SA Orthopaedic Journal
On-line version ISSN 2309-8309
Print version ISSN 1681-150X
ALLY, Mahmood MTM. Biomarkers in rheumatoid arthritis - the old and new. SA orthop. j. [online]. 2013, vol.12, n.4, pp.19-22. ISSN 2309-8309.
Rheumatoid arthritis (RA) is the prototype autoimmune disease but related mechanisms are involved in numerous other physiological and pathological conditions such as ageing, osteoporosis, chronic osteomyelitis and fracture healing. This article is a review of cellular and molecular components of the immune-inflammatory response in RA with a focus on candidate novel biomarkers that may take us one step closer to the modern quest for personalised medicine.
Keywords : rheumatoid arthritis; mediators of inflammation; pathogenesis; biomarkers.