SA Orthopaedic Journal
On-line version ISSN 2309-8309
RAUBENHEIMER, EJ and HENDRIK, HD. Cell signalling and bone remodelling: The skeleton as an endocrine relay organ - Part 1. SA orthop. j. [online]. 2015, vol.14, n.4, pp. 16-21. ISSN 2309-8309. http://dx.doi.org/10.17159/2309-8309/2015/v14n4a1.
As knowledge on the signalling pathways involved in bone remodelling unfolds, maintenance of skeletal health and the management of skeletal diseases will increasingly focus on the manipulation of the autocrine, paracrine and endocrine mechanisms involved in the process. This overview is aimed at providing practitioners with an update on recent advances on cell signalling in bone remodelling and highlights the role of the skeleton in systemic metabolism.
Keywords : bone metabolism; cell signalling; skeletal remodelling.