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South African Journal of Science

versión On-line ISSN 1996-7489
versión impresa ISSN 0038-2353

S. Afr. j. sci. vol.103 no.5-6 Pretoria may./jun. 2007

 

NEWS & VIEWS

 

Asthma, Euphorbia hirta and its anti-inflammatory properties

 

 

O.E. Ekpo; E. Pretorius

Department of Anatomy, Faculty of Health Sciences. University of Pretoria, P.O. Box 2034, Pretoria 0001, South Africa

 

 


ABSTRACT

Euphorbia hirta is a plant used in traditional medicine for a variety of diseases, such as cough, asthma, colic dysentery and genito-urinary infection. This plant, belonging to the family Euphorbiaceae, is also known as the Australian asthma herb or Queensland asthma weed, and is not toxic when taken in typical dosages. In South Africa, it is commonly used for asthma, which is one of the most common respiratory complaints. Although corticosteroids are considered the best means of defence against this debilitating illness, many people, especially in poor countries, rely on herbal remedies for its treatment. We discuss recently published results to assess the effect of the plant using the BALB/c murine asthma model. We also review the different compounds found in plant extracts, in an attempt to understand the reason for its anti-inflammatory properties. We conclude that the flavonoids quercitrin (converted to quercetin in the alimentary canal) and myricitrin, as well as the sterols 24-methy-lene-cycloartenol and -sitosterol, exert note-worthy and dose-dependent anti-inflammatory activity. The triterpene ß-amyrin also seems to exert a similar anti-inflammatory activity. Tannins and tannic acid derivatives, also present in the plant, have antiseptic effects and the two triterpenoids, taraxerone (EH-1) and 11a,12a-oxidotaraxerol (EH-2), in E. hirta demonstrate antibacterial and antifungal properties. The effectiveness of E. hirta in treating asthma may lie predominantly in the synergistic relationships between the flavonoids, sterols and triterpenoids.


 

 

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References

1. Masoli M., Fabial D., Holt S. and Beasley R. (2004). The global burden of asthma: Executive summary of the GINA Dissemination Committee Report. Allergy 59, 469-478.         [ Links ]

2. Kariyawasam H.H. and Robinson D.S. (2005). Airway remodeling in asthma: models and supermodels? Clin. Exp. Allergy 35(2), 117.         [ Links ]

3. Undem B.J. and Lichtenstein L.M. (2001). Drugs used in the treatment of asthma. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, eds J.G. Hardman and L.E. Limbird, pp. 733-754, 10th Int. Edn. McGraw-Hill, Whitby, Ontario.         [ Links ]

4. Puckree T., Mkhize M., Mgobhozi Z. and Lin J. (2002). African traditional healers: what healthcare professionals need to know. Int. J. Rehab. Res. 25, 247-251.         [ Links ]

5. Mulholland D.A. and Drewes S.E. (2004). Global phytochemistry: indigenous medicinal chemistry on track in Southern Africa. Phytochemistry 65, 769-782.         [ Links ]

6. Van Wyk B-E., Van Oudtshoorn B. and Gericke N. (2000). Medicinal Plants of South Africa, 2nd edn. Briza, Pretoria.         [ Links ]

7. Pinn G. (2001). Herbal therapy in respiratory diseases. Aust. Fam. Physician 30(8), 775-779.         [ Links ]

8. Johnson P.B., Abdurahman E.M., Tiam E.A., Abdu-Aguye I. and HussainiI.M. (1999). Euphorbia hirta leaf extracts increase urine output and electrolytes in rats. J. Ethnopharmacol. 65(1), 63-69.         [ Links ]

9. Chopra R.N., Chopra I.C. and Verma B.S. (1969). Supplement to Glossary of Indian Medicinal Plants, pp. 63-64. CSIR, New Delhi.         [ Links ]

10. Nadkarni K.M. (1976). The Indian Material Medica, Revised edition. Popular Prakhshan, Mumbai.         [ Links ]

11. Kapoor S.L. and Mitra R. (1979). Herbal drugs in Indian pharmaceutical industry, 85 Economic Botany Information Service, National Botanic Research Institute, Lucknow, India.         [ Links ]

12. Jain S.K. (1996). Medicinal Plants, 6th edn, pp. xiii and 178. National Book Trust, New Delhi.         [ Links ]

13. Bhatnagar VP, Anil K. and Srivastava J N. (2000). Wild medicinal herbs of Agra. J. Med. Aroma. Plant Sci. 22/4A; 23/1A, 464-467.         [ Links ]

14. Oliver B. (1959). In Medicinal Plants in Nigeria, pp. 138-149. College of Arts, Science and Technology, Ibadan.         [ Links ]

15. Kokwaro J.O. (1976). Medicinal Plants in East Africa. East African Literature Bureau, Nairobi.         [ Links ]

16. Wong Ting-Fook. (1980). Medicinal Plants of Mauritius. ENDA Publications No.10. Dakar, Senegal.         [ Links ]

17. Pretorius E., Ekpo O.E. and Smit E. (in press). Comparative ultrastructural analyses of platelets and fibrin networks using the murine model of asthma. Experimental Toxicology and Pathology.         [ Links ]

18. Kay A.B., Phipps S. and Robinson D.S. (2004). A role for eosinophils in airway remodelling in asthma. Trends Immunol. 25(9), 477-482.         [ Links ]

19. Chen L. (1991). Polyphenols from leaves of Euphorbia hirta L. Zhongguo Zhong Yao Za Zhi 16(1), 38-39, 64.         [ Links ]

20. Miller A.L. (2001). The etiologies, patho-physiology and alternative/complementary treatment of asthma. Altern. Med. Rev. 6(1), 20-47.         [ Links ]

21. Skidmore-Roth L. (2001). Mosby's Handbook of Herbs and Natural Supplements. Mosby, St Louis, MO.         [ Links ]

22. Williams R.J., Spencer J.P.E. and Rice-Evans C. (2004). Flavonoids: antioxidants or signaling molecules? Free Radical Biol. Med. 36(7), 838-849.         [ Links ]

23. Kobuchi H., Roy S., Sen C.K., Nguyen H.G. and Packer L. (1999). Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. Am. J. Physiol. 277, C403-C411.         [ Links ]

24. Kong A.N., Yu R., Chen C., Mandlekar S. and Primiano T. (2000). Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch. Pharm. Res. 23, 1-16.         [ Links ]

25. Camuesco D., Comalada M., Rodriguez-Cabezas M.E., Nieto A., Lorente M.D., Concha A., Zarzuelo A. and Galvez J. (2004). The intestinal anti-inflammatory effect of quercitrin is associated with an inhibition in iNOS expression. Br. J. Pharmacol. 143(7), 908-918.         [ Links ]

26. Comalada M., Camuesco D., Sierra S., Ballester I., Xaus J., Galvez J. and Zarzuelo A. (2005). In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappa B pathway. Eur. J. Immunol. 35(2), 584-592.         [ Links ]

27. Spencer J.P.E., Kuhnle G.G.C., Williams R.J. and Rice-Evans C. (2003). Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochem. J. 372, 173-181.         [ Links ]

28. Morand C., Manach C., Crespy V. and Remesy C. (2000). Respective bioavailability of quercetin aglycone and its glycosides in a rat model. Biofactors 12, 169-174.         [ Links ]

29. Galvez J., Crespo M.E., Jimenez J., Suarez A. and Zarzuelo A. (1993). Antidiarrhoeic activity of quercitrin in mice and rats. J. Pharm. Pharmacol. 45(2), 157-159.         [ Links ]

30. Atallah A.M., Nicholas H.J. (1972). Triterpenoids and steroids of Euphorbia pilulifera. Phytochemistry 2, 1860-1868.         [ Links ]

31. Martinez-Vazquez M., Apan TO.R., Lazcano M.E. and Bye R. (1999). Anti-inflammatory active compounds from the n-hexane extract of Euphorbia hirta. Rev. Soc. Quim. Mexico 43, 103-105.         [ Links ]

32. Yoshida T., Namba O., Chen L. and Okuda T. (1990). Euphorbin E: A Hydrolysable tannin dimer of highly oxidized structure from Euphorbia hirta. Chem. Pharmaceut. Bull. (Tokyo) 38, 1113-1115.         [ Links ]

33. Ahmed A.M. and Nicholas H.J. (1972). Triterpenoids and steroids of Euphorbia pilulifera. Phytochemistry 11, 1860.         [ Links ]

34. Abu-Sayeed M., Ali M.A., Bhattacharjee P.K., Islam A., Astaq G.R.M., Khan M. and Yeasmin S. (2005). Biological evaluation of extracts and triterpenoids of Euphorbia hirta. Pakistan J. Sci. Ind. Res. 48(2), 122-125.         [ Links ]

 

 

Author for correspondence. E-mail: resia.pretorius@up.ac.za

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