the centiles in this gestational age range. Additional demographic information for each patient was collected, taking care to record information that may influence fetal weight, e.g. parity, smoking and body mass index (BMI). The patients were followed up until delivery and the outcome of the pregnancies was determined.

Data analysis

The distribution of fetal weights and corresponding centile curves were estimated by using Cole's LMS method with sandwich variance estimation to accommodate the repeated measurements of each fetus.8 This approach assumes that, at any gestational age, the distribution of fetal weight can be transformed to normality by a suitable power transformation. The 3rd, 10th, 50th, 90th and 97th percentiles for each gestational age (24 - 27 weeks) were estimated. All analyses were performed by Stata Version 9.1.9



A total of 246 patients were included in the study, presenting a total of 459 fetal weight estimates that contributed to the centile chart (Fig. 1). The ethnic make-up of the study sample was 224 (91.1%) coloured, 20 (8.1%) black, and 2 (0.8%) white. Thirty-three women had only one fetal weight estimate, values were missing for the smoking status of 2 women, and 39 women for whom weight and/or height at the first antenatal visit were not recorded, were not available for determining their body mass index (BMI). The median age was 23 (range 14 - 41) years, median gravidity was 1 (range 1 - 6), and median BMI was 24.7 kg/m2 (range 16.9 - 43.6). Labour was induced in 26 (10.6%) patients, and the mode of delivery was normal vertex delivery in 210 (85.4%), caesarean section 29 (11.8%), assisted deliveries 5 (2.0%), and breech deliveries 2 (0.8%). The median gestational age at delivery was 39 weeks (range 29 - 43), the median birth weight 3 070 g (range 980 - 5 120) and the median 5-minute Apgar score 10 (range 5 - 10). Of the subjects, 38.5 % acknowledged smoking during pregnancy.



The percentages of male and female infants was 49% and 51%, respectively. There were 3 intra-uterine deaths (IUDs) and 1 early neonatal death, with a perinatal mortality rate of 16 per 1 000 deliveries. The primary causes of the 3 IUDs were a cord complication; acute pyelonephritis, vomiting and dehydration in a patient admitted with an IUD; and a stillborn baby delivered elsewhere, with no further information able to be obtained. The early neonatal death (day 1) was caused by a congenital abnormality. The infant had dysplastic kidneys that resulted in severe oligohydramnios and hypoplastic lungs.

Parity (p=0.006) and smoking (p=0.023) significantly affected mean fetal weight. On average, the fetal weight for nulliparous women was 39.2 g higher than that of multiparous women (of the same smoking status), and smokers had a fetal weight 32.4 g lower than non-smokers (of the same parity status). No association of fetal weight with maternal BMI index was found. The estimated 10th, 50th and 90th percentiles of fetal weight at 27 weeks' gestation were 823, 981 and 1 176 g, respectively. The centile chart for birth weight currently in use commences at 28 weeks' gestation, with the 10th, 50th and 90th percentiles at 747, 1 149 and 1 471 g, respectively.1



Pregnancy centile charts may be customised by characteristics such as maternal race, age, BMI and parity.3,10-12 The aim of this confined study was, however, to produce a single 'hard copy' fetal weight chart to be used in hospitals and clinics that do not have immediate access to the computers and software that would be necessary to implement customised charts. We noted further that the women in our sample, who are representative of the population served by Tygerberg Hospital, are predominantly of the coloured group. We constructed centile charts for the coloured group alone, but these centiles were not distinguishable from the estimates based on the entire sample (data not shown).

Knowledge of centiles for fetal weight at earlier gestational ages will contribute towards more accurate decisions late in the second trimester. Furthermore, when gestational age is unknown, the ultrasound estimated weight could be plotted on the centile chart to estimate gestational age. Smoking affects fetal weight at an early gestational age.



1. Theron GB, Thompson ML. A centile chart for birth weight for an urban population of the Western Cape. S Afr Med J 1995; 85: 1289-1292.         [ Links ]

2. Oken E, Kleinman KP, Rich-Edwards J, Gillman MW. A nearly continuous measure of birth weight for gestational age using a United States national reference. BMC Pediatr 2003; 3: 6-15.         [ Links ]

3. Gelbaya TA, Nardo LG. Customised fetal growth chart: a systematic review. J Obstet Gynaecol 2005; 25(5): 445-450.         [ Links ]

4. Wilcox MA, Gardosi J, Mongelli M, Ray C, Johnson I. Birth weight from pregnancies dated by ultrasonography in a multicultural British population. BMJ 1993a; 307: 588-591.         [ Links ]

5. Doubilet PM, Benson CB, Nadel AS, Ringer SA. Improved birth weight table for neonates developed from gestations dated by early ultrasonography. J Ultrasound Med 1997; 16: 241-249.         [ Links ]

6. Zeitlin J, Ancel PY, Saurel-Cubezolles MJ, Papiernik E. The relationship between intrauterine growth restriction and preterm delivery: an empirical approach using data from a European case-control study BJOG 2000; 107: 750-758.         [ Links ]

7. Hadlock FP, Harrist RB, Sharman RS, Deter RL, Park SK. Estimation of fetal weight with the use of head, body and femur measurements - a prospective study. Am J Obstet Gynecol 1985; 151: 333-337.         [ Links ]

8. Cole TJ. Fitting smoothed centile curves to reference data. JR Statist Soc B 1988; 26: 211-252.         [ Links ]

9. Stata Statistical Software: Release 9.1 College Station, Texas: Stata Corporation, 2005.         [ Links ]

10. Gardosi J. Customized growth curves. Clin Obstet Gynecol 1997; 40: 715-722.         [ Links ]

11. Theron GB, Thompson ML. A centile chart for weight gain in pregnancy for the urban population of the Western Cape, South Africa. Int J Gynecol Obstet 1990; 33: 127-133.         [ Links ]

12. Thompson ML, Theron GB, Fatti LP. Predictive value of conditional centile charts for weight and fundal height in pregnancy in detecting light for gestational age births. Eur J Obstet Gyn 1997; 72: 3-8.         [ Links ]



G Theron

Accepted 27 November 2007

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons