RESEARCH IN ACTION

 

Nitrous oxide and carbon dioxide: Their similar and contrasting biological effects

 

 

M.A. Gillman; F.J. Lichtigfeld

South African Brain Research Institute, 6 Campbell St, Waverley, Johannesburg 2090, South Africa.

 

 

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ABSTRACT

The similar and contrasting biological properties of CO₂ and N₂O appear to reflect fundamental biological processes in both very simple and the most complex organisms.

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REFERENCES

1. Laing M. (2003). Some thoughts on the structure and behaviour of N₂O, laughing gas. S. Afr. J. Sci. 99, 109-114.         [ Links ]

2. Bowman W.C. and Rand M.J. (1980). Textbook of Pharmacology, 2nd edn, pp. 39.14-15. Blackwell, Oxford.         [ Links ]

3. Dennis D.T. and Turpin D.H. (Eds)(1990). Plant Physiology, Biochemistry and Molecular Biology. Maskew Miller Longman, Singapore.         [ Links ]

4. Hyun J., Chaudhuri G. and Fakuto J.M. (1999). The reductive metabolism of nitric oxide in hepatocytes: possible interaction with thiols. Drug. Metab. Dispos. 27, 1005-1009.         [ Links ]

5. Lipschultz F., Zafiriou O.C, Wofsy S.C., McElroy M.B., Valois F.W. and Watson S.W. (1981). Production of NO and N₂O by soil nitrifying bacteria. Nature 294, 641-643.         [ Links ]

6. Smart R.S. and Bloom A.J. (2001). Wheat leaves emit nitrous oxide during nitrate assimilation. Proc. Natl Acad. Sci. USA 98, 7875-7878.         [ Links ]

7. Einarsdottir O. and Caughey WS.(1988). Interactions of the anesthetic N₂O with bovine heart cytochrome c oxidase. J. Biol. Chem. 263, 9199-9205.         [ Links ]

8. Sowa S., Dong A., Roos E.E. and Caughey W.S. (1987). The anesthetic nitrous oxide affects dioxygen utilization by bovine heart and bean seed mitochondrial particles. Biochem. Biophys. Res. Commun. 144, 643-648.         [ Links ]

9. Falkowski P.G. (1997). Evolution of the nitrogen cycle and its influence on the biological sequestration of CO₂ in the ocean. Nature 387, 272-275.         [ Links ]

10. Trudell J.R. (1985).Metabolism of nitrousoxide. In Nitrous oxide/N₂O, ed. E.I. Eger II, pp. 204-210. Elsevier, New York.         [ Links ]

11. Gillman M.A., Kok L. and Lichtigfeld F.J. (1980). Paradoxical effect of naloxone on nitrous oxide analgesia in man. Eur. J. Pharmacol. 61, 175-177.         [ Links ]

12. Gillman M.A. and Lichtigfeld F.J. (1981). A comparison of the effect of morphine sulphate and nitrous oxide analgesia on chronic pain states in man. J. Neurol. Sci. 45, 41-45.         [ Links ]

13. Gillman M.A. and Lichtigfeld F.J. (1981). The similarity of the action of nitrous oxide and morphine. Pain 10, 110.         [ Links ]

14. Bredt D.S., Hwang P. M. and Snyder S.H. (1990). Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347, 768-770.         [ Links ]

15. Meller S.T. and Gebhart G.F. (1993). Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 52, 127-136.         [ Links ]

16. Gillman M.A. and Lichtigfeld F.J. (1994). NO comments. Nature 367, 28.         [ Links ]

17. Gillman M.A. and Lichtigfeld F.J. (1994). Opioid properties of psychotropic analgesic nitrous oxide (laughing gas). Perspect. Biol. Med. 38, 125-138.         [ Links ]

18. Ganong W.F. (1995). In Review of Medical Physiology, 17th edn, pp. 625-639. Prentice-Hall, London.         [ Links ]

19. Marshall B.E. and Longnecker D.E. (1996). General anesthetics. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th edn, ed. J.G. Hardman, L.E. Limbird, P.B. Molinoff, R.W. Ruddon and A.G. Gilman, pp. 307-330. McGraw-Hill, New York.         [ Links ]

20. Eickenhoff R.G. and Longnecker D.E. (1996). The therapeutic gases. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th edn, ed. J.G. Hardman, L.E. Limbird, P.B. Molinoff, R.W. Ruddon and A.G. Gilman, pp. 349-359. McGraw-Hill, New York        [ Links ]

21. Gillman M.A. (1986). Analgesic (sub-anesthetic) nitrous oxide interacts with the endogenous opioid system: a review of the evidence. Life Sci. 39, 1209-1221.         [ Links ]

22. Gillman M.A. (1989). Physico-chemical basis of nitrous oxide activity at opioid receptors. S. Afr. J. Sci. 85, 280-281.         [ Links ]

23. Gillman M.A. (1993). Analgesic nitrous oxide should join the opioid family after almost two centuries. S. Afr. J. Sci. 89, 25-24.         [ Links ]

24. Alexander F. (1876). In An introduction to Veterinary Pharmacology, 3rd edn, pp. 99-122. Churchill Livingstone, Edinburgh.         [ Links ]

25. Reisine T. and Pasternak G. (1996). Opioid analgesics and antagonists. In Goodman and Gilman's The Pharmacological Basis ofTherapeutics, 9th edn, ed. J.G. Hardman, L.E. Limbird, P.B. Molinoff, R.W. Ruddon and A.G. Gilman, pp. 521-555. McGraw-Hill, New York.         [ Links ]

26. Alexander F. (1976) In An Introduction to Veterinary Pharmacology, 3rd edn, pp. 184-190. Churchill Livingstone, Edinburgh.         [ Links ]

27. Hobbs W.R., Rall T.W. and Verdoorn T.A. (1996). Hypnotics and sedatives. In Goodmanand Gilman's The Pharmacological Basis of Therapeutics, 9th edn, ed. J.G. Hardman, L.E. Limbird, P.B. Molinoff, R.W. Ruddon and A.G. Gilman, pp. 361-396. McGraw-Hill, New York.         [ Links ]

28. Waller D.D. (1985). Molecular identification of the mode of interactions of nitrous oxide with the opiate receptor system. M.Sc. thesis, University of the Witwatersrand, Johannesburg.         [ Links ]

29. Gamble G.D. and Milne R.J. (1990). Hypercapnia depresses nociception: endogenous opioids implicated. Brain Res. 514, 198-205.         [ Links ]

30. Clark M. and Brunick A. (1999). Handbook of Nitrous Oxide and Oxygen Sedation, pp. 151-155. Mosby, St Louis.         [ Links ]

31. Ori C., Ford-Rice F. and London E.D. (1989). Effects of nitrous oxide and halothane on mu and kappa opioid receptors in guinea-pig brain. Anesthesiology 70, 541-544.         [ Links ]

32. Moody E.J., Mattson M., Newman A.H., Rice K.C. and Skolnick P. (1989). Stereospecific reversal of nitrous oxide analgesia by naloxone. Life Sci. 44, 703-709.         [ Links ]

33. Daras C., Cantrill R.C. and Gillman M.A. (1983). ³(H)-Naloxone displacement: evidence for nitrous oxide as an opioid agonist. Eur. J. Pharmacol. 89, 177-178.         [ Links ]

34. Eisele J.H. (1985). Cardiovascular effects of nitrous oxide analgesia. In Nitrous Oxide/N₂O, ed. E.I. Eger II, pp. 126-156. Elsevier, New York.         [ Links ]

35. Ebert T.J. and Kampine JP. (1989). Nitrous oxide augments sympathetic outflow: direct evidence from human peroneal nerve recordings. Anesth. Analg. 69, 444-449.         [ Links ]

36. Guo T., Davis M.F., Kingery W.S., Patterson A.J., Limbird L.E. and Maze M. (1999). Nitrous oxide produces antinociceptive response via α_2B and/or α_2C adrenoceptor subtypes in mice. Anesthesiology 90, 470-76.

37. Williams P.L. (Ed.) (1995). Gray's Anatomy, 38th edn, pp. 1076-1077. Churchill Livingstone, New York.         [ Links ]

38. Matheny J.L., Westphal K.A., Richardson D.R. and Roth G.I. (1991). Macro- and microvascular effects of nitrous oxide in the rat. Anesth. Prog. 38, 57-64.         [ Links ]

39. Roth G.I, Matheny J.L., Falace D.A., O'Reilly J.E. and Norton J.C. (1984). Effect of age on the digit blood flow response to sedative concentrations of nitrous oxide. Anesth. Prog. 31, 17-22.         [ Links ]

40. Kitahata L.M, Taub A. and Sato I. (1971). Lamina-specific suppression of dorsal horn unit activity by nitrous oxide and by hyperventilation. J. Pharmacol. Exp. Ther. 176, 101-108.         [ Links ]

41. Gillman M.A. and Lichtigfeld F.J. (1985). A pharmacological overview of opioid mechanisms mediating analgesia and hyperalgesia. Neurolog. Res. 7, 106-119.         [ Links ]

42. LaVerne A.A. (1953). Rapid coma technique of carbon dioxide inhalation therapy. Dis. Nerv. Syst. 14, 141-44.         [ Links ]

43. Scott W., Woods M.D., Chrystal J.H., Cynthia L., D'Amico C.L., Heninger M.D. and Charney M.D. (1988). A review of behavioural and pharmacologic studies relevant to the application of CO₂ as a human model of anxiety. Psychopharmacol. Bull. 24, 149-153.         [ Links ]

44. Russel R.W. and Steinberg H. (1955). Effects of nitrous oxide on reactions to 'stress'. Quat. J. Exp. Psychol. 7, 67-73.         [ Links ]

45. Gillman M.A. and Katzeff I.E. (1988). Does opioid uncoupling of adrenal responses mediate opioid anti-stress effects. Med. Sci. Res. 16, 207-209.         [ Links ]

46. Gillman M.A. and Katzeff I.E. (1989). Antistress hormonal responses of analgesic nitrous oxide. Int. J. Neurosci. 49, 199-202.         [ Links ]

47. Clark M. and Brunick A. (2003). Handbook of Nitrous Oxide and Oxygen Sedation, pp. 28-32. Mosby, St Louis.         [ Links ]

48. Silver G.A. (1953). Carbon dioxide therapy. Sthn Med. J. 46, 283-286.         [ Links ]

49. Brill N.Q., Crumpton E., Eiduson S., Grayson H.M., Hellman L.I. and Richards R.A. (1959). Relative effectiveness of various components of electroconvulsive therapy. Arch Neurol. Psychiat. 81, 627-635.         [ Links ]

50. Zádor J. (1928). Der Lachgas (N₂O) - Rausch in seiner Bedeutung für Psychiatrie und Neurologie. Arch. Psychiatrie 84, 1-71.         [ Links ]

51. Lichtigfeld F.J. and Gillman M.A. (2003). Another marker for depression. Int. J. Neuropsychopharmacol. 6, 91-92.         [ Links ]

52. Lichtigfeld F.J. and Gillman M.A. (1982). The treatment of alcoholic withdrawal states with oxygen and nitrous oxide. S. Afr. Med. J. 61, 349-351.         [ Links ]

53. Gillman M.A. and Lichtigfeld F.J. (2004). Enlarged double-blind randomised trial of benzodiaze-pines against psychotropic analgesic nitrous oxide for alcohol withdrawal. Addict. Behav. 29, 1183-1187.         [ Links ]

54. Kripke B.J. and Hechtman H.B. (1972). Nitrous oxide for pentazocine addiction and intractable pain. Anesth. Analg. 51, 520-526.         [ Links ]

55. Gillman M.A. and Lichtigfeld F.J. (1985). Analgesic nitrous oxide: adjunct to clonidine for opioid withdrawal. Am. J. Psychiatry 142, 784-785.         [ Links ]

56. LaVerne A.A. (1973). Carbon dioxide therapy (CDT) of addictions. Behav. Neuropsychiat. 4, 13-32.         [ Links ]

57. Lichtigfeld F. J. and Gillman M.A. (1982). The treatment of alcoholic withdrawal states with oxygen and nitrous oxide. S. Afr. Med. J. 61, 349-351.         [ Links ]

58. Kripke B.J. and Hechtman H.B. (1972). Nitrous oxide for pentazocine addiction and intractable pain. Anesth. Analg. 51, 520-526.         [ Links ]

59. Gillman M.A. and Lichtigfeld F.J. (1985). Analgesic nitrous oxide: adjunct to clonidine for opioid withdrawal. Am. J. Psychiatry 142, 784-785.         [ Links ]

 

 

^{We thank Mary Scholes and Mike Cramer for advice on the section dealing with plant physiology.
*} Author for correspondence. E-mail: mag@sabri.org.za
^** Deceased.