Sensitivity and specificity of malaria rapid diagnostic test (mRDT CareStatTM) compared with microscopy amongst under five children attending a primary care clinic in southern Nigeria

Ogunfowokan, Oluwagbenga; Ogunfowokan, Bamidele A.; Nwajei, Anthony I.

doi:10.4102/phcfm.v12i1.2212

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African Journal of Primary Health Care & Family Medicine

versão On-line ISSN 2071-2936
versão impressa ISSN 2071-2928

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OGUNFOWOKAN, Oluwagbenga; OGUNFOWOKAN, Bamidele A. e NWAJEI, Anthony I.. Sensitivity and specificity of malaria rapid diagnostic test (mRDT CareStat^TM) compared with microscopy amongst under five children attending a primary care clinic in southern Nigeria. Afr. j. prim. health care fam. med. (Online) [online]. 2020, vol.12, n.1, pp.1-8. ISSN 2071-2936. http://dx.doi.org/10.4102/phcfm.v12i1.2212.

BACKGROUND: Malaria diagnosis using microscopy is currently the gold standard. However, malaria rapid diagnostic tests (mRDTs) were developed to simplify the diagnosis in regions without access to functional microscopy. AIM: The objective of this study was to compare the diagnostic accuracy of mRDT CareStat^TM with microscopy. SETTING: This study was conducted in the paediatric primary care clinic of the Federal Medical Centre, Asaba, Nigeria. METHODS: A cross-sectional study for diagnostic accuracy was conducted from May 2016 to October 2016. Ninety-eight participants were involved to obtain a precision of 5%, sensitivity of mRDT CareStat^TM of 95% from published work and 95% level of confidence after adjusting for 20% non-response rate or missing data. Consecutive participants were tested using both microscopy and mRDT. The results were analysed using EPI Info Version 7. RESULTS: A total of 98 children aged 3-59 months were enrolled. Malaria prevalence was found to be 53% (95% confidence interval [CI] = 46% - 60%), whilst sensitivity and specificity were 29% (95% CI = 20% - 38%) and 89% (95% CI = 83% - 95%), respectively. The positive and negative predictive values were 75% (95% CI = 66.4% - 83.6%) and 53% (95% CI = 46% - 60%), respectively. CONCLUSION: Agreement between malaria parasitaemia using microscopy and mRDT positivity increased with increase in the parasite density. The mRDT might be negative when malaria parasite density using microscopy is low.

Palavras-chave : family medicine; primary care; education; mRDT; parasite density; sensitivity; specificity.

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