SciELO - Scientific Electronic Library Online

 
vol.51 número4Gastric heterotopia causing jejunal ulceration and obstructionSalmonella thyroiditis: A case report and review of the literature índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • En proceso de indezaciónSimilares en Google

Compartir


South African Journal of Surgery

versión On-line ISSN 2078-5151

S. Afr. j. surg. vol.51 no.4 Cape Town ene. 2013

 

CASE REPORT

 

The ectopic posterior pituitary gland

 

 

N Mahomed; T Motshudi

Department of Diagnostic Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Correspondence

 

 


ABSTRACT

An ectopic posterior pituitary gland is a rare condition and may present with an empty pituitary fossa, hypoplasia or absence of the infundibular stalk and resultant short stature due to growth hormone deficiency. The location of the ectopic lobe can vary, but it is most commonly situated along the median eminence in the floor of the third ventricle. We report a case of an ectopic posterior pituitary gland, describe the causes and discuss the diagnostic imaging features.


 

 

Case report

An 8-year-old boy presented to paediatric endocrinology with short stature, delayed bone age and biochemical features suggestive of hypopituitarism. Magnetic resonance imaging of the brain demonstrated a flattened anterior pituitary gland within the sella, associated with absence of the infundibular stalk and an ectopic posterior pituitary gland (Fig. 1). There was associated tonsillar ectopia due to the small cranium.

 

 

Discussion

An ectopic posterior pituitary gland is a rare condition and may present with an empty pituitary fossa, hypoplasia or absence of the infundibular stalk and resultant short stature due to growth hormone deficiency.[1] It may be associated with septo-optic dysplasia, Chiari I malformation, agenesis of the corpus callosum, Kallmann sydrome and peri-ventricular heterotopias.[1,2] The location of the ectopic lobe can vary, but it is most commonly located along the median eminence in the floor of the third ventricle.[1,2]

Causes of an ectopic posterior pituitary gland include defective neuronal migration during embryogenesis, tumours, trauma, or surgical transection of the pituitary stalk.[3,4] Usually the anterior pituitary gland is absent, or attenuated and reduced in height, and the infundibular stalk may not be visible.[3] The infundibular stalk is best assessed after injection of gadolinium. Signal hyperintensity in the posterior aspect of the pituitary gland on T1-weighted images is related to the paramagnetic effect of the vasopressin-neurophysin II co-peptin complex.[1]

 

REFERENCES

1. Ginat DT, Meyers SP. Intracranial lesions with high signal intensity on T1-weighted MR images: Differential diagnosis. Radiographics 2012;32(2):499-516. [http://dx.doi.org/10.1148/rg.3221057611        [ Links ]

2. Mitchell LA, Thomas PQ, Zacharin MR, Scheffer IE. Ectopic posterior pituitary lobe and periventricular heterotopia: Cerebral malformations with the same underlying mechanism? AJNR Am J Neuroradiol 2002;23(9):1475-1481.         [ Links ]

3. Saleem SN, Said AH, Lee DH. Lesions of the hypothalamus: MR imaging diagnostic features. Radiographics 2007;27(4):1087-1108. [http://dx.doi.org/10.1148/rg.274065123]        [ Links ]

4. Van der Linden AS, Van Es HW. Case 112: Pituitary stalk transection syndrome with ectopic posterior pituitary gland. Radiology 2007;243(2):594-597. [http://dx.doi.org/10.1148/radiol.2432040385]        [ Links ]

 

 

Correspondence:
N Mahomed
(nasreen.mahomed@wits.ac.za)

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License