Journal of the South African Veterinary Association
On-line version ISSN 2224-9435
Print version ISSN 1019-9128
LE ROUX-PULLEN, Lérica and VAN DER ZWAN, Henriëtte. Canine multi-drug resistance-1 mutation prevalence: A South African perspective. J. S. Afr. Vet. Assoc. [online]. 2014, vol.85, n.1, pp.01-03. ISSN 2224-9435. http://dx.doi.org/10.4102/jsava.v85i1.1139.
The multi-drug resistance (mdr-1) gene mutation is a phenomenon well known to current veterinary practitioners. The mutation causes a predisposition for, amongst other phenomena, macrocyclic lactone-induced neurotoxicosis in affected canines, a condition that can be fatal. Various herding dog breeds can be heterozygous or homozygous for the mutation, and prevalence differs only slightly in dog populations between geographical regions. This report provides prevalence data of the canine mdr-1 mutation in 306 South African dogs.