Abstract

OKOYE, Jude O. et al. Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression. Afr. J. Lab. Med. [online]. 2021, vol.10, n.1, pp.1-10. ISSN 2225-2010.  http://dx.doi.org/10.4102/ajlm.v10i1.975.

This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182.

Keywords : Epstein-Barr virus; human papilloma virus; herpes simplex virus 2; epithelial-mesenchymal transition; microRNAs.

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