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Journal of the South African Veterinary Association

On-line version ISSN 2224-9435
Print version ISSN 1019-9128

Abstract

OLA, Ajay K; SANDHU, Harpal S; DUMKA, Vinod K  and  RANJAN, Bibhuti. Pharmacokinetics, urinary excretion and plasma protein binding of ofloxacin in water buffalo calves (Bubalus bubalis). J. S. Afr. Vet. Assoc. [online]. 2013, vol.84, n.1, pp.01-05. ISSN 2224-9435.

Pharmacokinetics and urinary excretion of an intravenous dose of 5 mg.kg-1 ofloxacin were investigated in water buffalo calves. Plasma concentrations of ofloxacin were determined by high-performance liquid chromatography. Ofloxacin was rapidly distributed from the central to the peripheral compartment as evidenced by a short distribution half-life (0.09 h ± 0.003 h) and high K12 (4.7 h-1 ± 0.1 h-1), and was detected in plasma for 8 h. The large volume of distribution (2.48 L.kg-1 ± 0.18 L.kg-1) obtained in this study indicated high distribution of ofloxacin in water buffalo calves. The elimination half-life, the area under the plasma drug concentration-time curve and total body clearance were 2.11 h ± 0.13 h, 6.20 mg.mL-1 ± 0.23 mg.mL-1.h and 0.81 mL.kg-1.h-1 ± 0.03 mL.kg-1.h-1, respectively. About 18.7% of administered drug was bound to plasma proteins and approximately 32.5% of the administered dose was recovered in urine within 48 h. The results of the study indicated a favourable pharmacokinetic profile of ofloxacin in water buffalo calves, which suggests that ofloxacin may be effective against urinary pathogens in this species.

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