SA Orthopaedic Journal
versão On-line ISSN 2309-8309
versão impressa ISSN 1681-150X
RAUBENHEIMER, EJ. Part I: Metabolic bone disease: Histomorphometry as a diagnostic aid. SA orthop. j. [online]. 2008, vol.7, n.4, pp.19-23. ISSN 2309-8309.
Metabolic diseases affecting bone are generally diagnosed late when patients present clinically with end stage skeletal debilitation. This is the result of their subclinical progression and the lack of unequivocal biochemical-or radiological techniques to identify bone changes at an early stage. This manuscript presents histomorphometry as a quantifiable method for the accurate assessment of metabolic bone disease at cellular level.