Resumo

ISMAIL, A  e  WADEE, R. A comparison of malignant histopathological diagnoses on uterine curettings and hysterectomy specimens. SAJOG [online]. 2022, vol.28, n.1, pp.10-15. ISSN 2305-8862.  http://dx.doi.org/10.7196/SAJOG.2022.v28i1.2078.

BACKGROUND: Endometrial carcinoma (EC) is a common gynaecological malignancy in postmenopausal females. Diagnosis is made on endometrial biopsy, where histological subtype and tumour grade are used to predict disease progression and to plan surgical management OBJECTIVES: To determine the accuracy of preoperative biopsies compared with the final diagnosis on hysterectomy specimens Methods. This was a retrospective, cross-sectional study in which 126 biopsies and corresponding hysterectomy specimens, collected over a 3-year period, were reviewed. Patient demographics and histological features were recorded and statistically analysed. RESULTS: The most prevalent tumours were endometrioid endometrial carcinoma (EEC) (48.5%), serous carcinomas (25.4%) and carcinosarcomas (16.7%). The majority (66.7%) of tumours were high-grade tumours on biopsy and hysterectomy specimens (58.7% EECs had a poor sensitivity level (65.1%) compared with other subtypes but had a high specificity rate (90%). There was moderate agreement between biopsy and excision specimen diagnoses. High-grade tumours had a high sensitivity level (94.3%). CONCLUSIONS: Our study showed moderate agreement between histopathological diagnoses on biopsy and excision specimens. There was

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