versão On-line ISSN 0375-1562
versão impressa ISSN 0011-8516
S. Afr. dent. j. vol.70 no.2 Johannesburg Mar. 2015
CEE NoffkeI; EJ RaubenheimerII; NJ ChabikuliIII
IMSc. Head: Radiology, Oral Health Sciences, Sefako Makgatho Health Sciences University, South Africa
IIDSc. Head: Pathology, Oral Health Sciences, Sefako Makgatho Health Sciences University, South Africa
IIIMDS. Senior Stomatologist, Unit Radiology, Oral Health Sciences, Sefako Makgatho Health Sciences University, South Africa
Radiopacities in soft tissue in the maxillofacial and oral region frequently manifest on panoramic radiographs in various locations and in several sizes and shapes. Accurate diagnosis is important as the finding may indicate serious disease states. This manuscript provides guidelines for the interpretation of soft tissue radiopacities seen on dental radiographs and recommends additional radiological views required to locate and diagnose the calcifications.
Soft tissue radiopacities include calcification, ossification or foreign objects. The latter are excluded from this manuscript. Calcification is the deposition of calcium salts in tissue. The pathogenesis is based on either dystrophic or metastatic mechanisms. Dystrophic calcification, which comprises the majority of soft tissue calcifications in the head and neck region, is the result of soft tissue damage with tissue degeneration and necrosis which attracts the precipitation of calcium salts. The blood calcium concentration in these patients is normal. Appropriate examples are calcification of a focus of necrosis of tuberculosis, necrotic tumour tissue or of atheromatous plaque.
Metastatic calcification on the other hand results from the deposition of calcium salts in normal tissue in the presence of hypercalcemia secondary to metabolic causes such as hyperparathyroidism and skeletal deposits of malignant disease. Metastatic calcifications are therefore generally spread more widely throughout the body than dystrophic calcifications which tend to be more localized. The radiology literature is ambiguous in distinguishing between soft tissue calcification and ossification as the distinction can often only be made histologically. Soft tissue ossification is the formation of mature bone with or without bone marrow in an extra-skeletal site. Appropriate examples are elongation of the styloid process through ossification of the attached ligaments and bone formation in synovial chondromatosis.
Idiopathic calcification involves normal serum calcium concentration and healthy tissue, and can as such not be classified as either dystrophic or metastatic. Examples of this are tumorous calcinosis which presents with calcifications around joints and calcinosis cutis, which manifests in the cutaneous or subcutaneous tissue overlying the jaw bones. The latter two conditions are rare and will not be discussed further.
Dental practitioners are required to identify, diagnose, treat or refer for treatment all pathology identified on a radiograph. This paper is aimed at providing practitioners with insight into the differential diagnosis of soft tissue radiopacities seen on dental radiographs. In order to achieve this, a thorough knowledge of the anatomic structures in the head and neck area is important. Accurate interpretation relies on correct positioning of the head during radiographic examinations as this may influence the location and visibility of soft tissue radiopacities on the radiograph. Most calcifications require no further management, but there are several which, if not identified and managed appropriately, could have serious health consequences.
PARAMETERS FACILITATING ACCURATE INTERPRETATION
When radiopacities present as an incidental finding in a soft tissue site, it is of pivotal importance to perform a thorough clinical examination which includes history taking and palpation of the respective site. The anatomical position, number of radiopacities, shape- and size of the calcifications and their internal structure provide important guidelines for their accurate interpretation (Table 1).
Although most radiopacities are asymptomatic, symptoms may be helpful in establishing a diagnosis. The stylohyoid process arises from the inferior surface of the temporal bone and extends infero-mesially towards the pharyngeal wall. Two ligaments (stylohyoid and stylomandibular) and three muscles (stylohyoid, stylopharyngeus and sty-loglossus) originate from this process and together they are sometimes called the "stylohyoid chain". Ossification of one or more of the components of the chain begins normally at the sty-loid process and can create the radiographic image of an elongated styloid process. The stylohyoid ligament is attached at the lesser horn of the hyoid bone and therefore stabilizes it. Patients with an ossified stylo hyoid ligament may manifest with headaches, pain with swallowing, yawning and with moving the head laterally, referred tempo-romandibular joint (TMJ) pain or recurrent throat pain due to impingement of the elongated process on adjacent structures.1,2 A symptomatic ossified sty-lohyoid ligament is referred to as Eagle syndrome and panoramic radiography showing a length of 3cm or more is sufficient to confirm the diagnosis (Figure 1).
A productive cough or history of tuberculosis may be an indication of tuberculous lymphadenitis with dystrophic calcification of lymph nodes.3-5 Calcified lymph nodes are asymptomatic (unless secondarily infected) and may be seen as an incidental finding on a panoramic radiograph at the anatomic sites where lymph nodes are found (Figure 2).4,5 The patient should be informed of the possible implications and referred for follow-up care to exclude active tuberculosis or other serious underlying diseases which could manifest with such calcifications.
Tinnitus or an affirmative history of a stroke, transient ischemic attacks6 or temporary loss of vision (ocular ischemia) may result from stenosis of the carotid artery due to atheromatous plaque, which is often heavily calcified (calcified carotid plaque or CAC, Figure 3). Calcifications in the walls of other arteries (e.g. facial artery) are site-specific and knowledge of the vascular anatomy is required for correct interpretation. In asymptomatic patients early recognition and appropriate referral of patients with CAC reduces morbidity and mortality by preventing vascular obstruction, which has the potential to result in cerebrovascular incidents, coronary heart disease and loss of vision.6-11 CAC and calcified cervical lymph nodes present with overlapping features and may be difficult to differentiate.
Another cause for dystrophic calcification in lymph nodes is necrotic metastatic malignant deposit which frequently occurs post chemo- or radio therapy. Swelling and pain upon salivation mainly during meals may prompt a clinical diagnosis of chronic sub-mandibular sialadenitis due to the presence of one or more calcified submandibular sialoliths which obstruct the flow of saliva (Figures 4 and 5).
Tonsilloliths develop due to chronic inflammation of the tonsils. If large, they protrude from the tonsillar crypts and manifest clinically as yellow or white stones. Symptoms such as tonsillar swelling, pain, difficulty in swallowing, the sensation of a foreign object in the throat12 and halitosis may be present. A clinical diagnosis supported by multiple small radiopacities superimposed on the mid-ramus and angle of the mandible on a panoramic view is sufficient for the diagnosis of tonsilloliths (Figure 6). If uncertain, CBCT examination can be performed which will confirm the location in the tonsillar bed.
Myositis Ossificans is dystrophic calcification within a muscle and is induced by trauma and haemorrhage and can be localized when affecting only one muscle or generalized, affecting several muscles. The muscles of mastication can be involved and the condition is therefore seen in their anatomical locations (Figure 7).
Synovial osteochondromatosis13 and tumoral calcinosis14,15 are rare disorders which more commonly affect major joints than the TMJ. Synovial osteochondromatosis is usually characterized by unilateral osteo-cartilagenous nodules in the synovium of the joint (Figure 8) and may be associated with pain and swelling, while tumoral calcinosis presents with painless nodular swelling in the soft tissue surrounding the TMJ. Some panoramic machines have special TMJ programs which facilitate the identification of radiodense deposits in and around the joint.
Calcifications of the laryngeal cartilage occur at an advanced age and present in the superior horn of the thyroid cartilage and the triticeous cartilage (Figure 9).16,17 Both structures occur bilaterally in the upper neck and may be located in the vicinity of the carotid bifurcation. These must be distinguished from CAC which may occur in the same anatomical site by employing additional radiological examinations. The superior 2 to 3mm of the superior horn of the thyroid cartilage, when calcified, is seen on a panoramic radiograph as a cord-like soft tissue calcification with the rounded top mesial to C4 (Figure 9).16 The triticeous cartilages are bilateral, well-defined single ovoid faint radiopaque structures located in the lateral thyrohyoid ligament at the level of C3 and C4 between the superior horn of the thyroid cartilage and the greater horn of the hyoid bone (Figure 9).9,16,17 The distal portion of the greater horn of the hyoid bone may be misinterpreted as CAC as it is located in the region of the carotid bifurcation (Figure 9). Phleboliths are rare and associated with calcified thrombi in veins, hemangiomas or venous malformations of the oro-facial structures.9,18 They are most frequently localized in the cheek area, rarely in the neck and occur in both children and adults. Phleboliths are randomly distributed and present as regular and spherical radiopacities with mixed density, referred to as laminated18 or onion-like.9 When seen on dental radiographs, they might be confused with sialoliths, tonsilloliths or intrabony lesions. Their association with a vascular anomaly or hemangioma in hard- or soft tissue is, however pathognomonic.
Calcified fibro-epithelial polyp and calcified gingival tumours e.g. peripheral ossifying fibroma are rare and may appear as regular or irregular oval radiopacities superimposed over the occlusal third of teeth.
ANCILLARY RADIOGRAPHIC TECHNIQUES
A combination of clinical-and dental radiographic examinations may confirm most soft tissue radiopacities and additional radiographic techniques can be employed to locate them. On panoramic radiographs salivary stones (sialoliths) in the duct of the submandibular salivary gland may be superimposed on the body of the mandible and mimic intra-bony radiopacities. It is beyond the scope of this manuscript to discuss the conditions manifesting as radiopacities within bone, however standard occlusal- or lateral oblique radiographs, the submentovertex projection, sialography or CBCT are pivotal in confirming the location outside bone and in the soft tissue of the floor of the mouth (Figure 5). Three-dimensional CBCT is a cost-ineffective alternative to these techniques. Parotid duct calculus may be differentiated from a bony lesion in the maxilla by placing a periapical film in the buccal vestibule opposite the duct and irradiating the area while the patient blows up the cheek. The exposure dose should be less than with hard tissue to prevent "burning out" of the less calcified salivary stones.
Panoramic radiography is not considered suitable for population-level screening for carotid stenosis.6,19 The reason is that only calcified carotid plaque is seen on panoramic radiographs and the presence of a calcification is not always indicative of non-calcified atheromatous stenosis.6 Panoramic radiographs are, however frequently prescribed during dental care, are non-invasive, cost effective and of good reliability when calcified carotid plaque is present.20-26 It has been reported that carotid stenosis of 50% and more is almost always calcified and detectable on panoramic radiographs.6 The diagnosis of CAC should however be confirmed by Duplex Doppler ultrasound11,27-29 or CBCT.9 Angiography,6 frontal radiography of the neck,6 cervical spine radiography, magnetic resonance imaging and conventional computed tomography have also been used for the detection or confirmation of calcified atheromatous plaque.24 Synovial chondromatosis, tumoral calcinosis, antroliths and rhinoliths can be confirmed by examinations like CBCT or conventional computed tomography. Although antroliths (Figure 10) and rhinoliths are easily recognized on panoramic radiographs, extraoral radiographs such as the postero-anterior skull- and the Waters projection are often helpful in confirming a suspicion of an antrolith or rhinolith respectively.
In general, incidental findings of soft tissue calcification in the neck may be life-saving especially in the case of carotid artery calcifications and tuberculosis. The dentist is advised to refer a patient with undiagnosed and possible life-threatening soft tissue calcifications in the neck for further examination.19
Declaration: No conflict of interest was declared.
CAC: calcified carotid plaque
CBCT: cone beam computed tomography
CTC: calcified triticeous cartilage
GHH: greater horn of hyoid bone
SHTC: superior horn of thyroid cartilage
1. Raina D, Gothi R, Rajan S. Eagle syndrome. Indian Radiol Imaging 2009; 19:107-8. [ Links ]
2. Baig S, Patil N, Considine N. An unusual cause of recurrent throat pain - calcified stylohyoid ligament. Journal of the College of Physicians and Surgeons Pakistan 2012; 22(4): 258-60. [ Links ]
3. Tortorich J, Woods M, Shintaku W, Anderson KM. Diagnostic considerations of calcified lymph nodes. Journal of the Tennessee Dental Association 2014 ;93(2): 8-10. [ Links ]
4. Aydin U. Tuberculous lymph node calcification detected on routine panoramic radiography: a case report. Dentomaxillofac Radiol 2003; 32(4):252-4. [ Links ]
5. Kara MI, Yeler E, Yeler H, Ay S. Panoramic radiographic appearance of massive calcification of tuberculous lymph nodes. The Journal of Contemporary Dental Practice 2008; 9(6): 1-6. [ Links ]
6. Garoff M, Johansson E, Ahlqvist J, Jaeghagen EL, Arnerlov C, Wester P. Detection of calcifications in panoramic radiographs in patients with carotid stenosis. Oral Surg Oral Med Oral Pathol Oral Radiol 2014; 117(3): 385-91. [ Links ]
7. Cohen SN, Friedlander AH, Jolly DA, Date L. Carotid calcification on panoramic radiographs: An important marker for vascular risk. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94(4):510-14. [ Links ]
8. Tanaka T, Morimoto y, Ansai,T et al. Can the presence of carotid artery calcification on panoramic radiographs predict the risk of vascular diseases among 80-year-olds? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101(6): 777 83. [ Links ]
9. Scarfe WC, Farman AG. Soft tissue calcifications in the neck: Maxillofacial CBCT presentation and significance. AADMRT Currents 2010; 2(2):3-15. [ Links ]
10. Uthman AT, Al-Saffar A: Prevalence in digital panoramic radiographs of carotid area calcification among Iraqi individuals with stroke-related disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105(4): 68-73. [ Links ]
11. Noffke CEE, Farman AG, van der Linde A, Nel S. Responsible use of cone beam computed tomography: minimising medico-legal risks. SADJ 2013; 68(6): 256-9. [ Links ]
12. Ahmad M. Discrete radiopacity in two adult males. North-west Dentistry 2007; 86 (1):34-5. [ Links ]
13. Lim SW, Jeon SJ, Choi SS, Choi KH. Synovial chondromatosis in the temporomandibular joint: a case with typical imaging features and pathological findings. Br J Radiol 2011; 84(1007):e213-6. doi: 10.1259/bjr/69067316. [ Links ]
14. Ma J, Roland B, Wang S. Tumoral calcinosis in neck region: case report; ASNR Annual Meeting Abstract 2003. [ Links ]
15. Sledz K, Ortiz O, Wax M, Bouquot J. Tumoral calcinosis of the temporomandibular joint: CT and MR findings. Am J Neuroradiol 1995; 16(4):782-5. [ Links ]
16. Carter LC. Discrimination between calcified triticeous cartilage and calcified carotid atheroma on panoramic radiography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000; 90(1): 108-10. [ Links ]
17. Ahmad M, Madden R, Perez L. Triticeous cartilage: prevalence on panoramic radiographs and diagnostic criteria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 99(2): 225-30. [ Links ]
18. Eivazi B, Fasunla AJ, Guldner C, Masberg P, Werner JA, Teymoortash A. Phleboliths from venous malformations of the head and neck. Phlebology 2012. Doi: 10.1258/phleb.2011.01.011029. [ Links ]
19. Bayer S, Helfgen EH, Bos C, Kraus D, Enkling N, Mues S. Prevalence of findings compatible with carotid artery calcifications on dental panoramic radiographs. Clin Oral Invest 2011; 15(4): 563-9. [ Links ]
20. Friedlander AH, Manesh F, Wasterlain CG: Prevalence of detectable carotid artery calcifications on panoramic radiographs of recent stroke victims. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1994: 77(6): 669-73. [ Links ]
21. Ohba T, Takata Y, Ansai T, Morimoto Y, Tanaka T, Kito S, Awano S, Akifusa S, Takehara T. Evaluation of calcified carotid arteryatheromas detected by panoramic radiograph among 80-year-olds. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 96(5):647-50. [ Links ]
22. Pornprasertsuk-Damrongsri S, Thanakun S. Carotid artery calcification detected on panoramic radiographs in a group of Thai population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101(1): 110-5. [ Links ]
23. Kumagai M, Yamagishi T, Fukui N, Chiba M. Carotid artery calcification seen on panoramic dental radiographs in the Asian population in Japan. Dentomaxillofac Radiol 2007; 36(2): 92-6. [ Links ]
24. Alzoman HA, Al-Sadhan RI, Al-Lahem ZH, Al-Sakaker AN, Al-Fawaz YF. Prevalence of carotid calcification detected on panoramic radiographs in a Saudi population from a training institute in Central Saudi Arabia. Saudi Med J 2012; 33(2): 177-81. [ Links ]
25. Sisman Y, Ertas ET, Gokce C, Menku A, Ulker M, Akgunlu F. The prevalence of carotid artery calcification on the panoamic radiographs in Cappadocia region population. Eur J Dent 2007; 1(3): 132-8. [ Links ]
26. Yoon SJ, Yoon W, Kim OS, Lee JS, Kang BC. Diagnostic accuracy of panoramic radiography in the detection of calcified carotid artery. Dentomaxillofac Radiol 2008; 37(2):104-8. [ Links ]
27. Wyman RA, Fraizer MC, Keevil JG et al. Utrasound-detected carotid plaque as a screening tool for advanced subclinicalatherosclerosis. Am Heart J 2005; 150(5): 1081-5. [ Links ]
28. Romano-Sousa CM, Krejci L, Marchioro F et al. Diagnostic agreement between panoramic radiographs and colour Doppler images of carotid atheroma. J Appl Oral Sci 17(1):1-6. [ Links ]
29. Johansson EP, Ahlqvist J, Garoff M, Karp K, Aghagen EL,Wester P. Ultrasound screening for asymptomatic carotid stenosis in subjects with calcifications in the area of the carotid arteries on panoramic radiographs: a cross-sectional study. BMC Cardiovasc Disord 2011; 11: 44. http//dx.doi.org/10.1186/1471-2261-11-44. [ Links ]
Head: Unit Radiology
Oral Health Sciences, Box D17
Sefako Makgatho Health Sciences University, 0204.
Tel: (W): 012 521 4902/3, (H): 012 460 4408, Cell: 082 889 9406 Fax: 012 5215901,