SciELO - Scientific Electronic Library Online

 
vol.22 número1Indicator-focussed technical assistance in South Africa's HIV programme: A stepped-wedge evaluation índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Southern African Journal of HIV Medicine

versão On-line ISSN 2078-6751
versão impressa ISSN 1608-9693

Resumo

DECLOEDT, Eric H. et al. Pharmacogenetics of tenofovir and emtricitabine penetration into cerebrospinal fluid. South. Afr. j. HIV med. (Online) [online]. 2021, vol.22, n.1, pp.1-24. ISSN 2078-6751.  http://dx.doi.org/10.4102/sajhivmed.v22i1.1206.

BACKGROUND: Blood-cerebrospinal fluid (CSF) barrier transporters affect the influx and efflux of drugs. The antiretrovirals tenofovir and emtricitabine may be substrates of blood-brain barrier (BBB) and blood-CSF barrier transporters, but data are limited regarding the pharmacogenetics and pharmacokinetics of their central nervous system (CNS) penetrationOBJECTIVES: We investigated genetic polymorphisms associated with CSF disposition of tenofovir and emtricitabineMETHOD: We collected paired plasma and CSF samples from 47 HIV-positive black South African adults who were virologically suppressed on efavirenz, tenofovir and emtricitabine. We considered 1846 single-nucleotide polymorphisms from seven relevant transporter genes (ABCC5, ABCG2, ABCB1, SLCO2B1, SCLO1A2, SLCO1B1 and ABCC4) and 782 met a linkage disequilibrium (LD)-pruning thresholdRESULTS: The geometric mean (95% confidence interval [CI]) values for tenofovir and emtricitabine CSF-to-plasma concentration ratios were 0.023 (0.021-0.026) and 0.528 (0.460-0.605), respectively. In linear regression models, the lowest p-value for association with the tenofovir CSF-to-plasma ratio was ABCB1 rs1989830 (p = 1.2 × 103) and for emtricitabine, it was ABCC5 rs11921035 (p = 1.4 × 103). None withstood correction for multiple testingCONCLUSION: No genetic polymorphisms were associated with plasma, CSF concentrations or CSF-to-plasma ratios for either tenofovir or emtricitabine

Palavras-chave : pharmacokinetics; pharmacogenetics; tenofovir; emtricitabine; cerebrospinal fluid.

        · texto em Inglês     · Inglês ( pdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons