Resumo

HARIYANTO, Timotius I.; ROSALIND, Jane; CHRISTIAN, Kevin  e  KURNIAWAN, Andree. Human immunodeficiency virus and mortality from coronavirus disease 2019: A systematic review and meta-analysis. South. Afr. j. HIV med. (Online) [online]. 2021, vol.22, n.1, pp.1-7. ISSN 2078-6751.  http://dx.doi.org/10.4102/sajhivmed.v22i1.1220.

BACKGROUND: Persons living with human immunodeficiency virus (PLWH) constitute a vulnerable population in view of their impaired immune status. At this time, the full interaction between HIV and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been incompletely described. OBJECTIVE: The purpose of this study was to explore the impact of HIV and SARS-CoV-2 co-infection on mortality. METHOD: We systematically searched PubMed and the Europe PMC databases up to 19 January 2021, using specific keywords related to our aims. All published articles on coronavirus disease 2019 (COVID-19) and HIV were retrieved. The quality of the studies was evaluated using the Newcastle-Ottawa Scale for observational studies. Statistical analysis was performed with Review Manager version 5.4 and Comprehensive Meta-Analysis version 3 software. RESULTS: A total of 28 studies including 18 255 040 COVID-19 patients were assessed in this meta-analysis. Overall, HIV was associated with a higher mortality from COVID-19 on random-effects modelling {odds ratio [OR] = 1.19 [95% confidence interval (CI) = 1.01-1.39], p = 0.03; I² = 72%}. Meta-regression confirmed that this association was not influenced by age (p = 0.208), CD4 cell count (p = 0.353) or the presence of antiretroviral therapy (ART) (p = 0.647). Further subgroup analysis indicated that the association was only statistically significant in studies from Africa (OR = 1.13, p = 0.004) and the United States (OR = 1.30, p = 0.006. CONCLUSION: Whilst all persons ought to receive a SARS-CoV-2 vaccine, PLWH should be prioritised to minimise the risk of death because of COVID-19. The presence of HIV should be regarded as an important risk factor for future risk stratification of COVID-19.

Palavras-chave : coronavirus disease 2019; COVID-19; SARS-CoV-2; HIV; AIDS.

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