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Onderstepoort Journal of Veterinary Research

On-line version ISSN 2219-0635
Print version ISSN 0030-2465

Onderstepoort j. vet. res. vol.75 n.3 Pretoria  2008




Intramammary antibiotic withdrawal periods for dairy goats compared to those for dairy cattle



I.M. PetzerI; E.F. DonkinII; E. Du PreezI; J. KarzisI; T.J. Van Der SchansI; J.C. WatermeyerI; R. Van ReenenI

IDepartment of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa
IIDepartment of Animal and Wildlife Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, 0002 South Africa




This study investigated the withdrawal periods (WP) of two intramammary antibiotics Cloxamast LC (Intervet SA) and Spectrazol Milking Cow (Schering-Plough Animal Health) in dairy goats and compared them to those recommended for use in cattle.
The WP for Cloxamast LC, measured by the Thermo Resistant Inhibitory Substances (TRIS) test, was 60 h in composite samples, 56 h in udder half samples, and the dye was visible for up to 56 h. The WP was significantly shorter than the 72 h recommended WP for use in cattle. It was however significantly longer when the 24 h safety margin (48 h) was subtracted from the recommended WP for cattle. For Spectrazol Milking Cow the antibiotics could be detected by the TRIS test for 61 h in composite samples and 59 h in udder half samples. This did not differ significantly from the recommended 60 h WP for cattle. However, it was significantly longer than that recommended for use in cattle without the 24 h safety margin.
There was no significant difference in WP between infected and non-infected udder halves, while there was a weak positive correlation between WP and stage of lactation (R2 = 0.253). There was a moderate positive correlation (R2 = 0.583) between the TRIS test and the presence of dye in milk in udder half samples and between WP in both udder half and composite milk samples (R2 = 0.456). Weak to moderate positive correlations were present between milk yield and the WP in both udder half (R2 = 0.414) and composite (R2 = 0.262) milk samples. Significant differences (P < 0.001) were also observed between the milk yield of udder halves with and without palpable udder damage and between samples that tested TRIS positive and negative on both composite (P = 0.008) and udder half samples (P < 0.001). There was no significant difference between the milk yield of samples with or without dye. There was a significant difference in milk yield between infected and non-infected udder halves (P = 0.054) and a weak negative correlation between milk yield and stage of lactation (R2 = -0.379).

Keywords: Antibiotic withdrawal periods, goat milk, intramammary treatment



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BANGEN, M., SKJERVE, E., GRAVE, K. & SOLI, N.E. 1992. Prescribing of drugs for food producing animals in Norway. Information about withdrawal times. Journal of Veterinary Pharmacology and Therapeutics, 15:180-187.         [ Links ]

DEBACKERE, M. 1995. Pharmacokinetics and pharmacodynamics of antimicrobials in relation to their residues in milk. Proceedings of a Symposium on Residues of Antimicrobial Drugs and other Inhibitors in Milk, Kiel, Germany, 1995: 41.         [ Links ]

DEVENDRA, C. & BURNS, M. 1983. Goat production in the tropics. Slough: Commonwealth Agricultural Bureaux.         [ Links ]

DONKIN, E.F. 1997. Productivity and diseases of Saanen, Indigenous and Crossbred goats on zero grazing. Ph.D. thesis, Medical University of Southern Africa.         [ Links ]

GIESECKE, W.H. & VAN DEN HEEVER, L.W. 1974. A guide to the testing of stock remedies (Act 36/1947) for the treatment and control of septic mastitis of cows (Mastitis Remedies). Department of Agricultural Technical Services, RSA (Technical Communication, no. 123).         [ Links ]

GIESECKE, W.H., DU PREEZ, J.H. & PETZER, I.M. 1994. Practical mastitis control in dairy herds. Durban: Butterworths.         [ Links ]

HONKANEN-BUZALSKI, T. & REYBROECK, W. 1997. Residues and contaminants in milk and milk products: Antimicrobials (International Dairy Federation, Special Issue 9701).         [ Links ]

JAUBERT, G. & KALANTZOPOULOS, G. 1996. Quality of goat milk for cheese and other products. Proceedings of the 6th International Dairy Conference on Goats, Beijing, China, 1996: 274-281.         [ Links ]

KARZIS, J. 2005. Intramammary antibiotics in dairy goats: Withdrawal periods and tissue tolerance. M.Sc. thesis, University of Pretoria.         [ Links ]

LE ROUX, L. 2004. Antibiotika: Antibiotiese klassifikasie-kliniese gebruik van antimikrobiale middels (3), Livestock Health and Production Review, 6:5-9.         [ Links ]

LOW, A. 1986. Agricultural development in Southern Africa: Farm household economics and the food crisis. London: James Currey.         [ Links ]

SANDHOLM, M. 1995. The bovine udder and mastitis. Isolation and identification of pathogens from milk, edited by M. Sandholm, T. Honkanen-Buzalski, L. Kaartinen & S. Pyorala. Jy-väskylä: Gummerus Kirjapaino Oy.         [ Links ]

SMITH, M.C. & SHERMAN, D.M. 1994. Goat medicine. Baltimore: Lippincott, Williams & Wilkins.         [ Links ]

ZENG, S.S., ESCOBAR, E.N. & BROWN-CROWDER, I. 1996. Evaluation of screening tests for detection of antibiotic residues in goat milk. Small Ruminant Research, 21:155-160.         [ Links ]



Accepted for publication 10 June 2008-Editor



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