Abstract

ESSA, Ridwaan; MAHARAJ, Shivesh; HARI, Kapila  and  MOTAKEF, Shahpar. Tonsil histopathology in HIV-infected versus HIV-uninfected adults. South. Afr. j. HIV med. (Online) [online]. 2019, vol.20, n.1, pp.1-5. ISSN 2078-6751.  http://dx.doi.org/10.4102/sajhivmed.v20i1.936.

BACKGROUND: The relationship between HIV and tonsil malignancy has not been fully investigated and established. Both of these diseases prominently feature in the Otorhinolaryngology clinics. OBJECTIVE: There is minimal data available on the histopathology of tonsillectomy specimens in the HIV-infected population. This retrospective review compared tonsil histopathology between HIV-infected and HIV-uninfected patients. METHODS: Of the 319 adult patients undergoing tonsillectomy (01 July 2005 to 30 June 2015), HIV results were available for 160. The histological findings were compared in the HIV-infected and HIV-uninfected subgroups. The effects of age, HIV status and CD4 count on the risk of malignancy were determined. RESULTS: There were 86 patients who were HIV-infected and 74 were uninfected. Reactive lymphoid hyperplasia was the most common diagnosis in both groups (77%). Malignancies were diagnosed in eight HIV-infected and six HIV-uninfected patients, an insignificant difference. CONCLUSION: The majority of patients undergoing tonsillectomy had benign conditions. HIV status does not appear to be a specific risk factor for tonsil malignancies, but advanced age may be

Keywords : HIV; Malignancy; Tonsil; Tonsillectomy; HIV-infected patients; HIV-uninfected patients.

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